The NM-INBRE DRPP provides critical support for promising new and early career investigators, and is a determining factor in the direction of their developing research careers. These projects address significant biomedical questions and critical health problems in the areas of Brain and Behavioral Health;Cancer;Cardiovascular and Metabolic Diseases;Child Health;Environmental Health;Infectious Disease and Immunity. The quality of the DRPP science is outstanding, resulting in publications in high impact journals, and pending patents for novel pancratistatin and rigidin analogues with anticancer properties. Efforts to encourage research collaboration have been successful, during the current funding period 23% of the publications have involved collaborations between 2 or more NM-INBRE participants, and this trend is expected to increase in the continuing program. Investigators have been successful in competing for external federal grants, in spite of the difficult funding environment, including recent R01, R21, R03, and R15 awards. The DRPP has made significant impacts on the partner institutions, such as San Juan College, a two-year associate degree-granting institution in the four-corners region with a large Native American student population, where the research activity supported by the NM-INBRE was leveraged to justify a competitive application for an NSF grant to remodel the research space and install a clean room that was funded and now supports research projects. The framework of DRPP projects also serve the primary objective of exposing students to research experiences, and this impact will continue with increased opportunities through an expanded portfolio of projects.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
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Special Emphasis Panel (ZGM1-TWD-3 (IN))
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New Mexico State University Las Cruces
Las Cruces
United States
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Torres, David J; Cannon, Judy L; Ricoy, Ulises M et al. (2016) Self-Contained Statistical Analysis of Gene Sets. PLoS One 11:e0163918
Vaziri-Gohar, Ali; Houston, Kevin D (2016) GPER1-mediated IGFBP-1 induction modulates IGF-1-dependent signaling in tamoxifen-treated breast cancer cells. Mol Cell Endocrinol 422:160-71
Medellin, Derek C; Zhou, Qiong; Scott, Robert et al. (2016) Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities. J Med Chem 59:480-5
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Huang, Shijie; Zhu, Xuechen; Melançon 3rd, Charles E (2016) Detection and Quantification of Ribosome Inhibition by Aminoglycoside Antibiotics in Living Bacteria Using an Orthogonal Ribosome-Controlled Fluorescent Reporter. ACS Chem Biol 11:31-7
Wang, Qiang; Waterhouse, Nicklas; Feyijinmi, Olusegun et al. (2016) Development and Application of a High Throughput Protein Unfolding Kinetic Assay. PLoS One 11:e0146232
Rossi, Shannan L; Tesh, Robert B; Azar, Sasha R et al. (2016) Characterization of a Novel Murine Model to Study Zika Virus. Am J Trop Med Hyg 94:1362-9

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