A Biostatistics Core (BC) is being developed to provide a series of functions that are central to the goals of the Berkeley/Stanford Children's Environment Health (Pre)-Center (CHP-C). Two of the functions can be considered generic to any research center and one is unique to the CHP-C. The two generic functions are: 1) to work in collaboration with the data management team to assure the quality of the data that are used for all analyses by all investigators; and 2) to provide statistical input required for all data analyses being carried out by all investigators. The unique goal is to continue the work that has been done by the PI and his statistical collaborators in the application of causal statistical methods (CSMs) various applications of marginal structural models (MSMs) to environmental health research. As will be explained below, this latter collaboration involves the application of evolving methods to estimate causal parameters and the development of user-friendly and computationally efficient software. Application of causal statistical methods has facilitated analyses that heretofore were not addressed appropriately by more

Public Health Relevance

The Biostatistics Core (BC) is highly relevant to our Pre-Center. One of the novel aspects and great strengths of our application is the centrality that will give to use of causal statistical methods (CSMs) for our analyses. Thus, the analyses that will be undertaken by the BC all will be first of their kind in the study of environmental toxicant effects on birth outcomes and will provide overall population effect estimates.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Exploratory Grants (P20)
Project #
5P20ES018173-02
Application #
8215036
Study Section
Special Emphasis Panel (ZES1)
Project Start
2011-02-01
Project End
2013-01-31
Budget Start
2011-02-01
Budget End
2012-01-31
Support Year
2
Fiscal Year
2011
Total Cost
$17,525
Indirect Cost
Name
University of California Berkeley
Department
Type
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
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Padula, Amy M; Yang, Wei; Carmichael, Suzan L et al. (2017) Air pollution, neighborhood acculturation factors, and neural tube defects among Hispanic women in California. Birth Defects Res 109:403-422
Noth, Elizabeth M; Lurmann, Fred; Northcross, Amanda et al. (2016) Spatial and Temporal Distribution of Polycyclic Aromatic Hydrocarbons and Elemental Carbon in Bakersfield, California. Air Qual Atmos Health 9:899-908
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Padula, Amy M; Mortimer, Kathleen M; Tager, Ira B et al. (2014) Traffic-related air pollution and risk of preterm birth in the San Joaquin Valley of California. Ann Epidemiol 24:888-95e4
Padula, Amy M; Noth, Elizabeth M; Hammond, S Katharine et al. (2014) Exposure to airborne polycyclic aromatic hydrocarbons during pregnancy and risk of preterm birth. Environ Res 135:221-6
Syed, Aleena; Garcia, Marco A; Lyu, Shu-Chen et al. (2014) Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3). J Allergy Clin Immunol 133:500-10

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