CORE B: ADMINISTRATIVE CORE The overall goal of the Administrative Core is to provide administrative, fiscal and scientific management of this POl Program Project Grant. Key components of this Core will be to provide overall fiscal and administrative coordination. Additional objectives of this Core include organizing scientific interactions communications, and to coordinate interaction with NINDS.

Public Health Relevance

The multi-investigator components of a Program Project Grant require a central Adminisrative Core to assure standard adherence to NIH fiscal and research policies and to coordinate the communications among the groups.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS069539-04
Application #
8434932
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
4
Fiscal Year
2013
Total Cost
$77,511
Indirect Cost
$34,467
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Scully, Michele A; Eichinger, Katy J; Donlin-Smith, Colleen M et al. (2014) Restrictive lung involvement in facioscapulohumeral muscular dystrophy. Muscle Nerve 50:739-43
Zeng, Weihua; Chen, Yen-Yun; Newkirk, Daniel A et al. (2014) Genetic and epigenetic characteristics of FSHD-associated 4q and 10q D4Z4 that are distinct from non-4q/10q D4Z4 homologs. Hum Mutat 35:998-1010
Statland, Jeffrey; Tawil, Rabi (2014) Facioscapulohumeral muscular dystrophy. Neurol Clin 32:721-8, ix
Block, Gregory J; Narayanan, Divya; Amell, Amanda M et al. (2013) Wnt/*-catenin signaling suppresses DUX4 expression and prevents apoptosis of FSHD muscle cells. Hum Mol Genet 22:4661-72
Krom, Yvonne D; Thijssen, Peter E; Young, Janet M et al. (2013) Intrinsic epigenetic regulation of the D4Z4 macrosatellite repeat in a transgenic mouse model for FSHD. PLoS Genet 9:e1003415
Sacconi, Sabrina; Lemmers, Richard J L F; Balog, Judit et al. (2013) The FSHD2 gene SMCHD1 is a modifier of disease severity in families affected by FSHD1. Am J Hum Genet 93:744-51
Block, Gregory J; Petek, Lisa M; Narayanan, Divya et al. (2012) Asymmetric bidirectional transcription from the FSHD-causing D4Z4 array modulates DUX4 production. PLoS One 7:e35532
Balog, Judit; Miller, Dan; Sanchez-Curtailles, Elena et al. (2012) Epigenetic regulation of the X-chromosomal macrosatellite repeat encoding for the cancer/testis gene CT47. Eur J Hum Genet 20:185-91
Geng, Linda N; Yao, Zizhen; Snider, Lauren et al. (2012) DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy. Dev Cell 22:38-51
Sacconi, Sabrina; Camano, Pilar; de Greef, Jessica C et al. (2012) Patients with a phenotype consistent with facioscapulohumeral muscular dystrophy display genetic and epigenetic heterogeneity. J Med Genet 49:41-6

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