The Administrative Core of the Center for Children's Environmental Health at Dartmouth will support the overall goals and objectives of the Center by providing the services necessary to integrate the required components of the proposed formative center. In this capacity, the Administrative Core will serve as the central coordinating body for all executive and managerial functions, research, career development and training programs, communications with internal and external sources and for the coordination of general resources needed to support research and outreach/translational activities. The Core will establish procedures for the day to day functions of the Center and will provide oversight and coordination of planning and evaluation activities to ensure successful progress toward full integration of cross-disciplinary research activities and establishment of the Center as a comprehensive resource for children's environmental health and disease prevention research both regionally and nationally. The Core will consist of a Director, Associate Director, Children's Health Specialist, Coordinator, Associate Children's Health Specialist, Administrative Assistant and Budget Manager. An External Advisory Board of nationally and regionally recognized experts in children's environmental health and disease prevention will be established and will provide consultation, oversight and evaluation to support the Center. The Core will work toward establishing a Community Outreach and Translation Core during this formative phase of the Center. The Core will coordinate and support a Community Outreach Team comprised of Center members. This team and the Core will develop a Community Advisory Board to actively participate in decision making, and provide consumer input and guidance for Center activities, around translational efforts and future research needs of relevance to New Hampshire communities. Public Health Relevance: The Children's Center for Environmental Health at Dartmouth will fill critical gaps in our understanding of the role of drinking water and food borne exposure to arsenic and other contaminants (e.g. cadmium and mercury.) on fetal development and maternal/infant immune function. The Administrative Core of the Center will support this goal by providing the services necessary to integrate the research and activities of the Center.

Public Health Relevance

We propose an integrated center comprised of a talented and diverse team to address emerging areas of concern, including the potential for significant exposure to arsenic in infant's food as well as water. Based on available evidence, these exposure could impact susceptibility to infection and vaccine response and disrupt major pathways involved in human development resulting in birth defects.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZES1-LKB-G (P2))
Program Officer
Gray, Kimberly A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Dartmouth College
Family Medicine
Schools of Medicine
United States
Zip Code
Davis, Matthew A; Li, Zhigang; Gilbert-Diamond, Diane et al. (2014) Infant toenails as a biomarker of in utero arsenic exposure. J Expo Sci Environ Epidemiol 24:467-73
Punshon, Tracy; Tappero, Ryan; Ricachenevsky, Felipe K et al. (2013) Contrasting calcium localization and speciation in leaves of the Medicago truncatula mutant cod5 analyzed via synchrotron X-ray techniques. Plant J 76:627-33
Farzan, Shohreh F; Korrick, Susan; Li, Zhigang et al. (2013) In utero arsenic exposure and infant infection in a United States cohort: a prospective study. Environ Res 126:24-30
Koestler, Devin C; Avissar-Whiting, Michele; Houseman, E Andres et al. (2013) Differential DNA methylation in umbilical cord blood of infants exposed to low levels of arsenic in utero. Environ Health Perspect 121:971-7
Cottingham, Kathryn L; Karimi, Roxanne; Gruber, Joann F et al. (2013) Diet and toenail arsenic concentrations in a New Hampshire population with arsenic-containing water. Nutr J 12:149
Koestler, Devin C; Christensen, Brock; Karagas, Margaret R et al. (2013) Blood-based profiles of DNA methylation predict the underlying distribution of cell types: a validation analysis. Epigenetics 8:816-26
Shi, Xun; Miller, Stephanie; Mwenda, Kevin et al. (2013) Mapping disease at an approximated individual level using aggregate data: a case study of mapping New Hampshire birth defects. Int J Environ Res Public Health 10:4161-74
Wilhelm-Benartzi, C S; Koestler, D C; Karagas, M R et al. (2013) Review of processing and analysis methods for DNA methylation array data. Br J Cancer 109:1394-402
Farzan, Shohreh F; Karagas, Margaret R; Chen, Yu (2013) In utero and early life arsenic exposure in relation to long-term health and disease. Toxicol Appl Pharmacol 272:384-90
Fei, Dennis Liang; Koestler, Devin C; Li, Zhigang et al. (2013) Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study. Environ Health 12:58

Showing the most recent 10 out of 18 publications