The present application represents a resubmission (01A1) of a COBRE application wherein we have addressed all concerns noted by reviewers (see "Introduction"). Revised individual project proposals are each preceded by an "Introduction" in which COBRE Investigators respond to Project Critiques provided by reviewers. The primary purpose of this renewal application continues to be fostering of health-related research and mentoring-enhanced competitiveness of junior, unfunded investigators. In this renewal application we have included proposals from: 2 junior investigators who have not previously been a PI on a funded research project grant or program project grant;2 early career investigators who were COBRE supported during our initial funding period, and who were successful in obtaining independent funding from the NIH (R01 and K02);a senior investigator whose proposal will facilitate a mid-career research transition;and a pilot project from a clinical junior investigator seeking to redefine his academic career as a clinical research scientist. Two (2) new faculty lines, representing sustained commitment from the university, have been pledged as part of this competitive renewal application. Two junior faculty who complement the thematic scope of our COBRE will thus be recruited and will be COBRE-supported. Each of these investigators will be mentored by an established, well-funded senior biomedical research scientist recognized for his/her scientific expertise in the area of the COBRE investigator's research proposal. The program continues to be led by Robert M. Greene, Ph.D., an established biomedical research scientist, well recognized for his extensive expertise central to the research theme of the proposal?molecular mechanisms underlying developmental defects. This renewal application, if funded, will 1) substantially enhance the research career development and research competitiveness of no less than five (5) junior investigators, two early career investigators, and one senior investigator, and 2) promote the development and enhance the evolution of our Center such that it will be able to successfully compete for independent Center and/or program project funding. A detailed plan for each COBRE investigator's research career development has been formulated;expectations and objectives for achieving independent funding are clearly articulated;clear and tangible evidence of continuing and expanded institutional commitment is documented;excellent research resources and a supportive intellectual environment exists.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Douthard, Regine
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Louisville
Schools of Dentistry
United States
Zip Code
Neal, Rachel E; Chen, Jing; Jagadapillai, Rekha et al. (2014) Developmental cigarette smoke exposure: hippocampus proteome and metabolome profiles in low birth weight pups. Toxicology 317:40-9
Yang, Dake; Parrish, Rudolph S; Brock, Guy N (2014) Empirical evaluation of consistency and accuracy of methods to detect differentially expressed genes based on microarray data. Comput Biol Med 46:1-10
Jin, Jiu-Zhen; Warner, Dennis R; Lu, Qingxian et al. (2014) Deciphering TGF-?3 function in medial edge epithelium specification and fusion during mouse secondary palate development. Dev Dyn 243:1536-43
Canales, Lorena; Gambrell, Caitlin; Chen, Jing et al. (2013) Prenatal alcohol exposure alters the cerebral cortex proteome in weanling rats. Reprod Toxicol 39:69-75
Gao, Zhongwen; Zhu, Qingsan; Zhang, Yiping et al. (2013) Reciprocal modulation between microglia and astrocyte in reactive gliosis following the CNS injury. Mol Neurobiol 48:690-701
Liu, Yongqing; Mukhopadhyay, Partha; Pisano, M Michele et al. (2013) Repression of Zeb1 and hypoxia cause sequential mesenchymal-to-epithelial transition and induction of aid, Oct4, and Dnmt1, leading to immortalization and multipotential reprogramming of fibroblasts in spheres. Stem Cells 31:1350-62
Liu, Yongqing; Sanchez-Tillo, Ester; Lu, Xiaoqin et al. (2013) Rb1 family mutation is sufficient for sarcoma initiation. Nat Commun 4:2650
Mukhopadhyay, Partha; Rezzoug, Francine; Kaikaus, Jahanzeb et al. (2013) Alcohol modulates expression of DNA methyltranferases and methyl CpG-/CpG domain-binding proteins in murine embryonic fibroblasts. Reprod Toxicol 37:40-8
Liu, Yongqing; Sanchez-Tillo, Ester; Lu, Xiaoqin et al. (2013) Sequential inductions of the ZEB1 transcription factor caused by mutation of Rb and then Ras proteins are required for tumor initiation and progression. J Biol Chem 288:11572-80
Jin, Jiu-Zhen; Ding, Jixiang (2013) Cripto is required for mesoderm and endoderm cell allocation during mouse gastrulation. Dev Biol 381:170-8

Showing the most recent 10 out of 11 publications