The NM-INBRE DRPP provides critical support for promising new and early career investigators, and is a determining factor in the direction of their developing research careers. These projects address significant biomedical questions and critical health problems in the areas of Brain and Behavioral Health;Cancer;Cardiovascular and Metabolic Diseases;Child Health;Environmental Health;Infectious Disease and Immunity. The quality of the DRPP science is outstanding, resulting in publications in high impact journals, and pending patents for novel pancratistatin and rigidin analogues with anticancer properties. Efforts to encourage research collaboration have been successful, during the current funding period 23% of the publications have involved collaborations between 2 or more NM-INBRE participants, and this trend is expected to increase in the continuing program. Investigators have been successful in competing for external federal grants, in spite of the difficult funding environment, including recent R01, R21, R03, and R15 awards. The DRPP has made significant impacts on the partner institutions, such as San Juan College, a two-year associate degree-granting institution in the four-corners region with a large Native American student population, where the research activity supported by the NM-INBRE was leveraged to justify a competitive application for an NSF grant to remodel the research space and install a clean room that was funded and now supports research projects. The framework of DRPP projects also serve the primary objective of exposing students to research experiences, and this impact will continue with increased opportunities through an expanded portfolio of projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM103451-14
Application #
8716088
Study Section
Special Emphasis Panel (ZGM1-TWD-3 (IN))
Project Start
Project End
Budget Start
2014-06-15
Budget End
2015-03-31
Support Year
14
Fiscal Year
2014
Total Cost
$1,999,007
Indirect Cost
$80,500
Name
New Mexico State University Las Cruces
Department
Type
DUNS #
173851965
City
Las Cruces
State
NM
Country
United States
Zip Code
88003
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Vaziri-Gohar, Ali; Houston, Kevin D (2016) GPER1-mediated IGFBP-1 induction modulates IGF-1-dependent signaling in tamoxifen-treated breast cancer cells. Mol Cell Endocrinol 422:160-71
Medellin, Derek C; Zhou, Qiong; Scott, Robert et al. (2016) Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities. J Med Chem 59:480-5
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Wang, Qiang; Waterhouse, Nicklas; Feyijinmi, Olusegun et al. (2016) Development and Application of a High Throughput Protein Unfolding Kinetic Assay. PLoS One 11:e0146232
Rossi, Shannan L; Tesh, Robert B; Azar, Sasha R et al. (2016) Characterization of a Novel Murine Model to Study Zika Virus. Am J Trop Med Hyg 94:1362-9

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