The Imaging Core supports the following Specific Aims ofthe three scientific projects ofthe Center for Brain Hemorrhage Research: 1) provide neuroimaging for edema (T2-weighted, T2W1), blood (T2WI and suscepribility weighted imaging, SWI), diffusion tensor imaging for white matter abnormalities, cerebral perfusion using both dynamic susceptibility contrast (DSC) and arterial spin labeling (ASL) approaches including cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT) and time to peak (TTP) indices;2) undertake analysis for the collected imaging data, including anatomical mapping of edema and blood, blood brain barrier (BBB) disruption, white matter changes, cerebral perfusion abnormalities;3) provide a centralized location for Project Pi's and staff to access raw and analyzed datasets;4) develop and implement computational routines as we have for other disease states (i.e. stroke, TBI) to automate and speed analysis throughput, and 5) provide statistical and computational support for imaging data comparisons to behavior, cell biology and vascular outcomes. Our comprehensive approach will provide novel data about common interrelationships between three brain models of hemorrhagic injury, Subarachnoid Hemorrhage (SAH), Intracerebral Hemorrhage (ICH), and Traumatic Brain Injury (TBI). Clinical neuroimaging is increasingly taking a significant role in assessment of SAH, ICH, and TBI. A unifying feature of these neurological disease states is the deposition of extravascular blood which is extremely toxic to the brain and leads to rupture ofthe blood brain barrier (BBB). This cascade of events results in development of edema, often with catastrophic outcomes. Numerous studies have demonstrated that rapid imaging ofthe extent and anatomical location of blood is critical for decision-making relative to potential therapeutic interventions. Thus, the Imaging Core has elected for these Projects to focus on early and late indices of brain injury and function: 1) edema, 2) extravascular blood, 3) cerebral perfusion, and 4) white matter function. The Imaging Core will 1) undertake non-invasive but functional measures of brain physiology using MR imaging, 2) use standard and novel computational analysis to maximize data extraction, and 3) use numerical analysis methods to identify common data from all cores (Behavioral, Imaging, Vascular) that emerge for SAH, ICH, and TBI.

Public Health Relevance

The Imaging Core provides additional strengths that could not be obtained using traditional funding mechanisms and overall strengthens and unifies the overarching Aims ofthe Center for Brain Hemorrhage Research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
1P01NS082184-01A1
Application #
8661428
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
1
Fiscal Year
2014
Total Cost
$204,421
Indirect Cost
$74,238
Name
Loma Linda University
Department
Type
DUNS #
009656273
City
Loma Linda
State
CA
Country
United States
Zip Code
92350
Wang, Yuechun; Sherchan, Prativa; Huang, Lei et al. (2017) Naja sputatrix Venom Preconditioning Attenuates Neuroinflammation in a Rat Model of Surgical Brain Injury via PLA2/5-LOX/LTB4 Cascade Activation. Sci Rep 7:5466
Akyol, Gokce Yilmaz; Manaenko, Anatol; Akyol, Onat et al. (2017) IVIG activates Fc?RIIB-SHIP1-PIP3 Pathway to stabilize mast cells and suppress inflammation after ICH in mice. Sci Rep 7:15583
Kim, Cherine H; McBride, Devin W; Sherchan, Prativa et al. (2017) Crotalus helleri venom preconditioning reduces postoperative cerebral edema and improves neurological outcomes after surgical brain injury. Neurobiol Dis 107:66-72
Ma, Li; Manaenko, Anatol; Ou, Yi-Bo et al. (2017) Bosutinib Attenuates Inflammation via Inhibiting Salt-Inducible Kinases in Experimental Model of Intracerebral Hemorrhage on Mice. Stroke 48:3108-3116
Rolland, William B; Krafft, Paul R; Lekic, Tim et al. (2017) Fingolimod confers neuroprotection through activation of Rac1 after experimental germinal matrix hemorrhage in rat pups. J Neurochem 140:776-786
Yu, Lingyan; Lu, Zhengyang; Burchell, Sherrefa et al. (2017) Adropin preserves the blood-brain barrier through a Notch1/Hes1 pathway after intracerebral hemorrhage in mice. J Neurochem 143:750-760
McBride, Devin W; Zhang, John H (2017) Precision Stroke Animal Models: the Permanent MCAO Model Should Be the Primary Model, Not Transient MCAO. Transl Stroke Res :
Hu, Qin; Manaenko, Anatol; Bian, Hetao et al. (2017) Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+/Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats. Stroke 48:1655-1664
Zhang, John H; Obenaus, Andre; Liebeskind, David S et al. (2017) Recanalization, reperfusion, and recirculation in stroke. J Cereb Blood Flow Metab 37:3818-3823
Obenaus, Andre; Ng, Michelle; Orantes, Amanda M et al. (2017) Traumatic brain injury results in acute rarefication of the vascular network. Sci Rep 7:239

Showing the most recent 10 out of 52 publications