This core will support the analysis of the large amount of genomic data that will be obtained from screens in Projects 2 and 3. These data will come from mulitple organisms and multiple cell types. Our goal is to find the commonalities that point to fundemental molecular mechanisms of firing rate homeostasis. The core will also support the generation of molecular tools to manipulate candidate genes in multiple species and cell types. By centralizing and standardizing the design and projection of reagents, we will increase the thoughput, efficiency and interactiveness of the component projects.

Public Health Relevance

Failure of homeostasis is central to many disease states affecting the nervous system. By uncovering the fundemental componenets of firing rate sensors and their homeostatic regulators we will develop new insights into the pathophysiology and treatment of neurological and psychiatric disorders. PROJECT/PERFORMANCE SrrE(

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
1P01NS079419-01A1
Application #
8609249
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2013-09-28
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$229,856
Indirect Cost
$67,166
Name
Brandeis University
Department
Type
DUNS #
616845814
City
Waltham
State
MA
Country
United States
Zip Code
02454