Through our strong mentoring plan, excellent facility development, and outstanding external advisory panel review, we have achieved remarkable success during the Phase I funding of the only bioengineering COBRE in the nation. Begun with only four projects, our program has expanded to support and mentor 13 junior faculty who have collectively received >$10M in external funding, and published 151 journal articles. Five have also received independent status. Through this COBRE funding, we have recruited three junior and two senior BioE faculty. Clemson has provided cost-share support for pilot projects and a significant expansion of core facilities, most notably a new bioengineering innovation campus (CUBEInC, $16M) with the Greenville Hospital System. CUBEInC, with 29,000 sq. ft. of laboratory and networking space for investigators and clinicians, a surgical skills facility, and a conference center, will serve as the new site for our Phase II COBRE initiative. A new bioengineering building was also opened on the MUSC campus in Charleston in 2012. This new $60M facility represents the growing statewide emphasis on bioengineering and regenerative medicine and houses the labs of five full time Clemson tenure track faculty, one of whom is the target PI in this renewal application. Through Phase I COBRE funding, the Clemson Light Imaging Facility (CLIF) is now in the new Life Sciences building on the Clemson campus under the direction of Dr. Terri Bruce, our core director. We will build on these successes in Phase II. We will expand upon biomaterials-based approach in our tissue engineering studies to a more fundamental analysis of tissue regeneration and formation through our South Carolina Bioengineering Center of Regeneration and Formation of Tissues (SC BioCRAFT). We have selected five new outstanding investigators (3 hired during COBRE Phase I) and provided startup funds to develop their research in Phase II. We have also consolidated and added new areas of core expertise. We propose a unique Bioengineering and Bioimaging (B5) Core and Cell, Tissue, and Molecular Analysis (CTMA) core facilities to support junior faculty in the state. This proposal describes our plan to build an effective scientific collaboration to sustain the SC BioCRAFT beyond P20 funding while strengthening the bioengineering and tissue regeneration scientific community in our state and nationally.
Our specific aims are to 1) expand the critical mass of funded investigators affiliated with the COBRE through mentoring in research career development of five additional outstanding targeted investigators with interests and talents relevant to our theme;2) enhance our core to help our targeted faculty compete successfully for NIH funding and forge collaborations with investigators statewide, including COBRE graduates and non-COBRE researchers with relevant interests and;3) Promote formal recognition of SC BioCRAFT as a designated, sustainable University recognized research center to support the transition from COBRE to long-term competitive support from diverse federal and non-federal sources.

Public Health Relevance

The overarching theme of the Bioengineering Center of Regeneration and Formation of Tissues (SC BioCRAFT) is tissue regeneration, which is highly relevant to NIH's mission of applying fundamental knowledge about the nature and behavior of living systems to enhance health, lengthen life, and reduce illness and disability. As the nation's only bioengineering COBRE center, we are currently supporting projects and cores to find novel methods to restore or regenerate diseased neural, cardiovascular, and bone tissues.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
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Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Canto, Maria Teresa
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Clemson University
Biomedical Engineering
Biomed Engr/Col Engr/Engr Sta
United States
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Yu, Jin; Zhu, Hong; Perry, Stephen et al. (2017) Daily supplementation with GrandFusion® improves memory and learning in aged rats. Aging (Albany NY) 9:1041-1054
Gil, Dmitry; Shuvaev, Sergey; Frank-Kamenetskii, Anastasia et al. (2017) Novel Antibacterial Coating on Orthopedic Wires To Eliminate Pin Tract Infections. Antimicrob Agents Chemother 61:
Ghatak, Shibnath; Markwald, Roger R; Hascall, Vincent C et al. (2017) Transforming growth factor ?1 (TGF?1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts. J Biol Chem 292:10465-10489
Angelé-Martínez, Carlos; Nguyen, Khanh Van T; Ameer, Fathima S et al. (2017) Reactive oxygen species generation by copper(II) oxide nanoparticles determined by DNA damage assays and EPR spectroscopy. Nanotoxicology 11:278-288
Tan, Yu; Richards, Dylan; Coyle, Robert C et al. (2017) Cell number per spheroid and electrical conductivity of nanowires influence the function of silicon nanowired human cardiac spheroids. Acta Biomater 51:495-504
Richards, Dylan; Jia, Jia; Yost, Michael et al. (2017) 3D Bioprinting for Vascularized Tissue Fabrication. Ann Biomed Eng 45:132-147
Ghatak, Shibnath; Hascall, Vincent C; Markwald, Roger R et al. (2017) Transforming growth factor ?1 (TGF?1)-induced CD44V6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis. J Biol Chem 292:10490-10519
Richards, Dylan J; Coyle, Robert C; Tan, Yu et al. (2017) Inspiration from heart development: Biomimetic development of functional human cardiac organoids. Biomaterials 142:112-123
Gwak, So-Jung; Macks, Christian; Bae, Sooneon et al. (2017) Physicochemical stability and transfection efficiency of cationic amphiphilic copolymer/pDNA polyplexes for spinal cord injury repair. Sci Rep 7:11247
Gwak, So-Jung; Macks, Christian; Jeong, Da Un et al. (2017) RhoA knockdown by cationic amphiphilic copolymer/siRhoA polyplexes enhances axonal regeneration in rat spinal cord injury model. Biomaterials 121:155-166

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