(Core B) The primary goal of the Neuropathology Core (Core B) is to provide high quality human fetal, neonatal and pediatric brain tissues for all the components of the program project. In addition, Core B will also collaborate with researchers and project leaders in this PPG to characterize cell lineages in the developing human brains and develop state-of-the-art molecular markers that will facilitate the discovery and characterizations of neuronal and glial lineages during normal human brain development and in hypoxic ischemic injury conditions. Core B will provide full-time histopathology services that facilitate the progress among the research projects in this PPG as well as coordinate activities with the internal and external advisory committees. In essence, the aim of the Neuropathology Core is to function as a centralized facility where human brain tissues and advances in histopathology techniques can be utilized to provide support and integration of services for all investigators. The core director will work with the project leaders and make decisions regarding the use of core services. As an active member of the PPG, the core director will participate in weekly meetings on Fridays regarding administrative and scientific matters such as research directions, requests for specific human tissues, data analyses, collaborations and presentations of data. The core director, in consultation with Dr. Rowitch, Dr. Alveraz-Buylla and Dr. Kriegstein, will evaluate the specific needs and cost-effectiveness in order to maximize the service of Core B to each research project. The core director will ensure that quality control is provided at the highest level. Additional quality control will be achieved through the use of our internal and external advisory committees.

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
1P01NS083513-01A1
Application #
8742987
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Yuen, Tracy J; Silbereis, John C; Griveau, Amelie et al. (2014) Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis. Cell 158:383-96