During the initial award, we generated >$13 million in new grants to investigators and recruits, and published >130 articles or chapters and >135 abstracts or presentations. We devised a new and effective treatment for tinnitus, developed a device as well as a new drug treatment for hyperreflexia and spasticity after spinal cord injury, we developed a cure (elimination of symptoms) for spatial neglect, discovered a novel mechanism for sleep-wake control that will also impact the mechanisms behind anesthesia, and have begun to decrease the death rate among low birth weight babies in the State. However, we need an additional period of support in order to increase our critical mass of investigators, secure PPG and P50 awards, graduate from the program, and become an independent Center for Translational Neuroscience. We propose to 1) strengthen and augment translational neuroscience research through mentoring promising Junior clinician and basic scientists by established, dedicated senior Mentors, 2) expand the research programs of Early career investigators by forming research teams including successful, previously supported investigators and new Junior investigators mentored by multiple established senior investigators, 3) enhance the infrastructure critical for expanding translational neuroscience research by supporting, upgrading and expanding our Core Facilities, 4) increase the critical mass of translational neuroscience researchers at UAMS by recruiting 5 additional junior scientists, 5) maintain our successful Career Development Program for junior investigators and institute a new Leadership Program for established, early career, and junior researchers, who will be required to meet specific performance milestones, and 6) develop a strategy to "graduate" from COBRE support that will ensure the continuity of the CTN. The Research Plan proposed is designed to meet these aims and create a permanent Center for Translational Neuroscience. Given the successes outlined in our Progress Report, and despite dramatic changes in funding availability, we are confident that we will meet our goals in achieving "graduation" from this program. We look forward to continuing to mentor additional promising clinician and basic scientists, and help improve health care for our citizens.
Two blocks to translational research have been identified, lack of translation of basic science discoveries into clinical studies, and from clinical studies into medical practice. We designed the CTN to address blocks to these processes, while mentoring promising scientists to careers in translational research. The CTN is a beacon for translational research in the region, and is having an impact on the health of its constituents.
|Ou, X; Glasier, C M; Ramakrishnaiah, R H et al. (2014) Impaired white matter development in extremely low-birth-weight infants with previous brain hemorrhage. AJNR Am J Neuroradiol 35:1983-9|
|Messias, Erick; Kindrick, Kristi; Castro, Juan (2014) School bullying, cyberbullying, or both: correlates of teen suicidality in the 2011 CDC Youth Risk Behavior Survey. Compr Psychiatry 55:1063-8|
|Constans, Joseph I; Kimbrell, Timothy A; Nanney, John T et al. (2014) Over-reporting bias and the modified Stroop effect in Operation Enduring and Iraqi Freedom veterans with and without PTSD. J Abnorm Psychol 123:81-90|
|Kamarunas, Erin E; McCullough, Gary H; Guidry, Tiffany J et al. (2014) Effects of topical nasal anesthetic on fiberoptic endoscopic examination of swallowing with sensory testing (FEESST). Dysphagia 29:33-43|
|Lairamore, Chad I; Garrison, Mark K; Bourgeon, Laetitia et al. (2014) Effects of functional electrical stimulation on gait recovery post-neurological injury during inpatient rehabilitation. Percept Mot Skills 119:591-608|
|Ou, Xiawei; Glasier, Charles M; Ramakrishnaiah, Raghu H et al. (2014) Diffusion tensor imaging in extremely low birth weight infants managed with hypercapnic vs. normocapnic ventilation. Pediatr Radiol 44:980-6|
|Mulkey, Sarah B; Ou, Xiawei; Ramakrishnaiah, Raghu H et al. (2014) White matter injury in newborns with congenital heart disease: a diffusion tensor imaging study. Pediatr Neurol 51:377-83|
|Hyde, James; MacNicol, Melanie; Odle, Angela et al. (2014) The use of three-dimensional printing to produce in vitro slice chambers. J Neurosci Methods 238:82-7|
|Odle, Angela K; Haney, Anessa; Allensworth-James, Melody et al. (2014) Adipocyte versus pituitary leptin in the regulation of pituitary hormones: somatotropes develop normally in the absence of circulating leptin. Endocrinology 155:4316-28|
|Garcia-Rill, E; Kezunovic, N; D'Onofrio, S et al. (2014) Gamma band activity in the RAS-intracellular mechanisms. Exp Brain Res 232:1509-22|
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