The goal of this third Delaware INBRE renewal proposal is to take another major step towards improving health care in the State by extending the ongoing work of the DE-INBRE in building a statewide biomedical research capability. The project will continue to strengthen the research expertise and infrastructure of the DE-INBRE academic and clinical partner institutions - the University of Delaware, Delaware State University, Delaware Technical Community College, Wesley College, Christiana Care Health System and Nemours/A.I. duPont Hospital for Children. In addition to a growing statewide bioinformatics program, three biomedical Research Themes will be pursued through developmental research projects: these programs will focus on cancer, cardiovascular disease and neurosciences. Funds are provided to support junior faculty, postdoctoral and graduate students engaged in mentored research projects within each Research Theme. The Research Themes are supported by a statewide biomedical infrastructure developed under the current INBRE, but with considerably enhanced Bioinformatics and Centralized Instrumentation Cores. An Education and Professional Development Core will provide engaging research opportunities for students from the state's undergraduate institutions and community colleges, thereby developing a pipeline of students pursuing careers in the health care industry and enhancing the biomedical knowledge of the state's workforce.
The Specific Aims of the DE-INBRE-3 proposal are to: (1) Foster a statewide Network to create a strong, sustainable biomedical research capability in Delaware;(2) Develop independent and inter-dependent researchers and institutions that thrive within the Network;(3) Institutionalize DE-INBRE initiatives by transitioning programs into the partner institutions;and (4) Enhance the biomedical science and technology knowledge of the state's workforce. The five DE-INBRE Core Sections described in this proposal - Bioinformatics Core;Developmental Research Project Program;Centralized Research Instrumentation Core;Education and Professional Development Core;and Alterations and Renovations Core - will be supported by an effective Administrative Core. This renewal proposal will provide critical funding to continue building biomedical research infrastructure needed to develop the current programs toward a sustainable research capability in Delaware that will have significant impact on the economy of the state and its institutions and the health o Delaware's citizens.
The Delaware INBRE program focuses on addressing the region's greatest risks to health. Basic and translational research in cancer, heart disease and brain function is supported, and researchers, clinicians and students are trained within a well-integrated network of academic and clinical institutions across the state. The goal is to further strengthen Delaware's health research efforts, create health-related jobs and improve the lives of Delawareans.
|Zaru, Rossana; Magrane, Michele; O'Donovan, Claire et al. (2017) From the research laboratory to the database: the Caenorhabditis elegans kinome in UniProtKB. Biochem J 474:493-515|
|Wright, Regina S; Gerassimakis, Constance; Bygrave, Desirée et al. (2017) Dietary Factors and Cognitive Function in Poor Urban Settings. Curr Nutr Rep 6:32-40|
|Barwe, Sonali P; Quagliano, Anthony; Gopalakrishnapillai, Anilkumar (2017) Eviction from the sanctuary: Development of targeted therapy against cell adhesion molecules in acute lymphoblastic leukemia. Semin Oncol 44:101-112|
|Bloh, Kevin M; Bialk, Pawel A; Gopalakrishnapillai, Anilkumar et al. (2017) CRISPR/Cas9-Directed Reassignment of the GATA1 Initiation Codon in K562 Cells to Recapitulate AML in Down Syndrome. Mol Ther Nucleic Acids 7:288-298|
|Gopalakrishnapillai, Anilkumar; Kolb, E Anders; McCahan, Suzanne M et al. (2017) Epigenetic drug combination induces remission in mouse xenograft models of pediatric acute myeloid leukemia. Leuk Res 58:91-97|
|Chiu, Josephine; Valente, Kristin N; Levy, Nicholas E et al. (2017) Knockout of a difficult-to-remove CHO host cell protein, lipoprotein lipase, for improved polysorbate stability in monoclonal antibody formulations. Biotechnol Bioeng 114:1006-1015|
|Stabley, Deborah L; Holbrook, Jennifer; Harris, Ashlee W et al. (2017) Establishing a reference dataset for the authentication of spinal muscular atrophy cell lines using STR profiling and digital PCR. Neuromuscul Disord 27:439-446|
|Vetter, Nancy S; Kolb, E A; Mills, Christopher C et al. (2017) The Microtubule Network and Cell Death Are Regulated by an miR-34a/Stathmin 1/?III-Tubulin Axis. Mol Cancer Res 15:953-964|
|Robinson, Karyn G; Scott, Rebecca A; Hesek, Anne M et al. (2017) Reduced arterial elasticity due to surgical skeletonization is ameliorated by abluminal PEG hydrogel. Bioeng Transl Med 2:222-232|
|D'Souza, Malcolm J; Roeske, Kristopher P; Neff, Lily S (2017) FREE INVENTORY PLATFORM MANAGES CHEMICAL RISKS, ADDRESSES CHEMICAL ACCOUNTABILITY, AND MEASURES COST-EFFECTIVENESS. Int J Adv Sci Eng Technol 5:25-29|
Showing the most recent 10 out of 274 publications