Molecular and cell biology provide an essential linkage among important basic fields of biomedical science, such as genetics, developmental biology, structural biology, immunology, neurobiology, and cancer biology. In recent years, the application of molecular biological principles, methods, and advances in next generation sequencing (NGS) to characterize genomes and transcriptomes has greatly improved our understanding of various cellular mechanisms. Newly developed methodologies often require access to state-of-the-art equipment and technical expertise. Centralized core facilities such as the Molecular and Cell Biology Resources Core (MCBRC) that offer specialized equipment and services in molecular and cell biology, immunology, immunopathology, and microscopy are often called on to provide critical support for biomedical research.
The specific aims of the MCBRC are: To support the research efforts and activities of all LBRN investigators by providing advanced molecular cell biology, microscopy, immunology, and pathology services, and access to state-of-the-art equipment, expertise, and resources. To organize, coordinate, and facilitate interactions among Louisiana Biomedical Research Network (LBRN) investigators, mentors, and students. To promote the development and use of new technologies and assays. And to train primarily undergraduate institution (PUI) faculty, staff, and students in advanced molecular and cellular biology technologies. The MCBRC takes advantage of existing highly organized, centralized services and equipment facilities located primarily at the LSU flagship institution in Baton Rouge, effectively uniting these units toward the common goal of supporting biomedical research performed by PUI investigators. The MCBRC will provide technical and logistical support, enabling the ready exchange of information, ideas, technology, and research capabilities among PUI investigators. MCBRC will ensure that PUI researchers have full access to state-of-the-art equipment and modern research techniques and services. The MCBRC will be administered by the Division of Biotechnology and Molecular Medicine (BioMMED) at the LSU School of Veterinary Medicine.

Public Health Relevance

The Molecular and Cell Biology Resources Core (MCBRC) serves as the primary support unit for biomedical research in the Louisiana Biomedical Research Network and is expected to provide the bulk of training and support to PUI investigators, including managing the biweekly Works in Progress sessions. MCBR-supported research provides an essential link between important fields of biomedical sciences such as genetics, developmental biology, immunology, neurobiology, and cancer biology that impact public health.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM103424-14
Application #
8899071
Study Section
Special Emphasis Panel (ZGM1-TWD-0 (IN))
Project Start
Project End
Budget Start
2015-05-01
Budget End
2016-04-30
Support Year
14
Fiscal Year
2015
Total Cost
$151,027
Indirect Cost
$48,759
Name
Louisiana State University A&M Col Baton Rouge
Department
Type
DUNS #
075050765
City
Baton Rouge
State
LA
Country
United States
Zip Code
70803
Wang, Hua; Sui, Ning; Bai, Xue et al. (2018) Emission Recovery and Stability Enhancement of Inorganic Perovskite Quantum Dots. J Phys Chem Lett 9:4166-4173
Zhang, Xiaoyu; Lu, Min; Zhang, Yu et al. (2018) PbS Capped CsPbI3 Nanocrystals for Efficient and Stable Light-Emitting Devices Using p-i-n Structures. ACS Cent Sci 4:1352-1359
Fakhruddin, Selim; Alanazi, Wael A; Alhamami, Hussain N et al. (2018) Hyperglycaemia induced by chronic i.p. and oral glucose loading leads to hypertension through increased Na+ retention in proximal tubule. Exp Physiol 103:236-249
Kaur, Gagandeep; Bagam, Prathyusha; Pinkston, Rakeysha et al. (2018) Cigarette smoke-induced inflammation: NLRP10-mediated mechanisms. Toxicology 398-399:52-67
Al-Horani, Rami A; Afosah, Daniel K (2018) Recent advances in the discovery and development of factor XI/XIa inhibitors. Med Res Rev 38:1974-2023
Singh, Dhirendra P; Kaur, Gagandeep; Bagam, Prathyusha et al. (2018) Membrane microdomains regulate NLRP10- and NLRP12-dependent signalling in A549 cells challenged with cigarette smoke extract. Arch Toxicol 92:1767-1783
Mei, Suyu; Flemington, Erik K; Zhang, Kun (2018) Transferring knowledge of bacterial protein interaction networks to predict pathogen targeted human genes and immune signaling pathways: a case study on M. tuberculosis. BMC Genomics 19:505
Shen, Xinyu; Sun, Chun; Bai, Xue et al. (2018) Efficient and Stable CsPb(Br/I)3@Anthracene Composites for White Light-Emitting Devices. ACS Appl Mater Interfaces 10:16768-16775
Yin, Wenxu; Zhang, Xiaoyu; Bai, Xue et al. (2018) Low-Cost One-Pot Synthesis of WS2 Quantum Dots with Wide Emission Spectrum for Light-Emitting Applications. Chempluschem 83:1052-1056
Zhang, Wensheng; Flemington, Erik K; Zhang, Kun (2018) Driver gene mutations based clustering of tumors: methods and applications. Bioinformatics 34:i404-i411

Showing the most recent 10 out of 104 publications