West Virginia is a State that has had a historically low success rate in obtaining grant awards from the National Institutes of Health and has been designated as an IDeA State. Marshall University (MU), in partnership with West Virginia University (WVU), was awarded an IDeA Network of Biomedical Research Excellence (INBRE) award (WV-INBRE) to help develop biomedical research at WV primarily undergraduate institutions (PUIs) and to enhance the pipeline of students from these PUIs entering the biomedical research field as a career. The current WV-INBRE renewal application will build on the successes of the existing program. To this end, MU, in partnership with WVU, will serve as lead institutions to a research network consisting of eleven undergraduate institutions. The multi-disciplinary research theme for this network will be cellular and molecular biology with an emphasis on cardiovascular disease and cancer. Four PUIs will house five major research projects and two PUIs will have Faculty Research Development Awards (FRDAs) for promising junior investigators. Five additional PUIs have biomedical researchers eligible for FRDAs. Collectively, these schools comprise the heart of the WV research network. Administrative, Bioinformatics and Genomic Cores have been established to facilitate the research progress, mentoring and training, and career development of scientists and students at the partner instutions. The successful community-based participatory research core Appalachian Cardiovascular Research Network (ACoRN) will be expanded. In addition, ties to WV COBREs will be strengthened and interactions with WV's Health Science Technology Academy (HSTA) program will be initiated. Programs are proposed to provide research opportunities for undergraduates students that will help serve as a pipeline for these students into health related research careers. Additional programs and support for PUI biomedical research investigators without major projects will be made available to strengthen their biomedical research potential. In addition, through providing numerous workshops, seminars, research training and mentoring, and access to state-of-the-art core facilities, WV-INBRE will help enhance the science and technology knowledge base of the WV workforce.

Public Health Relevance

WV-INBRE sponsored research projects will investigate several human health issues including cardiovascular disease and cancer. Projects are also proposed that investigate issues related to drug biotransformation and infectious disease. An important thrust of this program is directed toward enhancing the pipeline of undergraduate students choosing a career in the biomedical science research field.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
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Special Emphasis Panel (ZRR1-RI-4 (01))
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Douthard, Regine
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Marshall University
Schools of Medicine
United States
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Racine, Christopher; Ward, Dakota; Anestis, Dianne K et al. (2014) 3,4,5-Trichloroaniline nephrotoxicity in vitro: potential role of free radicals and renal biotransformation. Int J Mol Sci 15:20900-12
Magro, Albert; Magro, Alice; Shrestha, Sirish et al. (2014) Metalloproteinase dependent reduction of cell surface cluster determinants upon the induction of apoptosis. Int J Oncol 44:1539-50
Tomblin, Justin K; Salisbury, Travis B (2014) Insulin like growth factor 2 regulation of aryl hydrocarbon receptor in MCF-7 breast cancer cells. Biochem Biophys Res Commun 443:1092-6
Rottgen, Trey S; Fancher, Ibra S; Asano, Shinichi et al. (2014) Bisphenol A activates BK channels through effects on * and *1 subunits. Channels (Austin) 8:249-57
Luanpitpong, Sudjit; Wang, Liying; Stueckle, Todd A et al. (2014) Caveolin-1 regulates lung cancer stem-like cell induction and p53 inactivation in carbon nanotube-driven tumorigenesis. Oncotarget 5:3541-54
Wenger, Sharon L; Hansroth, Joseph; Shackelford, Amy L (2014) Decreased telomere length in metaphase and interphase cells from newborns with trisomy 21. Gene 542:87
de Regt, Anna K; Yin, Yeshi; Withers, T Ryan et al. (2014) Overexpression of CupB5 activates alginate overproduction in Pseudomonas aeruginosa by a novel AlgW-dependent mechanism. Mol Microbiol 93:415-25
Withers, T Ryan; Yin, Yeshi; Yu, Hongwei D (2014) Identification and characterization of a novel inhibitor of alginate overproduction in Pseudomonas aeruginosa. Pathog Dis 70:185-8
Withers, T Ryan; Yin, Yeshi; Yu, Hongwei D (2014) Identification of novel genes associated with alginate production in Pseudomonas aeruginosa using mini-himar1 mariner transposon-mediated mutagenesis. J Vis Exp :
Valentovic, Monica A; Ball, John G; Brown, J Mike et al. (2014) Resveratrol attenuates cisplatin renal cortical cytotoxicity by modifying oxidative stress. Toxicol In Vitro 28:248-57

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