Section 4. Initial Planning StageDrs. Chung and Davidson have already identified an area of common interest and of high importance: thecircadian biology of prostate cancer. Further, we have selected an Internal Advisory Committee made up of 6distinguished cancer faculty, 3 from each partner institution to help select the 2nd and any future collaborativepilot projects that are to be funded via this grant. Consequently, the Planning Stage is virtually complete. Forthis reason we are only requesting 3 years of support, making this section unnecessary for our application. Theonly planning activities proposed are a series of lectures occurring both at MSM and WCI that are intended tohelp foster collaborations beyond those already proposed in this application. We will hold 4 lectures, 2 at MSMwhere Emory faculty involved in cancer research will be invited to speak about their research and meet withtrainees. AUC faculty and students will be invited to the lectures. The other two will be presented by MSMcancer faculty at Emory. We will also host one major lecture per year at MSM on the topic of circadian biologyof cancer. The speaker will be an internationally recognized cancer scientist or physician.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory Grants (P20)
Project #
1P20CA132388-01
Application #
7425621
Study Section
Special Emphasis Panel (ZCA1-SRRB-Y (O1))
Project Start
2007-12-01
Project End
2010-07-31
Budget Start
2007-12-01
Budget End
2008-07-31
Support Year
1
Fiscal Year
2007
Total Cost
$25,651
Indirect Cost
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Li, Guang; Wei, Jie; Kadbi, Mo et al. (2017) Novel Super-Resolution Approach to Time-Resolved Volumetric 4-Dimensional Magnetic Resonance Imaging With High Spatiotemporal Resolution for Multi-Breathing Cycle Motion Assessment. Int J Radiat Oncol Biol Phys 98:454-462
Wang, Ruoxiang; Sun, Xiaojuan; Wang, Christopher Y et al. (2012) Spontaneous cancer-stromal cell fusion as a mechanism of prostate cancer androgen-independent progression. PLoS One 7:e42653
Zhau, Haiyen E; He, Hui; Wang, Christopher Y et al. (2011) Human prostate cancer harbors the stem cell properties of bone marrow mesenchymal stem cells. Clin Cancer Res 17:2159-69
He, Hui; Davidson, Alec J; Wu, Daqing et al. (2010) Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaPE cells. Prostate 70:1119-26
Sun, Xiaojuan; He, Hui; Xie, Zhihui et al. (2010) Matched pairs of human prostate stromal cells display differential tropic effects on LNCaP prostate cancer cells. In Vitro Cell Dev Biol Anim 46:538-46
Thalmann, George N; Rhee, Hong; Sikes, Robert A et al. (2010) Human prostate fibroblasts induce growth and confer castration resistance and metastatic potential in LNCaP Cells. Eur Urol 58:162-71
He, Hui; Xu, Jianchun; Nelson, Peter S et al. (2010) Differential expression of the alpha2 chain of the interleukin-13 receptor in metastatic human prostate cancer ARCaPM cells. Prostate 70:993-1001
He, Hui; Yang, Xiaojian; Davidson, Alec J et al. (2010) Progressive epithelial to mesenchymal transitions in ARCaP E prostate cancer cells during xenograft tumor formation and metastasis. Prostate 70:518-28
Wang, Ruoxiang; He, Hui; Sun, Xiaojuan et al. (2009) Transcription variants of the prostate-specific PrLZ gene and their interaction with 14-3-3 proteins. Biochem Biophys Res Commun 389:455-60
Odero-Marah, Valerie A; Wang, Ruoxiang; Chu, Gina et al. (2008) Receptor activator of NF-kappaB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells. Cell Res 18:858-70