Abstract

This core will support the analysis of the large amount of genomic data that will be obtained from screens in Projects 2 and 3. These data will come from mulitple organisms and multiple cell types. Our goal is to find the commonalities that point to fundemental molecular mechanisms of firing rate homeostasis. The core will also support the generation of molecular tools to manipulate candidate genes in multiple species and cell types. By centralizing and standardizing the design and projection of reagents, we will increase the thoughput, efficiency and interactiveness of the component projects.

Public Health Relevance

Failure of homeostasis is central to many disease states affecting the nervous system. By uncovering the fundemental componenets of firing rate sensors and their homeostatic regulators we will develop new insights into the pathophysiology and treatment of neurological and psychiatric disorders. PROJECT/PERFORMANCE SrrE(

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
1P01NS079419-01A1
Application #
8609249
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2013-09-28
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$229,856
Indirect Cost
$67,166

  Institution

Name
Brandeis University
Department
Type
DUNS #
616845814
City
Waltham
State
MA
Country
United States
Zip Code
02454

  Publications

Joseph, Annelise; Turrigiano, Gina G (2017) All for One But Not One for All: Excitatory Synaptic Scaling and Intrinsic Excitability Are Coregulated by CaMKIV, Whereas Inhibitory Synaptic Scaling Is Under Independent Control. J Neurosci 37:6778-6785
Abraira, Victoria E; Kuehn, Emily D; Chirila, Anda M et al. (2017) The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell 168:295-310.e19
Choy, Julian M C; Suzuki, Norimitsu; Shima, Yasuyuki et al. (2017) Optogenetic Mapping of Intracortical Circuits Originating from Semilunar Cells in the Piriform Cortex. Cereb Cortex 27:589-601
Cannon, Jonathan; Miller, Paul (2017) Stable Control of Firing Rate Mean and Variance by Dual Homeostatic Mechanisms. J Math Neurosci 7:1
O'Toole, Sean M; Ferrer, Monica M; Mekonnen, Jennifer et al. (2017) Dicer maintains the identity and function of proprioceptive sensory neurons. J Neurophysiol 117:1057-1069
Steinmetz, Celine C; Tatavarty, Vedakumar; Sugino, Ken et al. (2016) Upregulation of ?3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway. Cell Rep 16:2711-2722
Cannon, Jonathan; Miller, Paul (2016) Synaptic and intrinsic homeostasis cooperate to optimize single neuron response properties and tune integrator circuits. J Neurophysiol 116:2004-2022
Takeishi, Asuka; Yu, Yanxun V; Hapiak, Vera M et al. (2016) Receptor-type Guanylyl Cyclases Confer Thermosensory Responses in C. elegans. Neuron 90:235-44
Williams, Alex H; O'Donnell, Cian; Sejnowski, Terrence J et al. (2016) Dendritic trafficking faces physiologically critical speed-precision tradeoffs. Elife 5:
Gjorgjieva, Julijana; Drion, Guillaume; Marder, Eve (2016) Computational implications of biophysical diversity and multiple timescales in neurons and synapses for circuit performance. Curr Opin Neurobiol 37:44-52

Showing the most recent 10 out of 15 publications