The Hawaii State Research &Education Partnership (HISREP) consists of a network of 10 Universities and community colleges encompassing nearly all of the institutions of higher learning in the State of Hawaii. As in past cycles, HISREP will continue to expand biomedical research capacity by providing resources to a wide spectrum of promising undergraduate students, graduate students, post-docs and junior faculty members residing at partner institutions. HISREP will spark the imagination and inspire the interest of students at all stages of development to pursue careers in biomedical research with a robust portfolio of hands-on-laboratory research, and a diverse menu of education and training sessions. Through a well-crafted Research Development Activity (RDA), HISREP will support a cadre of promising junior faculty members at the PUI's to conduct research projects with a thematic focus of either "Natural Products or Health Disparities", with the goal of formulating competitive research applications to secure extramural funding on a path to research independence. A Bioinformatics Core will provide an expanded menu of bioinformatics, informatics, biostatistical, and computational tools, assistance and advice, as well as training and education activities for HISREP investigators and students alike. An established spirit of cooperation has evolved over time among HISREP partners to increase collaborative research opportunities and share resources. Moreover, students at all stages of development benefiting from HISREP will be encouraged to assume key roles in the future by participating in HISREP training and education activities, and offering research laboratory rotations and mentoring to the next generation of HISREP student, thus creating a self-perpetuating cycle of research career development. Finally, HISREP will be led by a responsible and experienced administration team with support from a Steering Committee as well as expertise and oversight from an External Advisory Committee. Significant support to the UH Hilo College of Pharmacy will be provided to share administrative responsibilities as they mature and expand into an independent administrative campus. Overall, HISREP has matured into a well-developed alliance of partners participating in a broad range of research opportunities to expand research capacity in the state of Hawaii.

Public Health Relevance

HISREP will continue to provide an impressive portfolio of education and biomedical research opportunities for the state of Hawaii in order to expand the biomedical research capacity, expertise, and human resources of the network partners, which includes nearly every institution of higher learning in the state, from community college through the state's Primarily Undergraduate Institutions. Taken together, HISREP will strengthen Hawaii as a Pacific hub for biomedical research and contribute significantly to the state's current and future need for well trained and skilled biomedical scientists, and a workforce to power its burgeoning biotechnology industry.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM103466-12
Application #
8531387
Study Section
Special Emphasis Panel (ZGM1-TWD-A (IN))
Program Officer
Gorospe, Rafael
Project Start
2001-09-30
Project End
2018-04-30
Budget Start
2013-08-01
Budget End
2014-04-30
Support Year
12
Fiscal Year
2013
Total Cost
$3,945,653
Indirect Cost
$927,180
Name
University of Hawaii
Department
None
Type
Schools of Medicine
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Sentell, Tetine; Chang, Ann; Cheng, Yongjun et al. (2014) Maternal quality and safety outcomes for Asians and Pacific Islanders in Hawai'i: an observational study from five years of statewide data. BMC Pregnancy Childbirth 14:298
Tsutsumi, Lissa S; Owusu, Yaw B; Hurdle, Julian G et al. (2014) Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review. Curr Top Med Chem 14:152-75
Chan, Yvonne L; Schanzenbach, David; Hickerson, Michael J (2014) Detecting concerted demographic response across community assemblages using hierarchical approximate Bayesian computation. Mol Biol Evol 31:2501-15
Ching, Travers H; Yoza, Brandon A; Li, Qing X (2014) Quartet analysis of putative horizontal gene transfer in Crenarchaeota. J Mol Evol 78:163-70
Park, Eun-Jung; Shen, Li; Sun, Dianqing et al. (2014) Inhibitory effect of a callophycin A derivative on iNOS expression via inhibition of Akt in lipopolysaccharide-stimulated RAW 264.7 cells. J Nat Prod 77:527-35
Umemoto, Eric Y; Speck, Mark; Shimoda, Lori M N et al. (2014) Single-walled carbon nanotube exposure induces membrane rearrangement and suppression of receptor-mediated signalling pathways in model mast cells. Toxicol Lett 229:198-209
Feng, Li; Maddox, Marcus M; Alam, Md Zahidul et al. (2014) Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives. J Med Chem 57:8398-420
Greineisen, William E; Speck, Mark; Shimoda, Lori M N et al. (2014) Lipid body accumulation alters calcium signaling dynamics in immune cells. Cell Calcium 56:169-80
Samarasinghe, Buddhini; Wales, Christina T K; Taylor, Frederick R et al. (2014) Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux. Biochem Pharmacol 87:445-55
Wu, X; Alam, M Z; Feng, L et al. (2014) Prospects for flavonoid and related phytochemicals as nature-inspired treatments for Clostridium difficile infection. J Appl Microbiol 116:23-31

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