The proposed Maine IDeA Network of Biomedical Research Excellence (ME-INBRE) in comparative functional genomics is led by the Mount Desert Island Biological Laboratory and is composed of two research institutions, one graduate degree granting institution, seven undergraduate institutions and one community college. ME-INBRE, with the expertise, strengths, and research resources of its research institutions, and the strong commitment of all its institutions to building research capacity in Maine, is uniquely positioned to exploit the power of comparative functional genomics to discover important information about the genetic properties and function of genes of diverse species, and to use this topic as the scientific focus for institutional development, research training, and career development. ME-INBRE is having an unprecedented impact in our state by creating a new baseline of excellence in biomedical research and training, which already has enhanced the career development of investigators, substantially increased undergraduate student interest and accomplishments in science and health-related careers, and enhanced research infrastructure. Furthermore, we have created a stable and effective organizational structure capable of growing with ME-INBRE in the next grant period. The proposed INBRE builds on this structure to 1) increase the number of ME-INBRE undergraduate institutions from four to seven and include one college from Maine's community college system established n 2003, 2) establish eight new investigator research projects, 3) expand support for graduate students from The University of Maine's Graduate School of Biomedical Sciences established in 2006, 4) extend outreach to undergraduate students in northern Maine, 5) create a new outreach program for high school students, and 6) significantly expand state, regional, and national collaborations.

Public Health Relevance

Research and training in comparative functional genomics will lead to a better understanding of mechanisms that control expression of genes that have significant roles in physiology, pharmacology, development, regeneration, and disease resistance and treatment. Maine INBRE will be a pipeline for students and faculty to pursue health research careers, and will enhance institutional development and scientific knowledge.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103423-13
Application #
8460507
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Program Officer
Taylor, Fred
Project Start
2001-09-30
Project End
2014-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
13
Fiscal Year
2013
Total Cost
$3,478,086
Indirect Cost
$649,961
Name
Mount Desert Island Biological Lab
Department
Type
DUNS #
077470003
City
Salsbury Cove
State
ME
Country
United States
Zip Code
04672
Yin, Viravuth P (2018) In Situ Detection of MicroRNA Expression with RNAscope Probes. Methods Mol Biol 1649:197-208
Ulin, Alexandra; Henderson, Jake; Pham, Minh-Tam et al. (2018) Developmental Regulation of Nuclear Factor Erythroid-2 Related Factors (nrfs) by AHR1b in zebrafish (Danio rerio). Toxicol Sci :
Hersh, Taylor A; Dimond, Alexandria L; Ruth, Brittany A et al. (2018) A role for the CXCR4-CXCL12 axis in the little skate, Leucoraja erinacea. Am J Physiol Regul Integr Comp Physiol 315:R218-R229
Yue, S; Wadia, V; Sekula, N et al. (2018) Acute effects of sex steroids on visual processing in male goldfish. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 204:17-29
King, Benjamin L; Rosenstein, Michael C; Smith, Ashley M et al. (2018) RegenDbase: a comparative database of noncoding RNA regulation of tissue regeneration circuits across multiple taxa. NPJ Regen Med 3:10
Jacobs, Haydee M; Sant, Karilyn E; Basnet, Aviraj et al. (2018) Embryonic exposure to Mono(2-ethylhexyl) phthalate (MEHP) disrupts pancreatic organogenesis in zebrafish (Danio rerio). Chemosphere 195:498-507
Silvestri, Vanesa L; Millard, Julie T (2018) Changes in apoptotic gene expression induced by the DNA cross-linkers epichlorohydrin and diepoxybutane in human cell lines. Data Brief 19:932-935
Stefanelli, Gilda; Azam, Amber B; Walters, Brandon J et al. (2018) Learning and Age-Related Changes in Genome-wide H2A.Z Binding in the Mouse Hippocampus. Cell Rep 22:1124-1131
Ye, Jiayu; Farrington, Caitlin R; Millard, Julie T (2018) Polymerase bypass of N7-guanine monoadducts of cisplatin, diepoxybutane, and epichlorohydrin. Mutat Res 809:6-12
Weatherly, Lisa M; Nelson, Andrew J; Shim, Juyoung et al. (2018) Antimicrobial agent triclosan disrupts mitochondrial structure, revealed by super-resolution microscopy, and inhibits mast cell signaling via calcium modulation. Toxicol Appl Pharmacol 349:39-54

Showing the most recent 10 out of 199 publications