The Bioinformatics/Biostatistics Core (BBC Core) will set up a Laboratory Information Management System (LIMS) using the open source Sesame software and establish a project data integration web site (e.g.,http://toro.aecom.yu.edu/biodefense/). All primary and processed data will be placed on the web site. Patient data will be kept by MIS at Montefiore Medical Center. A firewall has been established so that patient data cannot be accessed. Only patient and sample codes for proteomics will be provided for the analysts. The Bioinformatics/Biostatistics Core will also provide consulting on advanced study design, sample size justification and statistical analysis of quantitative expression with parameters reflecting the individual projects, and decode the samples to correlate with appropriate parameters, such as ? HIV, ?HAART, ? IPS,? buprenorphine, cytokine expression, neurological symptoms, transmigration rates, etc.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Exploratory Grants (P20)
Project #
5P20DA026149-03
Application #
8234087
Study Section
Special Emphasis Panel (ZDA1)
Project Start
Project End
2012-02-29
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
3
Fiscal Year
2011
Total Cost
$200,343
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Nika, Heinz; Angeletti, Ruth Hogue; Hawke, David H (2016) Phosphopeptide Enrichment by Covalent Chromatography After Solid Phase Derivatization of Protein Digests on Reversed Phase Supports. Methods Mol Biol 1355:31-50
Arias, Franchesca; Arnsten, Julia H; Cunningham, Chinazo O et al. (2016) Neurocognitive, psychiatric, and substance use characteristics in opioid dependent adults. Addict Behav 60:137-43
Carvallo, Loreto; Lopez, Lillie; Che, Fa-Yun et al. (2015) Buprenorphine decreases the CCL2-mediated chemotactic response of monocytes. J Immunol 194:3246-58
Nika, Heinz; Angeletti, Ruth Hogue; Hawke, David H (2014) N-terminal protein characterization by mass spectrometry using combined microscale liquid and solid-phase derivatization. J Biomol Tech 25:77-86
Nika, Heinz; Hawke, David H; Angeletti, Ruth Hogue (2014) N-terminal protein characterization by mass spectrometry after cyanogen bromide cleavage using combined microscale liquid- and solid-phase derivatization. J Biomol Tech 25:19-30
Nika, Heinz; Hawke, David H; Angeletti, Ruth Hogue (2014) C-terminal protein characterization by mass spectrometry: isolation of C-terminal fragments from cyanogen bromide-cleaved protein. J Biomol Tech 25:1-18
Fleitz, Antoine; Nieves, Edward; Madrid-Aliste, Carlos et al. (2013) Enhanced detection of multiply phosphorylated peptides and identification of their sites of modification. Anal Chem 85:8566-76
Berezniuk, Iryna; Lyons, Peter J; Sironi, Juan J et al. (2013) Cytosolic carboxypeptidase 5 removes ?- and ?-linked glutamates from tubulin. J Biol Chem 288:30445-53
Nika, Heinz; Nieves, Edward; Hawke, David H et al. (2013) Phosphopeptide enrichment by covalent chromatography after derivatization of protein digests immobilized on reversed-phase supports. J Biomol Tech 24:154-77
Nika, Heinz; Nieves, Edward; Hawke, David H et al. (2013) C-terminal protein characterization by mass spectrometry using combined micro scale liquid and solid-phase derivatization. J Biomol Tech 24:17-31

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