The mission of the Einstein HAND Proteomics Research Center is to evaluate the interactions of drug addiction and its treatment on the development and progression of HIV associated neurocognitive disorders (HAND). The central research themes of the pilot Einstein HAND Proteomics Research Center (EHPRC) will focus on investigating the mechanism by which HIV infection causes HAND, identifying biomarkers for the onset and course of HAND and the potential additive impact of buprenorphine treatment on the development and progression of HAND by utilizing proteomic approaches in humans, animal models and cell culture. The EHPRC will provide the proteomics, bioinformatics, data integration, and statistical support for three synergistic projects. Scientific interactions and project integration will be fostered by a laboratory information management system (LIMS), an EHPRC web site, weekly lab meetings of EHPRC members, and annual presentations at meetings with internal and external advisory committees.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Exploratory Grants (P20)
Project #
5P20DA026149-03
Application #
8234085
Study Section
Special Emphasis Panel (ZDA1)
Project Start
Project End
2012-02-29
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
3
Fiscal Year
2011
Total Cost
$72,344
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Nika, Heinz; Angeletti, Ruth Hogue; Hawke, David H (2016) Phosphopeptide Enrichment by Covalent Chromatography After Solid Phase Derivatization of Protein Digests on Reversed Phase Supports. Methods Mol Biol 1355:31-50
Arias, Franchesca; Arnsten, Julia H; Cunningham, Chinazo O et al. (2016) Neurocognitive, psychiatric, and substance use characteristics in opioid dependent adults. Addict Behav 60:137-43
Carvallo, Loreto; Lopez, Lillie; Che, Fa-Yun et al. (2015) Buprenorphine decreases the CCL2-mediated chemotactic response of monocytes. J Immunol 194:3246-58
Nika, Heinz; Angeletti, Ruth Hogue; Hawke, David H (2014) N-terminal protein characterization by mass spectrometry using combined microscale liquid and solid-phase derivatization. J Biomol Tech 25:77-86
Nika, Heinz; Hawke, David H; Angeletti, Ruth Hogue (2014) N-terminal protein characterization by mass spectrometry after cyanogen bromide cleavage using combined microscale liquid- and solid-phase derivatization. J Biomol Tech 25:19-30
Nika, Heinz; Hawke, David H; Angeletti, Ruth Hogue (2014) C-terminal protein characterization by mass spectrometry: isolation of C-terminal fragments from cyanogen bromide-cleaved protein. J Biomol Tech 25:1-18
Fleitz, Antoine; Nieves, Edward; Madrid-Aliste, Carlos et al. (2013) Enhanced detection of multiply phosphorylated peptides and identification of their sites of modification. Anal Chem 85:8566-76
Berezniuk, Iryna; Lyons, Peter J; Sironi, Juan J et al. (2013) Cytosolic carboxypeptidase 5 removes ?- and ?-linked glutamates from tubulin. J Biol Chem 288:30445-53
Nika, Heinz; Nieves, Edward; Hawke, David H et al. (2013) Phosphopeptide enrichment by covalent chromatography after derivatization of protein digests immobilized on reversed-phase supports. J Biomol Tech 24:154-77
Nika, Heinz; Nieves, Edward; Hawke, David H et al. (2013) C-terminal protein characterization by mass spectrometry using combined micro scale liquid and solid-phase derivatization. J Biomol Tech 24:17-31

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