Pregnant women are exposed to endocrine disrupting chemicals such as phthalates and bisphenol A (BPA) through their use of personal care products and plastics. In animal models, phthalates and BPA cause developmental abnormalities, but littie is known about whether these chemicals are associated with adverse developmental outcomes in humans. The proposed pilot study will develop novel methods to assess the impact of prenatal BPA or phthalate exposure on sexually dimorphic physical and behavioral endpoints during the first few months of life and it will identify reliable and valid measures of cognitive function in newborns that are sensitive to prenatal chemical exposure and predictive of lasting cognitive deficits. The overall hypothesis of the proposed pilot study is that maternal exposure to phthalates and/or BPA is associated with adverse developmental outcomes in their offspring. The specific objectives of the proposed project are to: 1) assess exposure to phthalates and BPA in a sample of pregnant women, 2) examine the association between prenatal phthalate and BPA exposure and physical development in infants, 3) examine the association between prenatal phthalate and BPA exposure and cognition in infants, and 4) investigate whether polymorphisms in estrogen receptor (ER) alpha and ER beta increase susceptibility to prenatal phthalate or BPA exposure. To complete the proposed work. 150 pregnant women age 18-40 and their infants will be recruited from a local hospital. The pregnant women will complete a 24-hour product use diary and provide urine samples for assessments of total BPA and 9 phthalate metabolites. In addition, pregnant women will donate cord blood for measurement of selected ER polymorphisms. Key physical and cognitive outcomes will be assessed at birth, and cognitive outcomes will also be assessed at 4.5 and 7.5 months of age. The relationship behween measures of exposure and reported product use, and the relationship behween maternal exposures and physical or cognitive outcomes in infants will be examined in statistical regression models. The proposed study will provide important pilot data about the nature of phthalate and BPA exposure in pregnant women and the risk of developmental abnormalities in their infants. The results will provide a strong basis for expansion of the pilot birth cohort into a larger prospective birth cohort with longitudinal follow-up of the children from birth through puberty.

Public Health Relevance

The proposed study will provide important pilot data about the nature of phthalate and BPA exposure in pregnant women and the risk of developmental abnormalities in their infants. The results will provide a strong basis for a future center proposal to expand the pilot study into a larger prospective birth cohort study assessing the effects of prenatal exposure to these chemicals on development of children.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Exploratory Grants (P20)
Project #
5P20ES018163-02
Application #
8208664
Study Section
Special Emphasis Panel (ZES1)
Project Start
2010-12-01
Project End
2012-11-30
Budget Start
2010-12-01
Budget End
2011-11-30
Support Year
2
Fiscal Year
2011
Total Cost
$61,785
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Type
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Wise, Leslie M; Sadowski, Renee N; Kim, Taehyeon et al. (2016) Long-term effects of adolescent exposure to bisphenol A on neuron and glia number in the rat prefrontal cortex: Differences between the sexes and cell type. Neurotoxicology 53:186-192
Ziv-Gal, Ayelet; Wang, Wei; Zhou, Changqing et al. (2015) The effects of in utero bisphenol A exposure on reproductive capacity in several generations of mice. Toxicol Appl Pharmacol 284:354-62
Sadowski, R N; Wise, L M; Park, P Y et al. (2014) Early exposure to bisphenol A alters neuron and glia number in the rat prefrontal cortex of adult males, but not females. Neuroscience 279:122-31
Peretz, Jackye; Vrooman, Lisa; Ricke, William A et al. (2014) Bisphenol a and reproductive health: update of experimental and human evidence, 2007-2013. Environ Health Perspect 122:775-86
Sadowski, Renee N; Park, Pul; Neese, Steven L et al. (2014) Effects of perinatal bisphenol A exposure during early development on radial arm maze behavior in adult male and female rats. Neurotoxicol Teratol 42:17-24
Peretz, Jackye; Neese, Steven L; Flaws, Jodi A (2013) Mouse strain does not influence the overall effects of bisphenol a-induced toxicity in adult antral follicles. Biol Reprod 89:108
Peretz, Jackye; Flaws, Jodi A (2013) Bisphenol A down-regulates rate-limiting Cyp11a1 to acutely inhibit steroidogenesis in cultured mouse antral follicles. Toxicol Appl Pharmacol 271:249-56
Liu, Chang; Paczkowski, Melissa; Othman, Manal et al. (2012) Investigating the origins of somatic cell populations in the perinatal mouse ovaries using genetic lineage tracing and immunohistochemistry. Methods Mol Biol 825:211-21
Peretz, Jackye; Craig, Zelieann R; Flaws, Jodi A (2012) Bisphenol A inhibits follicle growth and induces atresia in cultured mouse antral follicles independently of the genomic estrogenic pathway. Biol Reprod 87:63
Brannick, Katherine E; Craig, Zelieann R; Himes, Ashley D et al. (2012) Prenatal exposure to low doses of bisphenol A increases pituitary proliferation and gonadotroph number in female mice offspring at birth. Biol Reprod 87:82

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