Building on the critical mass of expertise and infrastructure assembled during our first funding period, this proposal seeks five more years of support through NCRR's COBRE program to enable us to further strengthen and consolidate a self-sustaining and flourishing Center for Evolutionary and Theoretical Immunology (CETI). Once again, both junior and senior faculty scholars from the Biology and Computer Science Departments at the University of New Mexico and the Los Alamos National Labs will undertake research projects that seek to reveal basic design principles of immune systems, that model the interactions between pathogens and immune systems, and that explore the evolution of immune responses across animal phyla. Consequently, we will better understand how invertebrate vectors transmit infectious diseases, how pathogens defend themselves from immune attack and how the comparative study of immune systems can lead to exciting new conceptual frameworks and paradigms. We will also improve our mentoring program to develop independently-funded junior investigators, provide our members logistical support in grant preparation and management and at every opportunity strive to improve their long-term career prospects. We will hire additional CETI-related tenure track faculty and continue to partner with other NCRR-programs and the UNM administration to support and improve CETI's core facilities in molecular biology, controlled environments and mass spectrometry/proteomics. We will also expand and improve the physical home of CETI by moving into new facilities that CETI has leveraged through productive partnerships with the UNM administration, and we will initiate a new seed grant program to increase the breadth and impact of CETI. We will develop multi-investigator proposals to mark CETI's graduation from NCRR funding and continue to seek new ways to promote integration and collaborations among our members and with the New Mexico research community. Lastly, CETI will increasingly serve as a catalyst to develop new training and biomedical research opportunities in our state and will use our critical mass to undertake initiatives and favor research enabling us to achieve world class recognition and prominence.
Research conducted by investigators at the Center for Evolutionary and Theoretical Immunology will increase our understanding of the transmission of human parasitic diseases and may lead to the development of new therapeutics. In addition, models of viral diseases will be developed that will improve our ability to predict the spread of epidemics as well as evaluate effectiveness of different treatment regimes.
|Chechenova, Maria B; Maes, Sara; Oas, Sandy T et al. (2017) Functional redundancy and nonredundancy between two Troponin C isoforms in Drosophila adult muscles. Mol Biol Cell 28:760-770|
|Mrass, Paulus; Oruganti, Sreenivasa Rao; Fricke, G Matthew et al. (2017) ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs. Nat Commun 8:1010|
|Kelly, Cecelia; Takizawa, Fumio; Sunyer, J Oriol et al. (2017) Rainbow trout (Oncorhynchus mykiss) secretory component binds to commensal bacteria and pathogens. Sci Rep 7:41753|
|Lovato, TyAnna L; Cripps, Richard M (2017) High Heart: A Role for Calcineurin Signaling in Hypoxia-Influenced Cardiac Growth. Circ Cardiovasc Genet 10:|
|Malespin, Miguel; Benyashvili, Tamara; Uprichard, Susan L et al. (2017) Prevalence of end of treatment RNA-positive/sustained viral response in HCV patients treated with sofosbuvir combination therapies. Therap Adv Gastroenterol 10:68-73|
|Sepahi, Ali; Tacchi, Luca; Casadei, Elisa et al. (2017) CK12a, a CCL19-like Chemokine That Orchestrates both Nasal and Systemic Antiviral Immune Responses in Rainbow Trout. J Immunol 199:3900-3913|
|Dahari, Harel; Canini, Laetitia; Graw, Frederik et al. (2016) HCV kinetic and modeling analyses indicate similar time to cure among sofosbuvir combination regimens with daclatasvir, simeprevir or ledipasvir. J Hepatol 64:1232-9|
|Adame, Vanesa; Chapapas, Holly; Cisneros, Marilyn et al. (2016) An undergraduate laboratory class using CRISPR/Cas9 technology to mutate drosophila genes. Biochem Mol Biol Educ 44:263-75|
|Sepahi, Ali; Casadei, Elisa; Tacchi, Luca et al. (2016) Tissue Microenvironments in the Nasal Epithelium of Rainbow Trout (Oncorhynchus mykiss) Define Two Distinct CD8?+ Cell Populations and Establish Regional Immunity. J Immunol 197:4453-4463|
|DebRoy, S; Hiraga, N; Imamura, M et al. (2016) Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy. J Viral Hepat 23:708-17|
Showing the most recent 10 out of 85 publications