The Center for Pediatric Research (CPR) was organized by networking a motivated group of scientists and physicians dedicated to the development and expansion of translational pediatric research. Common barriers that impede translational research were eliminated by integrating researchers from a number major disciplines in pediatric research, enabling a focus on mentored research training for physician and scientists to be maintained. This team approach to solving clinical research questions has transformed the research and clinical programs at Nemours. Our goal over the next five years is to establish the CPR as a sustainable center that drives translational research at Nemours. Building upon our existing strengths in genetics and neuroscience, we have selected four new investigators for support whose research programs fit Within the expertise of our faculty mentors.. This narrower focus will enable the CPR to establish a critical mass of investigators with overlapping research interests to attract funding and recruit new investigators needed to create a sustainable research center. A priority goal in the next cycle will be attracting additional senior faculty to the CPR to strengthen and expand our the core intellectual infrastructure. The center will be established further by integration into a state-wide network of research centers with a focus on translational research.
The aims of this proposal are: 1) To provide the infrastructure to train basic and physician scientists in their quest to become investigators who can procure independent funding for their respective programs;2) To facilitate the development of a multidisciplinary network of physicians and scientists to collaborate on basic and applied research on pediatric disorders;3) To develop translational research programs within the NCRR network in the Delaware Valley to enrich the interface between clinical and basic research. The uniqueness of the CPR is that it has been developed specifically to provide a multidisciplinary training program for pediatric research. The long-term goal is to establish the CPR as the key infrastructural center that acts as a catalyst to develop all research programs at Nemours that are dedicated to translating research discoveries into new therapies for the benefit of children in Delaware.
The CPR is uniquely poised to drive the growth of translational research programs focused on pediatric diseases. The CPR's goals over the next five years are to expand faculty development programs and the reaches of the CPR within the institution and the state. These activities will increase the number of NIH-funded research programs and significantly impact translational research activities in Delaware.
|Butchbach, Matthew E R (2016) Copy Number Variations in the Survival Motor Neuron Genes: Implications for Spinal Muscular Atrophy and Other Neurodegenerative Diseases. Front Mol Biosci 3:7|
|Wang, Yanping; Li, Jin; Kolon, Thomas F et al. (2016) Genomic copy number variation association study in Caucasian patients with nonsyndromic cryptorchidism. BMC Urol 16:62|
|Koenighofer, M; Hung, C Y; McCauley, J L et al. (2016) Mutations in RIT1 cause Noonan syndrome - additional functional evidence and expanding the clinical phenotype. Clin Genet 89:359-66|
|Kecskemethy, Heidi H; Kubaski, Francyne; Harcke, H T et al. (2016) Bone mineral density in MPS IV A (Morquio syndrome type A). Mol Genet Metab 117:144-9|
|Rossi, Sharyn L; Lumpkin, Casey J; Harris, Ashlee W et al. (2016) Identification of early gene expression changes in primary cultured neurons treated with topoisomerase I poisons. Biochem Biophys Res Commun 479:319-324|
|Gopalakrishnapillai, Anilkumar; Kolb, E Anders; Dhanan, Priyanka et al. (2016) Generation of Pediatric Leukemia Xenograft Models in NSG-B2m Mice: Comparison with NOD/SCID Mice. Front Oncol 6:162|
|Butchbach, Matthew E R; Lumpkin, Casey J; Harris, Ashlee W et al. (2016) Protective effects of butyrate-based compounds on a mouse model for spinal muscular atrophy. Exp Neurol 279:13-26|
|Yasuda, Eriko; Suzuki, Yasuyuki; Shimada, Tsutomu et al. (2016) Activity of daily living for Morquio A syndrome. Mol Genet Metab 118:111-22|
|Soori, Mehrnoosh; Lu, Guizhen; Mason, Robert W (2016) Cathepsin Inhibition Prevents Autophagic Protein Turnover and Downregulates Insulin Growth Factor-1 Receptor-Mediated Signaling in Neuroblastoma. J Pharmacol Exp Ther 356:375-86|
|Robbins, Katherine M; Stabley, Deborah L; Holbrook, Jennifer et al. (2016) Paternal uniparental disomy with segmental loss of heterozygosity of chromosome 11 are hallmark characteristics of syndromic and sporadic embryonal rhabdomyosarcoma. Am J Med Genet A 170:3197-3206|
Showing the most recent 10 out of 117 publications