The KBRIN-Centralized Core Facility, otherwise known at the Uofl, as the Uofl GG enomics Core Facility, has been operating as a merged INBRE-COBRE operation since 2008, although certain individual components were available separately from either the INBRE or COBRE awards since 2001. Its objectives are to provide state of the art genomic related technologies, including microarray and deep sequencing services to Uofl researchers as well as to investigators in the KBRIN-affiliated institutions and its outreach institutions across the Commonwealth of Kentucky. Its services are centered around the most advanced and comprehensive platforms of high-density oligonucleotide array technologies offered by Affymetrix, Inc. and Agilent, Inc, as well as the next generation sequencing capabilities of the Jon Torrent PGM platform. These platforms allow standardized analyses of RNA or miRNA expression profiles, splice patterns and variations, DNA mutations, and single nucleotide polymorphism profiles. The Facility ensures that all investigators, including clinical faculty and basic science groups, will be able to adopt such state-of-the-art technologies for their investigative goals using clinical specimen, or animal model or cell culture materials. Since its inception, the Facility has experienced a rapid growth in personnel, user numbers and diversity of experimental platforms, allocated space, attendance in training events, and resources for data analysis and mining. It has been an integral part of several funded and/or currently pending individual and multi-investigator Center and Training grant applications, the strongest case for its longevity and its continued utility. The Facility is currently a key component of COBRE 8P20GM103482-10 Center of Biomedical Research Excellence in Molecular Targets (D. Miller, P.l.), COBRE 8P20GM103453-10 Molecular Determinants of Developmental Defects (R. Greene, P.l.), NIGMS- KY-INBRE P20GM103436, KY-IDeA Networks of Biomedical Research Excellence award (N. Cooper, P.l.), and training grant NIEHS T32 ES11564 Uofl EElnvironmental Health Sciences Training Program (D. Hein, P.l.).

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
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Special Emphasis Panel (ZGM1-TWD-7 (IN))
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University of Louisville
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Ebersole, J L; Kirakodu, S; Novak, M J et al. (2016) Effects of aging in the expression of NOD-like receptors and inflammasome-related genes in oral mucosa. Mol Oral Microbiol 31:18-32
Yates, Justin R; Breitenstein, Kerry A; Gunkel, Benjamin T et al. (2016) Effects of NMDA receptor antagonists on probability discounting depend on the order of probability presentation. Pharmacol Biochem Behav 150-151:31-38
Cieply, Benjamin; Park, Juw Won; Nakauka-Ddamba, Angela et al. (2016) Multiphasic and Dynamic Changes in Alternative Splicing during Induction of Pluripotency Are Coordinated by Numerous RNA-Binding Proteins. Cell Rep 15:247-55
Bowling, Bethany V; Schultheis, Patrick J; Strome, Erin D (2016) Implementation and assessment of a yeast orphan gene research project: involving undergraduates in authentic research experiences and progressing our understanding of uncharacterized open reading frames. Yeast 33:43-53
Monroe, J David; Manning, Dustin P; Uribe, Phillip M et al. (2016) Hearing sensitivity differs between zebrafish lines used in auditory research. Hear Res 341:220-231
Matveeva, Elena; Maiorano, John; Zhang, Qingyang et al. (2016) Involvement of PARP1 in the regulation of alternative splicing. Cell Discov 2:15046
Malloy, Cole A; Ritter, Kyle; Robinson, Jonathan et al. (2016) Pharmacological identification of cholinergic receptor subtypes on Drosophila melanogaster larval heart. J Comp Physiol B 186:45-57
Smith, Michael E (2016) Relationship Between Hair Cell Loss and Hearing Loss in Fishes. Adv Exp Med Biol 875:1067-74
Harris, Jesse A; Carlson, Katy (2016) Keep it local (and final): Remnant preferences in ""let alone"" ellipsis. Q J Exp Psychol (Hove) 69:1278-301
Peveler, Willard W; Sanders, Gabe; Marczinski, Cecile et al. (2016) Effects of energy drinks on economy and cardiovascular measures. J Strength Cond Res :

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