Building on the critical mass of expertise and infrastructure assembled during our first funding period, this proposal seeks five more years of support through NCRR's COBRE program to enable us to further strengthen and consolidate a self-sustaining and flourishing Center for Evolutionary and Theoretical Immunology (CETI). Once again, both junior and senior faculty scholars from the Biology and Computer Science Departments at the University of New Mexico and the Los Alamos National Labs will undertake research projects that seek to reveal basic design principles of immune systems, that model the interactions between pathogens and immune systems, and that explore the evolution of immune responses across animal phyla. Consequently, we will better understand how invertebrate vectors transmit infectious diseases, how pathogens defend themselves from immune attack and how the comparative study of immune systems can lead to exciting new conceptual frameworks and paradigms. We will also improve our mentoring program to develop independently-funded junior investigators, provide our members logistical support in grant preparation and management and at every opportunity strive to improve their long-term career prospects. We will hire additional CETI-related tenure track faculty and continue to partner with other NCRR-programs and the UNM administration to support and improve CETI's core facilities in molecular biology, controlled environments and mass spectrometry/proteomics. We will also expand and improve the physical home of CETI by moving into new facilities that CETI has leveraged through productive partnerships with the UNM administration, and we will initiate a new seed grant program to increase the breadth and impact of CETI. We will develop multi-investigator proposals to mark CETI's graduation from NCRR funding and continue to seek new ways to promote integration and collaborations among our members and with the New Mexico research community. Lastly, CETI will increasingly serve as a catalyst to develop new training and biomedical research opportunities in our state and will use our critical mass to undertake initiatives and favor research enabling us to achieve world class recognition and prominence.

Public Health Relevance

Research conducted by investigators at the Center for Evolutionary and Theoretical Immunology will increase our understanding of the transmission of human parasitic diseases and may lead to the development of new therapeutics. In addition, models of viral diseases will be developed that will improve our ability to predict the spread of epidemics as well as evaluate effectiveness of different treatment regimes.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Liu, Yanping
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of New Mexico
Schools of Arts and Sciences
United States
Zip Code
Dahari, Harel; Shteingart, Shimon; Gafanovich, Inna et al. (2015) Sustained virological response with intravenous silibinin: individualized IFN-free therapy via real-time modelling of HCV kinetics. Liver Int 35:289-94
Canini, Laetitia; DebRoy, Swati; MariƱo, Zoe et al. (2015) Severity of liver disease affects HCV kinetics in patients treated with intravenous silibinin monotherapy. Antivir Ther 20:149-55
Canini, Laetitia; Chatterjee, Anushree; Guedj, Jeremie et al. (2015) A pharmacokinetic/viral kinetic model to evaluate the treatment effectiveness of danoprevir against chronic HCV. Antivir Ther 20:469-77
Osborne, Megan J; Perkin, Joshuah S; Gido, Keith B et al. (2014) Comparative riverscape genetics reveals reservoirs of genetic diversity for conservation and restoration of Great Plains fishes. Mol Ecol 23:5663-79
Zhang, Tianyi; Tacchi, Luca; Wei, Zhiguo et al. (2014) Intraclass diversification of immunoglobulin heavy chain genes in the African lungfish. Immunogenetics 66:335-51
Guedj, Jeremie; Rotman, Yaron; Cotler, Scott J et al. (2014) Understanding early serum hepatitis D virus and hepatitis B surface antigen kinetics during pegylated interferon-alpha therapy via mathematical modeling. Hepatology 60:1902-10
Dahari, Harel; Cotler, Scott J (2014) Individualized treatment for patients with low HCV load (genotype 1): a viral kinetic approach. Hepatology 59:2422-3
Krabbenhoft, Trevor J; Turner, Thomas F (2014) Clock gene evolution: seasonal timing, phylogenetic signal, or functional constraint? J Hered 105:407-15
Musharrafieh, Rami; Tacchi, Luca; Trujeque, Joshua et al. (2014) Staphylococcus warneri, a resident skin commensal of rainbow trout (Oncorhynchus mykiss) with pathobiont characteristics. Vet Microbiol 169:80-8
Graw, Frederik; Balagopal, Ashwin; Kandathil, Abraham J et al. (2014) Inferring viral dynamics in chronically HCV infected patients from the spatial distribution of infected hepatocytes. PLoS Comput Biol 10:e1003934

Showing the most recent 10 out of 33 publications