The proposed Maine IDeA Network of Biomedical Research Excellence (ME-INBRE) in comparative functional genomics is led by the Mount Desert Island Biological Laboratory and is composed of two research institutions, one graduate degree granting institution, seven undergraduate institutions and one community college. ME-INBRE, with the expertise, strengths, and research resources of its research institutions, and the strong commitment of all its institutions to building research capacity in Maine, is uniquely positioned to exploit the power of comparative functional genomics to discover important information about the genetic properties and function of genes of diverse species, and to use this topic as the scientific focus for institutional development, research training, and career development. ME-INBRE is having an unprecedented impact in our state by creating a new baseline of excellence in biomedical research and training, which already has enhanced the career development of investigators, substantially increased undergraduate student interest and accomplishments in science and health-related careers, and enhanced research infrastructure. Furthermore, we have created a stable and effective organizational structure capable of growing with ME-INBRE in the next grant period. The proposed INBRE builds on this structure to 1) increase the number of ME-INBRE undergraduate institutions from four to seven and include one college from Maine's community college system established n 2003, 2) establish eight new investigator research projects, 3) expand support for graduate students from The University of Maine's Graduate School of Biomedical Sciences established in 2006, 4) extend outreach to undergraduate students in northern Maine, 5) create a new outreach program for high school students, and 6) significantly expand state, regional, and national collaborations.

Public Health Relevance

Research and training in comparative functional genomics will lead to a better understanding of mechanisms that control expression of genes that have significant roles in physiology, pharmacology, development, regeneration, and disease resistance and treatment. Maine INBRE will be a pipeline for students and faculty to pursue health research careers, and will enhance institutional development and scientific knowledge.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Program Officer
Taylor, Fred
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Mount Desert Island Biological Lab
Salsbury Cove
United States
Zip Code
Liao, Jennifer; Morin, Laura W; Ahmad, S Tariq (2014) Methods to characterize spontaneous and startle-induced locomotion in a rotenone-induced Parkinson's disease model of Drosophila. J Vis Exp :
Tra, Van N; Dube, Danielle H (2014) Glycans in pathogenic bacteria--potential for targeted covalent therapeutics and imaging agents. Chem Commun (Camb) 50:4659-73
Shaw, Joseph R; Hampton, Thomas H; King, Benjamin L et al. (2014) Natural selection canalizes expression variation of environmentally induced plasticity-enabling genes. Mol Biol Evol 31:3002-15
Kohorn, Bruce D; Kohorn, Susan L; Saba, Nicholas J et al. (2014) Requirement for pectin methyl esterase and preference for fragmented over native pectins for wall-associated kinase-activated, EDS1/PAD4-dependent stress response in Arabidopsis. J Biol Chem 289:18978-86
Field, Daniel J; Gauthier, Jacques A; King, Benjamin L et al. (2014) Toward consilience in reptile phylogeny: miRNAs support an archosaur, not lepidosaur, affinity for turtles. Evol Dev 16:189-96
Wyffels, Jennifer; King, Benjamin L; Vincent, James et al. (2014) SkateBase, an elasmobranch genome project and collection of molecular resources for chondrichthyan fishes. F1000Res 3:191
Gratacap, Remi L; Bergeron, Audrey C; Wheeler, Robert T (2014) Modeling mucosal candidiasis in larval zebrafish by swimbladder injection. J Vis Exp :e52182
Stone, Judy L; VanWyk, Emily J; Hale, Jennifer R (2014) Transmission advantage favors selfing allele in experimental populations of self-incompatible Witheringia solanacea (solanaceae). Evolution 68:1845-55
Ji, Weidong; Yang, Mei; Praggastis, Alexandra et al. (2014) Carbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell death. PLoS One 9:e103224
Bavis, Ryan W; van Heerden, Eliza S; Brackett, Diane G et al. (2014) Postnatal development of eupneic ventilation and metabolism in rats chronically exposed to moderate hyperoxia. Respir Physiol Neurobiol 198:1-12

Showing the most recent 10 out of 36 publications