The development of the core facilities has been a learning experience for the PI of the NO INBRE. The major lesson learned since initial funding of the NO INBRE is that in a low population, large land mass state with a limited investigator base, one must develop core facilities that provide services that cannot be purchased through commercial entities. This certainly applies to flow and cell sorting since there is no other facility capable of sorting cells in the entire state of North Dakota. Likewise, it is very difficult, if not impossible, to perform flow through commercial entities or at academic centers distant from one's home laboratory. This is especially true for the sorting of cells, where in most instances immediate processing and/or culture of the product is necessary. A prime example of this situation is in the cutting-edge technology of stem cells, where research in this area is difficult, if not impossible, without the ability to sort and capture the resulting cells for culture and/or analysis. The NO INBRE has identified this core as essential for the further development of research, teaching and service in NO. Simply stated, at some juncture in their undergraduate career, every undergraduate student destined to enter the graduate student or health professional pipeline should have been exposed to flow and cell sorting. The same is true for graduate students destined for postdoctoral fellowships and medical students progressing to residencies.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM103442-14
Application #
8716112
Study Section
Special Emphasis Panel (ZGM1-TWD-3 (IN))
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-04-30
Support Year
14
Fiscal Year
2014
Total Cost
$86,637
Indirect Cost
$24,083
Name
University of North Dakota
Department
Type
DUNS #
102280781
City
Grand Forks
State
ND
Country
United States
Zip Code
58202
Shabani, Shkelzen; Houlton, Sydney K; Hellmuth, Laura et al. (2016) A Mouse Model for Binge-Level Methamphetamine Use. Front Neurosci 10:493
Sun, Yuyang; Sukumaran, Pramod; Selvaraj, Senthil et al. (2016) TRPM2 Promotes Neurotoxin MPP(+)/MPTP-Induced Cell Death. Mol Neurobiol :
Fu, Q; Olson, P; Rasmussen, D et al. (2016) A short-term transition from a high-fat diet to a normal-fat diet before pregnancy exacerbates female mouse offspring obesity. Int J Obes (Lond) 40:564-72
Connahs, Heidi; Rhen, Turk; Simmons, Rebecca B (2016) Transcriptome analysis of the painted lady butterfly, Vanessa cardui during wing color pattern development. BMC Genomics 17:270
Zhang, Ruowen; Wang, Liping; Garrett, Scott H et al. (2016) Elevated connexin 43 expression in arsenite-and cadmium-transformed human bladder cancer cells, tumor transplants and selected high grade human bladder cancers. Exp Toxicol Pathol 68:479-491
Zhang, Ke K; Xiang, Menglan; Zhou, Lun et al. (2016) Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation. Hum Mol Genet 25:1140-51
Slusser-Nore, Andrea; Larson-Casey, Jennifer L; Zhang, Ruowen et al. (2016) SPARC Expression Is Selectively Suppressed in Tumor Initiating Urospheres Isolated from As+3- and Cd+2-Transformed Human Urothelial Cells (UROtsa) Stably Transfected with SPARC. PLoS One 11:e0147362
Mersereau, Eric J; Boyle, Cody A; Poitra, Shelby et al. (2016) Longitudinal Effects of Embryonic Exposure to Cocaine on Morphology, Cardiovascular Physiology, and Behavior in Zebrafish. Int J Mol Sci 17:
Wallert, Mark A; Hammes, Daniel; Nguyen, Tony et al. (2015) RhoA Kinase (Rock) and p90 Ribosomal S6 Kinase (p90Rsk) phosphorylation of the sodium hydrogen exchanger (NHE1) is required for lysophosphatidic acid-induced transport, cytoskeletal organization and migration. Cell Signal 27:498-509
Slusser, Andrea; Bathula, Chandra S; Sens, Donald A et al. (2015) Cadherin expression, vectorial active transport, and metallothionein isoform 3 mediated EMT/MET responses in cultured primary and immortalized human proximal tubule cells. PLoS One 10:e0120132

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