The NM-INBRE DRPP provides critical support for promising new and early career investigators, and is a determining factor in the direction of their developing research careers. These projects address significant biomedical questions and critical health problems in the areas of Brain and Behavioral Health; Cancer; Cardiovascular and Metabolic Diseases; Child Health; Environmental Health; Infectious Disease and Immunity. The quality of the DRPP science is outstanding, resulting in publications in high impact journals, and pending patents for novel pancratistatin and rigidin analogues with anticancer properties. Efforts to encourage research collaboration have been successful, during the current funding period 23% of the publications have involved collaborations between 2 or more NM-INBRE participants, and this trend is expected to increase in the continuing program. Investigators have been successful in competing for external federal grants, in spite of the difficult funding environment, including recent R01, R21, R03, and R15 awards. The DRPP has made significant impacts on the partner institutions, such as San Juan College, a two-year associate degree-granting institution in the four-corners region with a large Native American student population, where the research activity supported by the NM-INBRE was leveraged to justify a competitive application for an NSF grant to remodel the research space and install a clean room that was funded and now supports research projects. The framework of DRPP projects also serve the primary objective of exposing students to research experiences, and this impact will continue with increased opportunities through an expanded portfolio of projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103451-17
Application #
9249600
Study Section
Special Emphasis Panel (ZGM1-TWD-3)
Project Start
2017-04-01
Project End
2019-03-31
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
17
Fiscal Year
2017
Total Cost
$1,882,094
Indirect Cost
$88,320
Name
New Mexico State University Las Cruces
Department
Type
Domestic Higher Education
DUNS #
173851965
City
Las Cruces
State
NM
Country
United States
Zip Code
88003
Zhong, Hua; Song, Mingzhou (2018) A fast exact functional test for directional association and cancer biology applications. IEEE/ACM Trans Comput Biol Bioinform :
Nemunaitis, Jacklyn M; Brown-Glabeman, Ursa; Soares, Heloisa et al. (2018) Gallbladder cancer: review of a rare orphan gastrointestinal cancer with a focus on populations of New Mexico. BMC Cancer 18:665
Sheng, Haiqing; Duan, Mingrui; Hunter, Samuel S et al. (2018) High-Quality Complete Genome Sequences of Three Bovine Shiga Toxin-ProducingEscherichia coliO177:H- (fliCH25) Isolates Harboring Virulentstx2and Multiple Plasmids. Genome Announc 6:
Dominguez, Matthew J; Lantz, Benjamin J; Rhode, Rebecca J et al. (2018) A multi-column plate adapter provides an economical and versatile high-throughput protein purification system. Protein Expr Purif 152:84-91
DeVore, Stanley B; Young, Coleman H; Li, Guangyuan et al. (2018) Histone citrullination represses miRNA expression resulting in increased oncogene mRNAs in somatolactotrope cells. Mol Cell Biol :
Licon-Munoz, Yamhilette; Fordyce, Colleen A; Hayek, Summer Raines et al. (2018) V-ATPase-dependent repression of androgen receptor in prostate cancer cells. Oncotarget 9:28921-28934
Gautam, Gayatri P; Gurung, Rubi; Fencl, Frank A et al. (2018) Separation of sub-micron particles from micron particles using acoustic fluid relocation combined with acoustophoresis. Anal Bioanal Chem 410:6561-6571
Brown, Tom; Brown, Nick; Stollar, Elliott J (2018) Most yeast SH3 domains bind peptide targets with high intrinsic specificity. PLoS One 13:e0193128
Joseph, Braveen B; Blouin, Nicolas A; Fay, David S (2018) Use of a Sibling Subtraction Method for Identifying Causal Mutations in Caenorhabditis elegans by Whole-Genome Sequencing. G3 (Bethesda) 8:669-678
He, Jingxuan; Melançon 3rd, Charles E (2018) Genetic Incorporation of Unnatural Amino Acids into Proteins of Interest in Streptomyces venezuelae ATCC 15439. Methods Mol Biol 1728:155-168

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