The Biomedical Informatics Core in IDeA Network for Biomedical Research Excellence (INBRE)3 will increase access to biomedical informatics resources and expertise both on- and off-site by facilitating a distributed core to enable training and the use of biomedical informatics in INBRE research. By appointing a biostatistician with clinical research experience as Lead ofthe Biomedical Informatics core, and by providing biostatistical support via consultants, we will increase the basic and translational research capacity ofthe INBRE faculty at University of Alaska (UA). To meet the full range of biomedical informatics needs at UA, particularly those needs that go beyond our current capacity, we will make funding available for contractual services with expert biomedical informatcians and programmers in specialized fields. We will target western INBRE biomedical informatics sites for collaborative contractual services and exchange of expertise. As a part of these contractual services, we will leverage our position and association with INBRE, to require contractors to provide our group with introductions and talk to our researchers about the services they are providing, as well as follow-up consultations after the work has been done. The Biomedical Informatics core will also provide training opportunities and pilot award funding for project utilizing biomedical informatics technologies. Trainees, post-docs, staff and faculty members will be invited to attend formal biomedical informatics workshops, and to visit other institutions/collaborators with specialized expertise. The Core will offer 2 week intramural biomedical informatics workshops on the UA Fairbanks campus. Further, we plan yearly competitions for multiple pilot awards that will enable researcher to initiate projects that require advanced biomedical informatics resources, such as next generation sequencing technology and/or proteomics or metabolomics profiling. Recruiting a biostatistician with clinical experience as director ofthe core, and providing biostatistical support via consultants, will increase the translational research capacity of bioinformatics at UA. By accomplishing these goals, we will enhance collaboration with other western IDeA states as well as build bioinformatics and enhace translational research capacity at UA.

Public Health Relevance

Cutting-edge bioinformatics technology is essential for contemporary biomedical research. Increasing access to bioinformatics resources/expertise off and on-site via collaboration with University of Washington and recruitrnent of support staff to run systems at UA, we will enable training and use of a bioinformatics approach in INBRE research.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-TWD-7 (IN))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Alaska Fairbanks
United States
Zip Code
Leewis, Mary-Cathrine; Uhlik, Ondrej; Leigh, Mary Beth (2016) Synergistic Processing of Biphenyl and Benzoate: Carbon Flow Through the Bacterial Community in Polychlorinated-Biphenyl-Contaminated Soil. Sci Rep 6:22145
Beltran, Roxanne S; Peterson, Sarah H; McHuron, Elizabeth A et al. (2016) Seals and sea lions are what they eat, plus what? Determination of trophic discrimination factors for seven pinniped species. Rapid Commun Mass Spectrom 30:1115-22
Leewis, Mary-Cathrine; Uhlik, Ondrej; Fraraccio, Serena et al. (2016) Differential Impacts of Willow and Mineral Fertilizer on Bacterial Communities and Biodegradation in Diesel Fuel Oil-Contaminated Soil. Front Microbiol 7:837
Wade, Michael J; Drown, Devin M (2016) Nuclear-mitochondrial epistasis: a gene's eye view of genomic conflict. Ecol Evol 6:6460-6472
Goldsmith, Elizabeth W; Renshaw, Benjamin; Clement, Christopher J et al. (2016) Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska. Mol Ecol 25:675-88
Scerbak, Courtney; Vayndorf, Elena M; Hernandez, Alicia et al. (2016) Mechanosensory Neuron Aging: Differential Trajectories with Lifespan-Extending Alaskan Berry and Fungal Treatments in Caenorhabditis elegans. Front Aging Neurosci 8:173
Porcu, P; Barron, A M; Frye, C A et al. (2016) Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research. J Neuroendocrinol 28:12351
Mann, K; Kullberg, M (2016) Trastuzumab-targeted gene delivery to Her2-overexpressing breast cancer cells. Cancer Gene Ther 23:221-8
Simons, Brenna C; Spradling, Philip R; Bruden, Dana J T et al. (2016) A Longitudinal Hepatitis B Vaccine Cohort Demonstrates Long-lasting Hepatitis B Virus (HBV) Cellular Immunity Despite Loss of Antibody Against HBV Surface Antigen. J Infect Dis 214:273-80
Glenn, Travis C; Faircloth, Brant C (2016) Capturing Darwin's dream. Mol Ecol Resour 16:1051-8

Showing the most recent 10 out of 69 publications