The University of Kansas Medical Center (KUMC) presents an application for continued support for the Kansas IDeA Network for Biomedical Research Excellence (K-INBRE). The K-INBRE links KUMC (Lead Institution) with the two major doctoral-degree-granting institutions in Kansas (University of Kansas-Lawrence, KU-L;Kansas State Univ., KSU) as Graduate Partner Institutions (GPIs), and with seven Undergraduate Partner Institutions (UPls). UPls include six Kansas undergraduate campuses (Emporia State Univ., Ft. Hays State Univ., Haskell Indian Nations Univ., Pittsburg State Univ., Washburn Univ., Wichita State Univ.) and Langston Univ. (Langston, OK). Haskell Indian Nations Univ. and Langston Univ. increase diversity in the network as the first is devoted to education and training of native Americans and the second enrolls primarily black undergraduates. The long-range objective of the Kansas program is to strengthen the state's research capacity in Cell and Developmental Biology by building on the successes of the current K-INBRE. The structure and operational principles of the K-INBRE, which focus on training for biomedical research, networking and intercampus communication and the presence of a sophisticated bioinformatics program, were established during the previous years. These goals remain similar as the KINBRE has had a significant impact on biomedical research in the State of Kansas, but novel programs are tailored to fit new emerging areas associated with translational research. Programs conducted by the KINBRE have had measurable success in reaching their stated goals.
The Specific Aims proposed for the next phase of the K-INBRE are to (1) maintain and improve the current multi-disciplinary research network in Cell and Developmental Biology in the State of Kansas, strengthening both communication channels and research infrastructure, (2) enhance science and technology knowledge and integration in Kansas by offering sophisticated bioinformatics technology and education, (3) stimulate basic and translational research in the State of Kansas via mentored, interdisciplinary research opportunities. Within these Aims, new features that improve the K-INBRE include broadening funding for research careers together with improvements in oversight and the mentoring process, promoting an integrated systems biology approach within our bioinformatics network, and incorporating training for translational research into the K-INBRE goals so as to smooth the progress of scientific discoveries into the clinical arena.
Research in cell and developmental biology is essential to advancing our understanding of cellular processes of health and disease. Such research relies on generation of a strong, well educated workforce, ready availability of the tools of discovery and emphasis on applying the results of discovery research to problems of human health. In building a distinguished center of research in cell and developmental biology in Kansas, the K-INBRE vigorously pursues all three of these key strategies.
|Wang, Huijing; Ray, J Christian J (2017) Dynamical predictors of an imminent phenotypic switch in bacteria. Phys Biol 14:045007|
|Jasti, Susmita; Farahbakhsh, Mina; Nguyen, Sean et al. (2017) Immune response to a model shared placenta/tumor-associated antigen reduces cancer risk in parous mice. Biol Reprod 96:134-144|
|Deschamps, Thibaut; Kalamvoki, Maria (2017) Impaired STING Pathway in Human Osteosarcoma U2OS Cells Contributes to the Growth of ICP0-Null Mutant Herpes Simplex Virus. J Virol 91:|
|Fu, Xian; Adams, Zachary; Liu, Rui et al. (2017) Methionine Sulfoxide Reductase A (MsrA) and Its Function in Ubiquitin-Like Protein Modification in Archaea. MBio 8:|
|Ishiguro, Susumu; Alhakamy, Nabil A; Uppalapati, Deepthi et al. (2017) Combined Local Pulmonary and Systemic Delivery of AT2R Gene by Modified TAT Peptide Nanoparticles Attenuates Both Murine and Human Lung Carcinoma Xenografts in Mice. J Pharm Sci 106:385-394|
|Coyne, Alyssa N; Lorenzini, Ileana; Chou, Ching-Chieh et al. (2017) Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS. Cell Rep 21:110-125|
|Koestler, Devin C; Usset, Joseph; Christensen, Brock C et al. (2017) DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio: An Epigenetic Tool to Explore Cancer Inflammation and Outcomes. Cancer Epidemiol Biomarkers Prev 26:328-338|
|Ma, Delin; Shuler, Jeffrey M; Kumar, Aishwarya et al. (2017) Effects of Tongue Force Training on Bulbar Motor Function in the Female SOD1-G93A Rat Model of Amyotrophic Lateral Sclerosis. Neurorehabil Neural Repair 31:147-156|
|Lal, Shruti; Cheung, Edwin C; Zarei, Mahsa et al. (2017) CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype. Mol Cancer Res 15:696-707|
|Cooper, Michael A; Ryals, Janelle M; Wu, Pau-Yen et al. (2017) Modulation of diet-induced mechanical allodynia by metabolic parameters and inflammation. J Peripher Nerv Syst 22:39-46|
Showing the most recent 10 out of 329 publications