The goal of this third Delaware INBRE renewal proposal is to take another major step towards improving health care in the State by extending the ongoing work of the DE-INBRE in building a statewide biomedical research capability. The project will continue to strengthen the research expertise and infrastructure of the DE-INBRE academic and clinical partner institutions - the University of Delaware, Delaware State University, Delaware Technical Community College, Wesley College, Christiana Care Health System and Nemours/A.I. duPont Hospital for Children. In addition to a growing statewide bioinformatics program, three biomedical Research Themes will be pursued through developmental research projects: these programs will focus on cancer, cardiovascular disease and neurosciences. Funds are provided to support junior faculty, postdoctoral and graduate students engaged in mentored research projects within each Research Theme. The Research Themes are supported by a statewide biomedical infrastructure developed under the current INBRE, but with considerably enhanced Bioinformatics and Centralized Instrumentation Cores. An Education and Professional Development Core will provide engaging research opportunities for students from the state's undergraduate institutions and community colleges, thereby developing a pipeline of students pursuing careers in the health care industry and enhancing the biomedical knowledge of the state's workforce.
The Specific Aims of the DE-INBRE-3 proposal are to: (1) Foster a statewide Network to create a strong, sustainable biomedical research capability in Delaware;(2) Develop independent and inter-dependent researchers and institutions that thrive within the Network;(3) Institutionalize DE-INBRE initiatives by transitioning programs into the partner institutions;and (4) Enhance the biomedical science and technology knowledge of the state's workforce. The five DE-INBRE Core Sections described in this proposal - Bioinformatics Core;Developmental Research Project Program;Centralized Research Instrumentation Core;Education and Professional Development Core;and Alterations and Renovations Core - will be supported by an effective Administrative Core. This renewal proposal will provide critical funding to continue building biomedical research infrastructure needed to develop the current programs toward a sustainable research capability in Delaware that will have significant impact on the economy of the state and its institutions and the health o Delaware's citizens.
The Delaware INBRE program focuses on addressing the region's greatest risks to health. Basic and translational research in cancer, heart disease and brain function is supported, and researchers, clinicians and students are trained within a well-integrated network of academic and clinical institutions across the state. The goal is to further strengthen Delaware's health research efforts, create health-related jobs and improve the lives of Delawareans.
|Pathania, Mallika; Wang, Yan; Simirskii, Vladimir N et al. (2016) Î²1-integrin controls cell fate specification in early lens development. Differentiation 92:133-147|
|Boutet, Emmanuel; Lieberherr, Damien; Tognolli, Michael et al. (2016) UniProtKB/Swiss-Prot, the Manually Annotated Section of the UniProt KnowledgeBase: How to Use the Entry View. Methods Mol Biol 1374:23-54|
|Huang, Lei; Liao, Li; Wu, Cathy H (2016) Inference of protein-protein interaction networks from multiple heterogeneous data. EURASIP J Bioinform Syst Biol 2016:8|
|D'Souza, Malcolm J; Kevill, Dennis N (2016) Mechanistic Studies of the Solvolyses of Carbamoyl Chlorides and Related Reactions. Int J Mol Sci 17:|
|Heintz, Keely A; Bregenzer, Michael E; Mantle, Jennifer L et al. (2016) Fabrication of 3D Biomimetic Microfluidic Networks in Hydrogels. Adv Healthc Mater 5:2153-60|
|Wang, Yanping; Li, Jin; Kolon, Thomas F et al. (2016) Genomic copy number variation association study in Caucasian patients with nonsyndromic cryptorchidism. BMC Urol 16:62|
|Koenighofer, M; Hung, C Y; McCauley, J L et al. (2016) Mutations in RIT1 cause Noonan syndrome - additional functional evidence and expanding the clinical phenotype. Clin Genet 89:359-66|
|Kaphingst, K A; Ivanovich, J; Biesecker, B B et al. (2016) Preferences for return of incidental findings from genome sequencing among women diagnosed with breast cancer at a young age. Clin Genet 89:378-84|
|Angelo, James M; Cvetkovic, Aleksandar; Gantier, Rene et al. (2016) Characterization of cross-linked cellulosic ion-exchange adsorbents: 2. Protein sorption and transport. J Chromatogr A 1438:100-12|
|Ravikrishnan, Anitha; Ozdemir, Tugba; Bah, Mohamed et al. (2016) Regulation of Epithelial-to-Mesenchymal Transition Using Biomimetic Fibrous Scaffolds. ACS Appl Mater Interfaces 8:17915-26|
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