This Louisiana INBRE proposal builds on the success of our current program and seeks to enhance the biomedical research capacity of our primaly undergraduate institutional (PUI) partners through renewed and expanded collaboration with the bio-medical research community within the State. We will support and continue to develop the infrastructural and intellectual network between all PUIs and all of the biomedical research intensive institutions in the state. Five of the PUIs have been chosen as primary PUI institutions for research awards, based on their missions'which fit with the three thematic areas of the INBRE. These themes (Computational and Structural Biology, Molecular Mechanisms of Disease, Therapeutics and Preventive Medicine) reflect the strengths of the research campuses and the strategic plans and visions of our PUI partner campuses and faculty. Faculty of these 5 PUIs compete for pilot and full research projects within the INBRE. Undergraduates, graduate students and faculty from all 4-year PUIs compete and participate in funded research programs during the summer at the research intensive universities. To facilitate our goals we have developed two cores (Bioinformatics, Biostatistics and Computational Biology, and Molecular and Cell Biology) to provide research support, training and access to research infrastructure. Overlaying all of these activities will be the regular metric driven assessment of our progress in developing individual investigators, enhancement of PUI biomedical research capacity, outreach activities, and the effective usage of cores. We have made significant progress, changes and improvements in our approach. Together with the commitment of faculty, the Universities within the State, and the Louisiana Board of Regents match of $1.2 million will clearly meet our goals and that of the national INBRE program.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-7 (01))
Program Officer
Canto, Maria Teresa
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Louisiana State University A&M Col Baton Rouge
Schools of Veterinary Medicine
Baton Rouge
United States
Zip Code
Kanthala, Shanthi; Banappagari, Sashikanth; Gokhale, Ameya et al. (2015) Novel Peptidomimetics for Inhibition of HER2:HER3 Heterodimerization in HER2-Positive Breast Cancer. Chem Biol Drug Des 85:702-14
Qosa, Hisham; Abuasal, Bilal S; Romero, Ignacio A et al. (2014) Differences in amyloid-? clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling. Neuropharmacology 79:668-78
Mahdavian, Elahe; Palyok, Phillip; Adelmund, Steven et al. (2014) Biological activities of fusarochromanone: a potent anti-cancer agent. BMC Res Notes 7:601
Zheng, Shilong; Zhong, Qiu; Mottamal, Madhusoodanan et al. (2014) Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents. J Med Chem 57:3369-81
McFerrin, Harris E; Olson, Scott D; Gutschow, Miriam V et al. (2014) Rapidly self-renewing human multipotent marrow stromal cells (hMSC) express sialyl Lewis X and actively adhere to arterial endothelium in a chick embryo model system. PLoS One 9:e105411
Gissendanner, Chris R; Wiedemeier, Allison M D; Wiedemeier, Paul D et al. (2014) A web-based restriction endonuclease tool for mycobacteriophage cluster prediction. J Basic Microbiol 54:1140-5
Li, Xiao-Lin; Sluijter, Marjolein; Doorduijn, Elien M et al. (2014) Limited density of an antigen presented by RMA-S cells requires B7-1/CD28 signaling to enhance T-cell immunity at the effector phase. PLoS One 9:e108192
Mahdavian, Elahe; Marshall, Monique; Martin, Patrick M et al. (2014) Caspase-dependent signaling underlies glioblastoma cell death in response to the fungal metabolite, fusarochromanone. Int J Mol Med 34:880-5
Chen, Kui; Soto, Israel; Monroe, W Todd et al. (2014) Photothermolysis of lymphatic endothelial cells by gold nanoshell-mediated hyperthermia. J Nanosci Nanotechnol 14:5347-54
Mohamed, Loqman A; Kaddoumi, Amal (2014) Tacrine sinusoidal uptake and biliary excretion in sandwich-cultured primary rat hepatocytes. J Pharm Pharm Sci 17:427-38

Showing the most recent 10 out of 28 publications