The development of the core facilities has been a learning experience for the PI of the NO INBRE. The major lesson learned since initial funding of the NO INBRE is that in a low population, large land mass state with a limited investigator base, one must develop core facilities that provide services that cannot be purchased through commercial entities. This certainly applies to flow and cell sorting since there is no other facility capable of sorting cells in the entire state of North Dakota. Likewise, it is very difficult, if not impossible, to perform flow through commercial entities or at academic centers distant from one's home laboratory. This is especially true for the sorting of cells, where in most instances immediate processing and/or culture of the product is necessary. A prime example of this situation is in the cutting-edge technology of stem cells, where research in this area is difficult, if not impossible, without the ability to sort and capture the resulting cells for culture and/or analysis. The NO INBRE has identified this core as essential for the further development of research, teaching and service in NO. Simply stated, at some juncture in their undergraduate career, every undergraduate student destined to enter the graduate student or health professional pipeline should have been exposed to flow and cell sorting. The same is true for graduate students destined for postdoctoral fellowships and medical students progressing to residencies.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
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Special Emphasis Panel (ZGM1-TWD-3 (IN))
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University of North Dakota
Grand Forks
United States
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Shabani, Shkelzen; Schmidt, Bryan; Ghimire, Bikalpa et al. (2018) Depression-like symptoms of withdrawal in a genetic mouse model of binge methamphetamine intake. Genes Brain Behav :e12533
Jondle, Christopher N; Gupta, Kuldeep; Mishra, Bibhuti B et al. (2018) Klebsiella pneumoniae infection of murine neutrophils impairs their efferocytic clearance by modulating cell death machinery. PLoS Pathog 14:e1007338
Basson, Marc D; Wang, Qinggang; Chaturvedi, Lakshmi S et al. (2018) Schlafen 12 Interaction with SerpinB12 and Deubiquitylases Drives Human Enterocyte Differentiation. Cell Physiol Biochem 48:1274-1290
Selya, Arielle S; Thapa, Sunita; Mehta, Gaurav (2018) Earlier smoking after waking and the risk of asthma: a cross-sectional study using NHANES data. BMC Pulm Med 18:102
Sun, Yuyang; Sukumaran, Pramod; Selvaraj, Senthil et al. (2018) TRPM2 Promotes Neurotoxin MPP+/MPTP-Induced Cell Death. Mol Neurobiol 55:409-420
Claw, Katrina G; Anderson, Matthew Z; Begay, Rene L et al. (2018) A framework for enhancing ethical genomic research with Indigenous communities. Nat Commun 9:2957
Quenum Zangbede, Fredice O; Chauhan, Arun; Sharma, Jyotika et al. (2018) Galectin-3 in M2 Macrophages Plays a Protective Role in Resolution of Neuropathology in Brain Parasitic Infection by Regulating Neutrophil Turnover. J Neurosci 38:6737-6750
Chauhan, Arun; Sun, Yuyang; Sukumaran, Pramod et al. (2018) M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry. iScience 8:85-102
Sukumaran, Pramod; Sun, Yuyang; Antonson, Neil et al. (2018) Dopaminergic neurotoxins induce cell death by attenuating NF-?B-mediated regulation of TRPC1 expression and autophagy. FASEB J 32:1640-1652
Hovde, Moriah J; Larson, Garret H; Vaughan, Roxanne A et al. (2018) Model systems for analysis of dopamine transporter function and regulation. Neurochem Int :

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