The Clinical and Educational Core (CEC;Core 2) will assume Center-wide responsibility for four major components of the ExCITRA (P20), including: 1) the recruitment, screening, diagnostic assessment, and clinical care of all human research participants;2) the comprehensive neurocognitive assessment of all subjects successfully meeting eligibility criteria;3) the concurrent psychopharmacologic characterization of individuals'subjective, behavioral, and neurocognitive responses to stimulant self-administration (cocaine in cocaine dependent subjects) and/or administration (methylphenidate in cocaine dependent and healthy control subjects);and, 4) the coordination of research career development of affiliated trainees in the interdisciplinary and translational neurobiology of drug addicfion.

Public Health Relevance

The function of the Clinical and Education Core provides direct support to Projects 1 and 2 in the exploratory center and coordinates educational efforts across the enitre Center. Thus the function of the Core is essential to the translational research mission and goals of understanding the neurobiology of drug addiction.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Exploratory Grants (P20)
Project #
5P20DA027844-03
Application #
8380573
Study Section
Special Emphasis Panel (ZDA1-MXS-M)
Project Start
Project End
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
3
Fiscal Year
2012
Total Cost
$166,298
Indirect Cost
$65,816
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
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Schulte, Erica M; Yokum, Sonja; Potenza, Marc N et al. (2016) Neural systems implicated in obesity as an addictive disorder: from biological to behavioral mechanisms. Prog Brain Res 223:329-46
Pitts, Elizabeth G; Taylor, Jane R; Gourley, Shannon L (2016) Prefrontal cortical BDNF: A regulatory key in cocaine- and food-reinforced behaviors. Neurobiol Dis 91:326-35
Balodis, Iris M; Kober, Hedy; Worhunsky, Patrick D et al. (2016) Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery. Neuropsychopharmacology 41:2112-21
Gogliettino, Alex R; Potenza, Marc N; Yip, Sarah W (2016) White matter development and tobacco smoking in young adults: A systematic review with recommendations for future research. Drug Alcohol Depend 162:26-33
Gourley, Shannon L; Zimmermann, Kelsey S; Allen, Amanda G et al. (2016) The Medial Orbitofrontal Cortex Regulates Sensitivity to Outcome Value. J Neurosci 36:4600-13

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