A large and growing literature links exposure to chemicals during specific periods of fetal development with: adverse birth outcomes, such as preterm delivery and low birthweight;childhood illnesses, such as neurodevelopmental disorders and cancer;and later onset of adult disorders, such as diabetes and cardiovascular disease. In addition, large national biomonitoring studies are reporting nearly ubiquitous exposure to numerous environmental contaminants in the US population, raising the question of how exactly people are being exposed and what are the implications. Furthermore, studies of mid-gestation pregnancies confirm that the placenta does not act as a barrier to exogenous chemicals and also indicate that the fetus - at a time when it lacks detoxifying mechanisms - may experience higher levels of exposure than the mother. We propose to assemble a new, integrated, multidisciplinary group of researchers from the biological, clinical and epidemiologic sciences into the UCSF Pregnancy Exposures and Environmental Contaminants Formative Center. The theme of the PEEC Formative Center is to advance our understanding of how exposure to environmental chemicals affects early development using an innovative multidisciplinary approach that 1) integrates research on sources and exposures to environmental chemicals during pregnancy with basic biological research on how chemical exposures may disrupt early development and 2) translates these scientific findings to healthcare providers, policy makers and community groups in order to improve clinical care and promote policies that prevent prenatal exposures to harmful chemicals. Our long term goals are to develop novel techniques for early identification of harmful exposures, to devise novel strategies for the prevention of environmentally mediated diseases, to develop new relationships with health care professionals and community groups to transmit scientific information about the effect of environmental contaminants on early development, and to inspire career choice and advocacy in this important area of prenatal environmental health and research.

Public Health Relevance

We will assemble a multidisciplinary team of researchers to advance our understanding of sources and exposures to environmental chemicals during pregnacy and understand how exposures to chemicals may disrupt early development. We wil translate these findings to healthcare providers, policy makers and community groups to improve clinical care and public policies to prevent harmful exposures.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Exploratory Grants (P20)
Project #
5P20ES018135-03
Application #
8228031
Study Section
Special Emphasis Panel (ZES1-LKB-G (TW))
Program Officer
Gray, Kimberly A
Project Start
2010-05-05
Project End
2014-01-31
Budget Start
2012-02-01
Budget End
2014-01-31
Support Year
3
Fiscal Year
2012
Total Cost
$230,875
Indirect Cost
$56,938
Name
University of California San Francisco
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Koustas, Erica; Lam, Juleen; Sutton, Patrice et al. (2014) The Navigation Guide - evidence-based medicine meets environmental health: systematic review of nonhuman evidence for PFOA effects on fetal growth. Environ Health Perspect 122:1015-27
Woodruff, Tracey J; Sutton, Patrice (2014) The Navigation Guide systematic review methodology: a rigorous and transparent method for translating environmental health science into better health outcomes. Environ Health Perspect 122:1007-14
Lam, Juleen; Koustas, Erica; Sutton, Patrice et al. (2014) The Navigation Guide - evidence-based medicine meets environmental health: integration of animal and human evidence for PFOA effects on fetal growth. Environ Health Perspect 122:1040-51
Vandenberg, Laura N; Gerona, Roy R; Kannan, Kurunthachalam et al. (2014) A round robin approach to the analysis of bisphenol A (BPA) in human blood samples. Environ Health 13:25
Gerona, Roy R; Woodruff, Tracey J; Dickenson, Carrie A et al. (2013) Bisphenol-A (BPA), BPA glucuronide, and BPA sulfate in midgestation umbilical cord serum in a northern and central California population. Environ Sci Technol 47:12477-85
Sutton, Patrice; Wallinga, David; Perron, Joanne et al. (2011) Reproductive health and the industrialized food system: a point of intervention for health policy. Health Aff (Millwood) 30:888-97
Woodruff, Tracey J; Sutton, Patrice; Navigation Guide Work Group (2011) An evidence-based medicine methodology to bridge the gap between clinical and environmental health sciences. Health Aff (Millwood) 30:931-7