This core provides administrative support for the program project in the form of oversight of day to day interactions, data sharing, group meetings, and formulation of an external advisory board. The core PI is Gina Turrigiano, Professor of Biology, Brandeis University.

Public Health Relevance

Failure of homeostasis is central to many disease states affecting the nervous system. By uncovering the fundamental components of firing rate sensors and their homeostatic regulators we will develop new insights into the pathophysiology and treatment of neurological and psychiatric disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS079419-02
Application #
8743096
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Brandeis University
Department
Type
DUNS #
City
Waltham
State
MA
Country
United States
Zip Code
02453
O'Leary, Timothy; Marder, Eve (2016) Temperature-Robust Neural Function from Activity-Dependent Ion Channel Regulation. Curr Biol 26:2935-2941
Gjorgjieva, Julijana; Drion, Guillaume; Marder, Eve (2016) Computational implications of biophysical diversity and multiple timescales in neurons and synapses for circuit performance. Curr Opin Neurobiol 37:44-52
Nelson, Sacha B; Valakh, Vera (2015) Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders. Neuron 87:684-98
Drion, Guillaume; O'Leary, Timothy; Marder, Eve (2015) Ion channel degeneracy enables robust and tunable neuronal firing rates. Proc Natl Acad Sci U S A 112:E5361-70
O'Leary, Timothy; Williams, Alex H; Franci, Alessio et al. (2014) Cell types, network homeostasis, and pathological compensation from a biologically plausible ion channel expression model. Neuron 82:809-21