The Animal Model Core will be managed from the Department of Pathobiology, but will be active at both the Animal Resource Center (ARC) at CWRU and the Biomedical Resource Center (BRU) in the Lerner Research Institute at the Cleveland Clinic (CC). The functional operation of this core predates the submission of this proposal and, therefore, the proposed Animal Models and Cell Isolation Core (Animal Core) benefits from our experienced personnel and the existing infrastructure at both the BRU and ARC facilities. Dr. Nagy's laboratory has extensive experience with the use of the Lieber-DeCarli ad libitum ethanol exposure model in both rats and mice (1-4). In the past several years, Dr. Nagy's group has collaborated with each of the Pis on the Exploratory Projects to provide plasma, tissue and isolated cell samples from rats and mice after acute and chronic ethanol exposures. We have experience in coordinating the procedures required and have carried out these functions in both the BRU and ARC facilities. Recent abstracts from collaborations between members of the Cleveland Alcohol Center using samples from our pre-existing core are listed below in section E.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Exploratory Grants (P20)
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Special Emphasis Panel (ZAA1-BB)
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Cleveland Clinic Lerner
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Barnes, Mark A; Roychowdhury, Sanjoy; Nagy, Laura E (2014) Innate immunity and cell death in alcoholic liver disease: role of cytochrome P4502E1. Redox Biol 2:929-35
Bakhautdin, Bakytzhan; Das, Dola; Mandal, Palash et al. (2014) Protective role of HO-1 and carbon monoxide in ethanol-induced hepatocyte cell death and liver injury in mice. J Hepatol 61:1029-37
Thapaliya, Samjhana; Runkana, Ashok; McMullen, Megan R et al. (2014) Alcohol-induced autophagy contributes to loss in skeletal muscle mass. Autophagy 10:677-90
Latchoumycandane, Calivarathan; Nagy, Laura E; McIntyre, Thomas M (2014) Chronic ethanol ingestion induces oxidative kidney injury through taurine-inhibitable inflammation. Free Radic Biol Med 69:403-16
Roychowdhury, Sanjoy; Chiang, Dian J; McMullen, Megan R et al. (2014) Moderate, chronic ethanol feeding exacerbates carbon-tetrachloride-induced hepatic fibrosis via hepatocyte-specific hypoxia inducible factor 1? Pharmacol Res Perspect 2:e00061
Cresci, Gail A; Bush, Katelyn; Nagy, Laura E (2014) Tributyrin supplementation protects mice from acute ethanol-induced gut injury. Alcohol Clin Exp Res 38:1489-501
Barnes, Mark A; McMullen, Megan R; Roychowdhury, Sanjoy et al. (2013) Macrophage migration inhibitory factor contributes to ethanol-induced liver injury by mediating cell injury, steatohepatitis, and steatosis. Hepatology 57:1980-91
Dixon, Laura J; Flask, Chris A; Papouchado, Bettina G et al. (2013) Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis. PLoS One 8:e56100
Dixon, Laura J; Barnes, Mark; Tang, Hui et al. (2013) Kupffer cells in the liver. Compr Physiol 3:785-97
Roychowdhury, Sanjoy; McMullen, Megan R; Pisano, Sorana G et al. (2013) Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury. Hepatology 57:1773-83

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