This is a proposal to continue the development of the Nevada IDeA Network of Biomedical Research Excellence (NV INBRE) initiated in 2005. During the first funding period we established an administrative network linking the major research and education institutions in Nevada, we supported researchers at these institutions, and we established and expanded a series of statewide research service cores. In addition, we established and developed a Biomedical Students Pipeline program that mentors under-represented students enrolled in Nevada community colleges . In the following proposal, we describe programs that will continue the development of our multidisciplinary research network. The scientific focus of this development will be """"""""Cell Growth and Differentiation"""""""".
Our Specific Aims are: 1) We will develop the research base and capacity at the host and partner institutions with targeted hires of new researchers and by providing research and mentoring support to faculty, postdoctoral fellows, and graduate students. We are expanding this component of the NV INBRE to include translational and community engagement projects. 2) We will support and develop research service cores in bioinformatics, genomics, proteomics, cytometry, confocal imaging, histology, and live animal imaging that will serve researchers and students at the host, partner, and outreach institutions. 3) We will enhance the INBRE student development pipeline by increasing mentoring and research programs for undergraduate students (adding programs at two new Outreach Institutions), supporting small grants for faculty development at the outreach institutions, and by initiating a program to equip and support science teachers in K-12. 4) We will develop a Clinical Pipeline in collaboration with the UC Davis Clinical and Translational Science Center that will provide training in clinical and translational research for medical students, medical residents, and faculty at the host and partner institutions. 5) We will expand research opportunities across the Western IDeA Region by jointly funding Collaborative Interstate Seed Grants, Undergraduate Student Interstate Research Opportunities, Regional Scientific and Programmatic Meetings, and a Regional Resource Exchange.

Public Health Relevance

The proposed programs will improve public health by developing infrastructure and personnel to support biomedical research and education. We will provide research opportunities to middle school students, undergraduate students, medical students, and university faculty. In addition, we will develop programs to engage underserved communities in biomedical issues and will stimulate the development of translational research in Nevada.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103440-12
Application #
8484410
Study Section
Special Emphasis Panel (ZRR1-RI-7 (01))
Program Officer
Gorospe, Rafael
Project Start
2001-09-01
Project End
2015-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
12
Fiscal Year
2013
Total Cost
$2,649,419
Indirect Cost
$439,078
Name
University of Nevada Reno
Department
Physiology
Type
Schools of Medicine
DUNS #
146515460
City
Reno
State
NV
Country
United States
Zip Code
89557
Blanco, Luz P; Payne, Bryan L; Feyertag, Felix et al. (2018) Proteins of generalist and specialist pathogens differ in their amino acid composition. Life Sci Alliance 1:e201800017
Koirala, Bimal; Lin, Jingjun; Lau, Gee W et al. (2018) Development of a Dominant Negative Competence-Stimulating Peptide (dnCSP) that Attenuates Streptococcus pneumoniae Infectivity in a Mouse Model of Acute Pneumonia. Chembiochem 19:2380-2386
Mull, Ryan W; Harrington, Anthony; Sanchez, Lucia A et al. (2018) Cyclic Peptides that Govern Signal Transduction Pathways: From Prokaryotes to Multi-Cellular Organisms. Curr Top Med Chem 18:625-644
Calfee, Gregory; Danger, Jessica L; Jain, Ira et al. (2018) Identification and Characterization of Serotype-Specific Variation in Group A Streptococcus Pilus Expression. Infect Immun 86:
Zhang, Yunfang; Zhang, Xudong; Shi, Junchao et al. (2018) Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. Nat Cell Biol 20:535-540
Abdul, Ata Ur Rahman Mohammed; De Silva, Bhagya; Gary, Ronald K (2018) The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of ?-catenin, a GSK3 substrate, in human glioblastoma cells. Biol Open 7:
Pinheiro, Paulo S; Callahan, Karen E; Boscoe, Francis P et al. (2018) Cancer Site-Specific Disparities in New York, Including the 1945-1965 Birth Cohort's Impact on Liver Cancer Patterns. Cancer Epidemiol Biomarkers Prev 27:917-927
O'Brien, Kristin M; Rix, Anna S; Egginton, Stuart et al. (2018) Cardiac mitochondrial metabolism may contribute to differences in thermal tolerance of red- and white-blooded Antarctic notothenioid fishes. J Exp Biol 221:
Yang, Yifang; Cornilescu, Gabriel; Tal-Gan, Yftah (2018) Structural Characterization of Competence-Stimulating Peptide Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumoniae. Biochemistry 57:5359-5369
Harrington, Anthony; Tal-Gan, Yftah (2018) Identification of Streptococcus gallolyticus subsp. gallolyticus (Biotype I) Competence-Stimulating Peptide Pheromone. J Bacteriol 200:

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