The overall goal ofthe Administrative Core is to provide administrative support to the individual projects and cores by facilitating interactions, information sharing, statistical analysis and data integration between Projects I-III and Cores B-D. The Administrative Core will also be responsible for the scheduling of monthly meetings with all project investigators that include: 1) critiques of recent extramural publications relevant to the goals of all projects; 2) presentations by project investigators, particularly when data sets are being readied for publication; 3) updates on changes in the resources, essential infrastructure, and financial status of the PPG; and 4) training of graduate students and postdoctoral fellows in literature research, identifying research subjects, experimental design, trouble-shooting of experimental issues, presentation of experimental data, paper writing, submission and revisions, as well as grant writing. Graduate students and postdoctoral fellows from all PIs' labs will participate in these training events. The Administrative Core will also organize a regular schedule of invited seminar speakers that address topics of both general and specific interest to each ofthe Projects. This program will be coordinated with the Loma Linda University School of Medicine, which will help support costs associated with this visiting scientist program. The Administrative Core will also organize the external advisory committee composed of prominent extramural scientists (see Introduction) who will visit the Center for Brain Hemorrhage Research on an annual basis to review progress and project status and then issue written assessments and recommendations for continued success. The Administrative Core will contract two statisticians to participate in data processing and analysis. Finally, the Administrative Core will also coordinate the collection and compilation of all details necessary for timely filing of annual progress reports.

Public Health Relevance

The Administrative Core is instrumental in the administrative support and evaluation of the activities of this PPG, including facilitating interactions, information sharing, statistical analysis, and other administrative issues.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS082184-05
Application #
9406357
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
2019-12-31
Budget Start
2018-01-01
Budget End
2018-12-31
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Loma Linda University
Department
Type
DUNS #
009656273
City
Loma Linda
State
CA
Country
United States
Zip Code
92350
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Zhou, Keren; Enkhjargal, Budbazar; Xie, Zhiyi et al. (2018) Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat. Stroke 49:175-183
Xie, Zongyi; Huang, Lei; Enkhjargal, Budbazar et al. (2018) Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPAR?/NF?B signaling pathway after subarachnoid hemorrhage in rats. Brain Behav Immun 69:190-202
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Tong, Lu-Sha; Guo, Zhen-Ni; Ou, Yi-Bo et al. (2018) Cerebral venous collaterals: A new fort for fighting ischemic stroke? Prog Neurobiol 163-164:172-193
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Pearce, W J (2018) A path well travelled may lead to better stroke recovery. Acta Physiol (Oxf) 223:e13061
Lu, Tai; Wang, Zhong; Prativa, Sherchan et al. (2018) Macrophage stimulating protein preserves blood brain barrier integrity after intracerebral hemorrhage through recepteur d'origine nantais dependent GAB1/Src/?-catenin pathway activation in a mouse model. J Neurochem :
Wu, Guangyong; McBride, Devin W; Zhang, John H (2018) Axl activation attenuates neuroinflammation by inhibiting the TLR/TRAF/NF-?B pathway after MCAO in rats. Neurobiol Dis 110:59-67
Xie, Zhiyi; Enkhjargal, Budbazar; Wu, Lingyun et al. (2018) Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats. Neuropharmacology 128:142-151

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