West Virginia is a State that has had a historically low success rate in obtaining grant awards from the National Institutes of Health and has been designated as an IDeA State. Marshall University (MU), in partnership with West Virginia University (WVU), was awarded an IDeA Network of Biomedical Research Excellence (INBRE) award (WV-INBRE) to help develop biomedical research at WV primarily undergraduate institutions (PUIs) and to enhance the pipeline of students from these PUIs entering the biomedical research field as a career. The current WV-INBRE renewal application will build on the successes of the existing program. To this end, MU, in partnership with WVU, will serve as lead institutions to a research network consisting of eleven undergraduate institutions. The multi-disciplinary research theme for this network will be cellular and molecular biology with an emphasis on cardiovascular disease and cancer. Four PUIs will house five major research projects and two PUIs will have Faculty Research Development Awards (FRDAs) for promising junior investigators. Five additional PUIs have biomedical researchers eligible for FRDAs. Collectively, these schools comprise the heart of the WV research network. Administrative, Bioinformatics and Genomic Cores have been established to facilitate the research progress, mentoring and training, and career development of scientists and students at the partner instutions. The successful community-based participatory research core Appalachian Cardiovascular Research Network (ACoRN) will be expanded. In addition, ties to WV COBREs will be strengthened and interactions with WV's Health Science Technology Academy (HSTA) program will be initiated. Programs are proposed to provide research opportunities for undergraduates students that will help serve as a pipeline for these students into health related research careers. Additional programs and support for PUI biomedical research investigators without major projects will be made available to strengthen their biomedical research potential. In addition, through providing numerous workshops, seminars, research training and mentoring, and access to state-of-the-art core facilities, WV-INBRE will help enhance the science and technology knowledge base of the WV workforce.

Public Health Relevance

WV-INBRE sponsored research projects will investigate several human health issues including cardiovascular disease and cancer. Projects are also proposed that investigate issues related to drug biotransformation and infectious disease. An important thrust of this program is directed toward enhancing the pipeline of undergraduate students choosing a career in the biomedical science research field.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103434-13
Application #
8475490
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Program Officer
Douthard, Regine
Project Start
2001-09-30
Project End
2014-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
13
Fiscal Year
2013
Total Cost
$3,410,339
Indirect Cost
$641,355
Name
Marshall University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
036156615
City
Huntington
State
WV
Country
United States
Zip Code
25701
Han, Alice A; Currie, Holly N; Loos, Matthew S et al. (2017) The impact of cytokine responses in the intra- and extracellular signaling network of a traumatic injury. Cytokine :
Rankin, Gary O; Tyree, Connor; Pope, Deborah et al. (2017) Role of Free Radicals and Biotransformation in Trichloronitrobenzene-Induced Nephrotoxicity In Vitro. Int J Mol Sci 18:
Wright, Kristeena Ray; Mitchell, Brenda; Santanam, Nalini (2017) Redox regulation of microRNAs in endometriosis-associated pain. Redox Biol 12:956-966
Haramizu, Satoshi; Asano, Shinichi; Butler, David C et al. (2017) Dietary resveratrol confers apoptotic resistance to oxidative stress in myoblasts. J Nutr Biochem 50:103-115
Bedenbaugh, Michelle N; O'Connell, Ryan C; Lopez, Justin A et al. (2017) Kisspeptin, GnRH, and ER? colocalise with nNOS neurones in prepubertal female sheep. J Neuroendocrinol :
Peng, Yin; Yan, Shun; Chen, Dongquan et al. (2017) Pdgfrb is a direct regulatory target of TGF? signaling in atrioventricular cushion mesenchymal cells. PLoS One 12:e0175791
Voronkova, Maria A; Luanpitpong, Sudjit; Rojanasakul, Liying Wang et al. (2017) SOX9 Regulates Cancer Stem-Like Properties and Metastatic Potential of Single-Walled Carbon Nanotube-Exposed Cells. Sci Rep 7:11653
Takahashi, Hideyuki; Suzuki, Yutaka; Mohamed, Junaith S et al. (2017) Epigallocatechin-3-gallate increases autophagy signaling in resting and unloaded plantaris muscles but selectively suppresses autophagy protein abundance in reloaded muscles of aged rats. Exp Gerontol 92:56-66
Pinti, Mark V; Hathaway, Quincy A; Hollander, John M (2017) Role of microRNA in metabolic shift during heart failure. Am J Physiol Heart Circ Physiol 312:H33-H45
Li, Bingyun; Webster, Thomas J (2017) Bacteria antibiotic resistance: New challenges and opportunities for implant-associated orthopedic infections. J Orthop Res :

Showing the most recent 10 out of 175 publications