This core provides administrative support for the program project in the form of oversight of day to day interactions, data sharing, group meetings, and formulation of an external advisory board. The core PI is Gina Turrigiano, Professor of Biology, Brandeis University.

Public Health Relevance

Failure of homeostasis is central to many disease states affecting the nervous system. By uncovering the fundamental components of firing rate sensors and their homeostatic regulators we will develop new insights into the pathophysiology and treatment of neurological and psychiatric disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS079419-02
Application #
8743096
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Brandeis University
Department
Type
DUNS #
City
Waltham
State
MA
Country
United States
Zip Code
02453
Joseph, Annelise; Turrigiano, Gina G (2017) All for One But Not One for All: Excitatory Synaptic Scaling and Intrinsic Excitability Are Coregulated by CaMKIV, Whereas Inhibitory Synaptic Scaling Is Under Independent Control. J Neurosci 37:6778-6785
Abraira, Victoria E; Kuehn, Emily D; Chirila, Anda M et al. (2017) The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell 168:295-310.e19
Choy, Julian M C; Suzuki, Norimitsu; Shima, Yasuyuki et al. (2017) Optogenetic Mapping of Intracortical Circuits Originating from Semilunar Cells in the Piriform Cortex. Cereb Cortex 27:589-601
Cannon, Jonathan; Miller, Paul (2017) Stable Control of Firing Rate Mean and Variance by Dual Homeostatic Mechanisms. J Math Neurosci 7:1
O'Toole, Sean M; Ferrer, Monica M; Mekonnen, Jennifer et al. (2017) Dicer maintains the identity and function of proprioceptive sensory neurons. J Neurophysiol 117:1057-1069
Williams, Alex H; O'Donnell, Cian; Sejnowski, Terrence J et al. (2016) Dendritic trafficking faces physiologically critical speed-precision tradeoffs. Elife 5:
Gjorgjieva, Julijana; Drion, Guillaume; Marder, Eve (2016) Computational implications of biophysical diversity and multiple timescales in neurons and synapses for circuit performance. Curr Opin Neurobiol 37:44-52
Crittenden, Jill R; Tillberg, Paul W; Riad, Michael H et al. (2016) Striosome-dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons. Proc Natl Acad Sci U S A 113:11318-11323
O'Leary, Timothy; Marder, Eve (2016) Temperature-Robust Neural Function from Activity-Dependent Ion Channel Regulation. Curr Biol 26:2935-2941
Steinmetz, Celine C; Tatavarty, Vedakumar; Sugino, Ken et al. (2016) Upregulation of ?3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway. Cell Rep 16:2711-2722

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