This proposal will continue the goals of the Arkansas IDeA Network for Biomedical Research Excellence (INBRE) to expand biomedical research capacity in Arkansas. Building upon infrastructure developed during the first INBRE phase, three research-intensive, lead institutions in the state?the University of Arkansas for Medical Sciences;the University of Arkansas, Fayetteville, and the University of Arkansas at Little Rock?will provide scientific leadership. Thirteen investigators, faculty from six undergraduate institutions, in collaboration with their mentors at the lead institutions, will conduct research under the overall theme of Cellular Signaling, Growth, and Differentiation. The Administrative Core will coordinate all Arkansas INBRE activities and facilitate the research accomplishments of these 13 investigators. The interactions among undergraduate researchers across the state will be highlighted by an annual conference attended by all INBRE faculty and students. The Arkansas INBRE will continue its commitment to expand opportunities for underrepresented groups. The INBRE will partner with the Center for Diversity Affairs and the School in advancing the goals of the newly NIH-funded Initiative for Maximizing Student Diversity (IMSD) Program to increase the numbers of minority students completing graduate degrees in the biomedical sciences at UAMS. Communication among INBRE participants will be facilitated by Access Grid Studios linked through Internet2. The Bioinformatics Core will be a statewide research and educational resource to give undergraduate faculty and students access to the computational tools needed for multidisciplinary biomedical research. This Core will also host a student exchange with Jackson State University (a Mississippi RCMI) to collaborate In a long-term study of cardiovascular disease in African Americans. The Arkansas INBRE will also support a Science Research Core consisting of proteomics, digital microscopy and DNA damage/toxicology facilities. These will provide investigators access to sophisticated instrumentation and technical expertise difficult to establish at a small institution. The Outreach Core will offer mentored summer research opportunities to non-INBRE undergraduate faculty and students throughout the state. Through further enhancement of research infrastructure, particularly at undergraduate Institutions, the Arkansas INBRE will improve the ability of academic researchers to compete for federal funding, increase the number of undergraduate students who choose careers in biomedical research, and stimulate the growth of biotechnical industries in Arkansas.

Public Health Relevance

The INBRE program allows Arkansas investigators to be more competitive for federal funding of research that leads to better medical diagnosis and development of therapies for human diseases. INBRE support of undergraduate student training in biomedical research contributes to the development of the next generations of U.S. biomedical scientists.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
8P20GM103429-11
Application #
8261896
Study Section
Special Emphasis Panel (ZRR1-RI-7 (01))
Program Officer
Douthard, Regine
Project Start
2001-09-30
Project End
2015-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
11
Fiscal Year
2012
Total Cost
$2,879,139
Indirect Cost
$213,459
Name
University of Arkansas for Medical Sciences
Department
Physiology
Type
Schools of Medicine
DUNS #
122452563
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Stratford Jr, Robert; Vu, Christopher; Sakon, Joshua et al. (2014) Pharmacokinetics in rats of a long-acting human parathyroid hormone-collagen binding domain peptide construct. J Pharm Sci 103:768-75
Kovak, Matthew R; Saraswati, Sarika; Schoen, David J et al. (2014) Investigation of galectin-3 function in the reproductive tract by identification of binding ligands in human seminal plasma. Am J Reprod Immunol 72:403-12
Hill, Brent J F; Muldrew, Edwin (2014) Oestrogen upregulates the sarcoplasmic reticulum Ca(2+) ATPase pump in coronary arteries. Clin Exp Pharmacol Physiol 41:430-6
Xie, Li; Chen, Jing; McMickle, Anthony et al. (2014) The immunomodulator AS101 suppresses production of inflammatory cytokines and ameliorates the pathogenesis of experimental autoimmune encephalomyelitis. J Neuroimmunol 273:31-41
Zhou, Guo-Lei; Zhang, Haitao; Field, Jeffrey (2014) Mammalian CAP (Cyclase-associated protein) in the world of cell migration: Roles in actin filament dynamics and beyond. Cell Adh Migr 8:55-9
Sparks, Kelsey A; Gleason, Nicholas J; Gist, Renetra et al. (2014) Comparisons of interfacial Phe, Tyr, and Trp residues as determinants of orientation and dynamics for GWALP transmembrane peptides. Biochemistry 53:3637-45
Katikaneni, Ranjitha; Ponnapakkam, Tulasi; Matsushita, Osamu et al. (2014) Treatment and prevention of chemotherapy-induced alopecia with PTH-CBD, a collagen-targeted parathyroid hormone analog, in a non-depilated mouse model. Anticancer Drugs 25:30-8
Ng, Hui Wen; Zhang, Wenqian; Shu, Mao et al. (2014) Competitive molecular docking approach for predicting estrogen receptor subtype ? agonists and antagonists. BMC Bioinformatics 15 Suppl 11:S4
Papazyan, Romeo; Voronina, Ekaterina; Chapman, Jessica R et al. (2014) Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis. Elife 3:e02996
Yang, Carrie S; Mercer, Kelly E; Alund, Alexander W et al. (2014) Genistein supplementation increases bone turnover but does not prevent alcohol-induced bone loss in male mice. Exp Biol Med (Maywood) 239:1380-9

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