Schizophrenia (SZ) and bipolar disorder (BP) are two of the most challenging and costliest mental disorders in terms of human suffering and societal expenditure. Clinically, SZ and BP can present with similar symptomology during acute psychotic periods, raising issues of differential diagnosis, frontline medication regime, and treatment planning. Currently there are no definitive biological markers for either diseases, and their diagnosis relies upon longitudinal symptom assessment. Several studies have been published which compared SZ and BP within a single modality such as fMRI, sMRI, EEG, and DTI, and have identified brain alterations that discriminate the two conditions. However, this work has been hampered by small sample sizes, limited re-test reliability and general replicability. Each brain imaging technique provides a different view of brain function or structure, while multimodal fusion capitalizes on the strength of each and may uncover the hidden factors that can unify disparate findings. Here we seek to replicate and extend the search for biomarkers to reliably differentiate SZ from BP by using N-way multimodal fusion, e.g., fMRI, DTI, and sMRI data, which is expected to improve the group-differentiating ability beyond any single modality. We will develop a novel multivariate model and release a user-friendly toolbox, which enables people to combine multiple modalities freely, explore the joint information accurately and examine the relationship between brain patterns and clinical measures smartly, such as symptom scores etc. Another aim of this proposal is to study the trait versus state effect of SZ and BP, using longitudinal data and in a 3-way fMRI-DTI-sMRI fusion. We will access data from patients who were scanned immediately after discharge and again 5-7 weeks later. This time period is when clinicians have the most difficulties in distinguishing SZ from BP. Such a valuable dataset along with the use of a cutting-edge joint analysis model, will enable us to investigate multiple group-discriminating factors and the traits which may serve as potential biomarkers of SZ or BP. In addition, the modalities (and their combinations) will be ranked according to their ability to distinguish groups, resulting in a modal selection preference. We will further evaluate whether there are natural clusters in multimodal data that provide evidence compatible the clinical diagnoses and attempt to classify patients at the level of individual psychiatric patients based on the selected group-discriminative features and novel classification algorithms. We believe the group-differentiating information retrieved from 3 modalities will enhance the sensitivity and specificity of the classification and permit more reliable and valid biomarkers to be identified by fusing similar data types from other sites. The successful completion of this project will provide a powerful tool for N-way multimodal data fusion, help characterize the traits of SZ and BP which may serve as potential biomarkers and expedite their differential diagnosis in acute settings, leading to more appropriate treatment and improved outcomes for both patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103472-07
Application #
8708150
Study Section
Special Emphasis Panel (ZGM1-TWD-Y)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
7
Fiscal Year
2014
Total Cost
$183,906
Indirect Cost
$76,043
Name
The Mind Research Network
Department
Type
DUNS #
098640696
City
Albuquerque
State
NM
Country
United States
Zip Code
87106
Bernard, Jessica A; Leopold, Daniel R; Calhoun, Vince D et al. (2015) Regional cerebellar volume and cognitive function from adolescence to late middle age. Hum Brain Mapp 36:1102-20
Yen, Tony; Khafaja, Mohamad; Lam, Nicholas et al. (2015) Post-electroconvulsive therapy recovery and reorientation time with methohexital and ketamine: a randomized, longitudinal, crossover design trial. J ECT 31:20-5
Josef Golubic, Sanja; Aine, Cheryl J; Stephen, Julia M et al. (2014) Modulatory role of the prefrontal generator within the auditory M50 network. Neuroimage 92:120-31
Coffman, Brian A; Clark, Vincent P; Parasuraman, Raja (2014) Battery powered thought: enhancement of attention, learning, and memory in healthy adults using transcranial direct current stimulation. Neuroimage 85 Pt 3:895-908
Walton, Esther; Liu, Jingyu; Hass, Johanna et al. (2014) MB-COMT promoter DNA methylation is associated with working-memory processing in schizophrenia patients and healthy controls. Epigenetics 9:1101-7
Abbott, Christopher C; Gallegos, Patrick; Rediske, Nathan et al. (2014) A review of longitudinal electroconvulsive therapy: neuroimaging investigations. J Geriatr Psychiatry Neurol 27:33-46
Arbabshirani, Mohammad R; Damaraju, Eswar; Phlypo, Ronald et al. (2014) Impact of autocorrelation on functional connectivity. Neuroimage 102 Pt 2:294-308
Chen, Jiayu; Liu, Jingyu; Calhoun, Vince D et al. (2014) Exploration of scanning effects in multi-site structural MRI studies. J Neurosci Methods 230:37-50
Hjelm, R Devon; Calhoun, Vince D; Salakhutdinov, Ruslan et al. (2014) Restricted Boltzmann machines for neuroimaging: an application in identifying intrinsic networks. Neuroimage 96:245-60
Ford, Judith M; Morris, Sarah E; Hoffman, Ralph E et al. (2014) Studying hallucinations within the NIMH RDoC framework. Schizophr Bull 40 Suppl 4:S295-304

Showing the most recent 10 out of 21 publications