The Administrative Core will be responsible for providing scientific administration and coordination, fiscal oversight and administrative support for this program project, keeping the Program a highly integrative and interactive consortium. The Core will coordinate travel arrangements and teleconference interactions for Program scientific group meetings among investigators at the Brigham and Women's Hospital and New York University School of Medicine. This will include annual program meetings for investigators to share data, plan future studies, and discuss how the Program will be optimally managed to enhance scientific communication and further collaboration. A similar effort will also be implemented for the Scientific Advisory Board. The Core will coordinate the administrative aspect of annual progress reports and renewal of subcontract agreements, and will liaison between the grant offices of each institution and the grant and contract officer at the Brigham and Women's Hospital. Dr. Howard L. Weiner will direct the Core with the support of the administrative coordinator, Ms. Shari Ori. The specific administrative functions of Core A are as follows: 1) Coordination of the scientific multi-tiered core with the four PPG projects;2) Facilitate optimal interactions among all participants of the PPG;3) Oversee educational commitments and opportunities for fellows and students;4) Provide a measure of oversight for PPG through the Scientific Advisory Board;5) Oversee internal quality control of ongoing research;6) Management of day-to-day program activities and contractual agreements;7) Oversee allocation of funds;and 8) Maintain fair, effective communication and cooperation among program investigators including resolution of disputes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
1P01NS076410-01A1
Application #
8470954
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
1
Fiscal Year
2013
Total Cost
$26,413
Indirect Cost
$11,413
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Aschenbrenner, Dominik; Foglierini, Mathilde; Jarrossay, David et al. (2018) An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells. Nat Immunol 19:1126-1136
Meyer Zu Horste, Gerd; Przybylski, Dariusz; Schramm, Markus A et al. (2018) Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1. Immunity 48:556-569.e7
Joller, Nicole; Kuchroo, Vijay K (2017) Tim-3, Lag-3, and TIGIT. Curr Top Microbiol Immunol 410:127-156
Karwacz, Katarzyna; Miraldi, Emily R; Pokrovskii, Maria et al. (2017) Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation. Nat Immunol 18:412-421
Hu, Dan; Notarbartolo, Samuele; Croonenborghs, Tom et al. (2017) Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis. Nat Commun 8:1600
Chihara, Norio; Madi, Asaf; Karwacz, Katarzyna et al. (2016) Differentiation and Characterization of Tr1 Cells. Curr Protoc Immunol 113:3.27.1-3.27.10
Anderson, Ana C; Joller, Nicole; Kuchroo, Vijay K (2016) Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation. Immunity 44:989-1004
Meyer Zu Horste, Gerd; Wu, Chuan; Wang, Chao et al. (2016) RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression. Cell Rep 16:392-404
Mayo, Lior; Cunha, Andre Pires Da; Madi, Asaf et al. (2016) IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation. Brain 139:1939-57
Gaublomme, Jellert T; Yosef, Nir; Lee, Youjin et al. (2015) Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity. Cell 163:1400-12

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