The University of Kansas Medical Center (KUMC) here presents an application for continued support for the Kansas IDeA Network for Biomedical Research Excellence (K-INBRE). The K-INBRE links KUMC (Lead Institution) with the two other major doctoral-degree-granting institutions in Kansas (University of Kansas- Lawrence, KU-L;Kansas State University, KSU) as Graduate Partner Institutions (GPI) and with seven Undergraduate Partner Institutions (UPI). UPI include six Kansas undergraduate campuses (Emporia State University, Ft. Hays State University, Haskell Indian Nations University, Pittsburg State University, Washburn University, Wichita State University) and Langston University (Langston, OK). Haskell Indian Nations University and Langston University increase diversity in the network as the first is devoted to education and training of native Americans and the second enrolls primarily black undergraduates. The long-range objective of the Kansas program is to strengthen the state's research capacity in Cell and Developmental Biology by building on the successes of the current K-INBRE. The size, structure and operational principles of the K-INBRE, which include strong emphasis on training for biomedical research, networking and intercampus communication and the establishment of a sophisticated bioinformatics program, were established during the previous years of support. These goals remain basically the same as the K-INBRE has had a major positive impact on biomedical research in the State of Kansas. Programs conducted by the K-INBRE have had measurable success in reaching their stated goals as well as those of the NCRR IDeA program.
The Specific Aims proposed for the next phase of the K-INBRE are to (1) maintain and improve the current multi-disciplinary research network in Cell and Developmental Biology with efficient administration and focus on networking, (2) enhance science and technology knowledge and integration by offering sophisticated bioinformatics technology and education, (3) facilitate translational research via bidirectional exchange of basic and clinical scientist training opportunities. Within these Aims, new features that improve the K-INBRE include broadening funding for research careers together with improvements in oversight and the mentoring process, promoting an integrated systems biology approach within our bioinformatics network, and incorporating training for translational research into the K-INBRE goals so as to smooth the progress of scientific discoveries into the clinical arena.
Research in cell and developmental biology is essential to advancing our understanding of cellular processes of health and disease. Such research relies on generation of a strong, well educated workforce, ready availability of the tools of discovery and emphasis on applying the results of discovery research to problems of human health. In building a distinguished center of research in cell and developmental biology in Kansas, the K-INBRE vigorously pursues all three of these key strategies.
|Raider, Kayla; Ma, Delin; Harris, Janna L et al. (2016) A high fat dietÂ alters metabolic and bioenergetic function in the brain: A magnetic resonance spectroscopy study. Neurochem Int 97:172-80|
|Kim, Stephanie; Eliot, Melissa; Koestler, Devin C et al. (2016) Enlarged leukocyte referent libraries can explain additional variance in blood-based epigenome-wide association studies. Epigenomics 8:1185-92|
|Wilson, Nathan R; Olm-Shipman, Adam J; Acevedo, Diana S et al. (2016) SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination. Sci Rep 6:17735|
|Maitra, Soma; Bodugam, Mahipal; Javed, Salim et al. (2016) Synthesis of the C9-C25 Subunit of Spirastrellolide B. Org Lett 18:3094-7|
|Nishimune, Hiroshi; Badawi, Yomna; Mori, Shuuichi et al. (2016) Dual-color STED microscopy reveals a sandwich structure of Bassoon and Piccolo in active zones of adult and aged mice. Sci Rep 6:27935|
|Maddukuri, Naveen; Zhang, Qiyang; Zhang, Ning et al. (2016) Rapid labelling of amino neurotransmitters with a fluorescent thiol in the presence of o-phthalaldehyde. Electrophoresis :|
|Josephson, Matthew P; Chai, Yongping; Ou, Guangshuo et al. (2016) EGL-20/Wnt and MAB-5/Hox Act Sequentially to Inhibit Anterior Migration of Neuroblasts in C. elegans. PLoS One 11:e0148658|
|Wang, Yazhen; Southard, Kristopher M; Zeng, Yong (2016) Digital PCR using micropatterned superporous absorbent array chips. Analyst 141:3821-31|
|Koestler, Devin C; Jones, Meaghan J; Usset, Joseph et al. (2016) Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL). BMC Bioinformatics 17:120|
|Wang, Huizhen; May, Jacob; Butnev, Viktor et al. (2016) Evaluation of inÂ vivo bioactivities of recombinant hypo- (FSH(21/18)) and fully- (FSH(24)) glycosylated human FSH glycoforms in Fshb null mice. Mol Cell Endocrinol 437:224-236|
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