The goal ofthe Developmental Research Project Program ofthe Maine INBRE (ME-INBRE) is to support the research and career development of exceptional INBRE-affiliated faculty who are engaged in biomedical research and research training focused on the unifying theme of comparative functional genomics. Faculty will be selected on a competitive basis, via review by the ME-INBRE External Advisory Committee (EAC), from applicants who respond to Funding Opportunity Announcements (FOA) distributed within the MEINBRE network. This program has two specific aims. The first is to provide research funding and mentorship for ME-INBRE Investigators. Selected Investigators will be expected to devote 50% effort to their proposed research project, actively engage mentors and implement individualized development plans, mentor students and/or postdoctoral fellows, submit quarterly progress reports, publish in peer-reviewed journals, present at national and/or international meetings, and participate in INBRE-sponsored workshops. Investigators at research institutions will also be expected to apply for independent ROI-level research funding by the end of the second year of funding. Investigator appointments will be renewed annually for up to 5 years contingent on review of progress by the ME-INBRE Principal Investigator (PI), Program Coordinator (PC), and EAC.
The second aim of the program is to provide more opportunities for faculty-led research and training on site at primarily undergraduate (partner) institutions. This will be accomplished by granting Research Training Faculty awards to selected faculty who have demonstrated an ability to effectively engage students in cutting-edge research related to the theme of this INBRE. Research Training Faculty will devote 15-25% effort to their project, actively engage mentors and implement individualized development plans, engage students in research, submit quarterly progress reports, present at regional and/or national meetings, submit the results for publication in peer-reviewed journals, and participate in INBRE-sponsored workshops. Research Training Faculty will build biomedical research capacity by providing additional high-level opportunities for student research and training. For both aims, emphasis will be placed on mentorship (both of faculty and their students and trainees) and evaluation. Successful implementation of the two aims of the Developmental Research Projects Program will be facilitated by regular internal formative evaluations and measured by a final summative evaluation carried out by the PI, PC, EAC, Evaluation Coordinator, an independent evaluation consultant, and an AAAS review panel.

Public Health Relevance

requires advances in biomedical research and an informed, skilled workforce able to leverage the information being produced by high-throughput genomics technology at a rapidly accelerating rate. The Developmental Research Project Program ofthe Maine-INBRE will fill this need both by increasing the excellence of ongoing genomics-oriented biomedical research across the state of Maine, and by expanding opportunities for the high-level training needed to support growth of the relevant workforce.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM103423-14
Application #
8716060
Study Section
Special Emphasis Panel (ZGM1-TWD-3 (IN))
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-04-30
Support Year
14
Fiscal Year
2014
Total Cost
$996,459
Indirect Cost
$202,351
Name
Mount Desert Island Biological Lab
Department
Type
DUNS #
077470003
City
Salsbury Cove
State
ME
Country
United States
Zip Code
04672
Lisse, Thomas S; King, Benjamin L; Rieger, Sandra (2016) Comparative transcriptomic profiling of hydrogen peroxide signaling networks in zebrafish and human keratinocytes: Implications toward conservation, migration and wound healing. Sci Rep 6:20328
Korstanje, Ron; Deutsch, Konstantin; Bolanos-Palmieri, Patricia et al. (2016) Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria. J Am Soc Nephrol 27:3271-3277
Lee, Elaine C; Kim, Heejung; Ditano, Jennifer et al. (2016) Abnormal Osmotic Avoidance Behavior in C. elegans Is Associated with Increased Hypertonic Stress Resistance and Improved Proteostasis. PLoS One 11:e0154156
Shim, Juyoung; Kennedy, Rachel H; Weatherly, Lisa M et al. (2016) Arsenic inhibits mast cell degranulation via suppression of early tyrosine phosphorylation events. J Appl Toxicol :
Wu, Cheng-Wei; Deonarine, Andrew; Przybysz, Aaron et al. (2016) The Skp1 Homologs SKR-1/2 Are Required for the Caenorhabditis elegans SKN-1 Antioxidant/Detoxification Response Independently of p38 MAPK. PLoS Genet 12:e1006361
Soundararajan, Ramani; Stearns, Timothy M; Czachor, Alexander et al. (2016) Global gene profiling of aging lungs in Atp8b1 mutant mice. Aging (Albany NY) 8:2232-2252
Lisse, Thomas S; Middleton, Leah J; Pellegrini, Adriana D et al. (2016) Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A 113:E2189-98
Liao, Jennifer; Seggio, Joseph A; Ahmad, S Tariq (2016) Mutations in the circadian gene period alter behavioral and biochemical responses to ethanol in Drosophila. Behav Brain Res 302:213-9
Rizzo, Francesca; Coffman, James A; Arnone, Maria Ina (2016) An Elk transcription factor is required for Runx-dependent survival signaling in the sea urchin embryo. Dev Biol 416:173-86
Krasniak, Christopher S; Ahmad, S Tariq (2016) The role of CHMP2B(Intron5) in autophagy and frontotemporal dementia. Brain Res :

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