Project 2: After marijuana, amphetamines are the most widely used illicit drug class woridwide and recent evidence shows that methamphetamine causes about 895 deaths per year in the U.S. and is responsible for an annual economic burden of $23.5 billion. Interoception comprises the sensing of the physiological condition of the body, consciously representing this internal state within the context of ongoing activities, and inifiating mofivated action to homeostatically regulate this state. Previous investigations have shown that individuals with insular lesions reported they had """"""""lost the urge to smoke,"""""""" and our results indicate that attenuated activation in insula was related to an increase propensity to relapse. Although this links interoception to insular functioning abnormalities to drug addiction, the precise role of interoception in drug addiction is unclear. To test the hypothesis that dysregulated insular cortex function in amphetamine dependent (AD) individual results in an insufficient, instable, or non-adaptive adjustment to perturbations of the internal state, we will examine using event-related fMRI the neural processing of: (1) direct interoceptive stimulation during positively valenced and negatively valenced interoceptive stimuli, and (2) internally generated interoceptive stimulation using cue reactivity paradigms. The behavioral and brain response characteristics will be examined during: (a) anticipation, (b) stimulation, and (c) post-stimulus processing.
The specific aims are: (1) To determine the status of the interocepfive system in response to positively and negatively valenced interoceptive sfimuli in adults with AD, adults in full sustained remission, and healthy comparison subjects;(2) To determine the sensifivity of the interoceptive system in response to internally generated interoceptive sfimulafion using cue reactivity in AD individuals, those in full sustained remission, and healthy comparison subjects;(3) To modify the neuroimaging paradigms in response to the animal studies (Project 3) and results from Wave 1 human studies to determine whether negafive or positively valenced interocepfive stimulation modulates cue reactivity in AD individuals at various stages of drug use. The clarification of the role of interocepfion and insular cortex functioning in various stages of amphetamine dependence would help to identify a """"""""vulnerability window"""""""" when individuals are at high risk for relapse. Determining whether there is an altered valence-specific sensitivity of the interoceptive system in AD would help to select specific sfimulus materials for cognitive and emotional intervention approaches. Elucidafing the relationship betiA/een interoceptive dysfunctions and other psychological constructs, e.g. craving and selfefficacy, will help to relate interoception to existing theories of drug addiction.
Interoceptive processing or how gut feelings regulate the urge to use is not well understood. Here we examine 3 groups: amphetamine dependent adults, amphetamine dependent adults in remission (>1 year), and non-users on how their brains respond to sfimulafion of gut feelings. Understanding processing differences among these groups will help us to develop new interventions.
|Gowin, Joshua L; Ball, Tali M; Wittmann, Marc et al. (2017) Corrigendum to ""Individualized relapse prediction: Personality measures and striatal and insular activity during reward-processing robustly predict relapse"" [Drug and Alcohol Dependence 152 (2015) 93-101]. Drug Alcohol Depend 175:255|
|Gowin, Joshua L; May, April C; Wittmann, Marc et al. (2017) Doubling down: increased risk-taking behavior following a loss by individuals with cocaine use disorder is associated with striatal and anterior cingulate dysfunction. Biol Psychiatry Cogn Neurosci Neuroimaging 2:94-103|
|Squeglia, Lindsay M; Ball, Tali M; Jacobus, Joanna et al. (2017) Neural Predictors of Initiating Alcohol Use During Adolescence. Am J Psychiatry 174:172-185|
|Mackey, Scott; Olafsson, Valur; Aupperle, Robin L et al. (2016) Greater preference consistency during the Willingness-to-Pay task is related to higher resting state connectivity between the ventromedial prefrontal cortex and the ventral striatum. Brain Imaging Behav 10:730-8|
|Paulus, Martin P; Huys, Quentin J M; Maia, Tiago V (2016) A Roadmap for the Development of Applied Computational Psychiatry. Biol Psychiatry Cogn Neurosci Neuroimaging 1:386-392|
|Harlé, Katia M; Zhang, Shunan; Ma, Ning et al. (2016) Reduced Neural Recruitment for Bayesian Adjustment of Inhibitory Control in Methamphetamine Dependence. Biol Psychiatry Cogn Neurosci Neuroimaging 1:448-459|
|Gowin, Joshua L; Ball, Tali M; Wittmann, Marc et al. (2015) Individualized relapse prediction: Personality measures and striatal and insular activity during reward-processing robustly predict relapse. Drug Alcohol Depend 152:93-101|
|Oosterwijk, Suzanne; Mackey, Scott; Wilson-Mendenhall, Christine et al. (2015) Concepts in context: Processing mental state concepts with internal or external focus involves different neural systems. Soc Neurosci 10:294-307|
|Stewart, Jennifer L; Juavinett, Ashley L; May, April C et al. (2015) Do you feel alright? Attenuated neural processing of aversive interoceptive stimuli in current stimulant users. Psychophysiology 52:249-62|
|Berk, Lotte; Stewart, Jennifer L; May, April C et al. (2015) Under pressure: adolescent substance users show exaggerated neural processing of aversive interoceptive stimuli. Addiction 110:2025-36|
Showing the most recent 10 out of 29 publications