This renewal of PRAABRE represents a step forward in our efforts to foster the continued development of the biomedical research infrastructure in Puerto Rico. Such continued development is achieved through the implementation of a strengthened and cohesive structure with improved integration of common scientific and educational interests, collaborations, and a newly created Mentoring Initiative. The structure of PRAABRE is represented in the following components: Administrative, Bioinformatics, Scientific Network, Centralized Research and Instrumentation, and Science and Technology and Education. The Administrative Core provides the programmatic direction for the entire PRAABRE. The new Mentoring Initiative will standardize mentoring practices among participating Institutions at all levels of intervention, from undergraduate student research to mentored research at the faculty level. This initiative will also coordinate Grantsmanship Workshops offered by Kentucky INBRE personnel on a yearly basis. The Administrative Core, via a close interaction with the External Advisory Committee and an External Independent Evaluator, will also organize the overall formative and additive evaluation process of PRAABRE. The Bioinformatics Core will assertively foster and stimulate the development of bioinformatics research, collaborations, and consulting services. This core will also be responsible for maintaining high performance lnternet-2 network capabilities at participating Institutions. Our initiative for providing Access to Biomedical Research Electronic Information will also be coordinated by the Bioinformatics Core. The Scientific Network will host 11 INBRE sponsored research projects in PRAABRE, all organized into thrust areas within the biomedical sciences. The Centralized Research and Instrumentation Core integrates the corresponding facilities established at the UPR-Rio Piedras and Medical Sciences Campuses by prior BRIN and INBRE cycles, as well as by COBRE and RCMI, all NCRR programs. The Science and Technology Competene and Education Core will host the PRAABRE Seminar Series, Technology Transfer Awards, Faculty Summer Internships, Continued Education and Technology Competence Workshops, and the Science-on-Wheels project, a K-12 initiative. This PRAABRE Core will also help coordinate Summer Internships in Kentucky for PRAABRE students, an Initiative covered by the Kentucky INBRE. A special quality of this renewal application is the collaborations among the distinct cores, which makes the proposed efforts a true networking of ideas, education, and biomedical research in the Island of Puerto Rico.

Public Health Relevance

This renewal application will further augment and strengthen Puerto Rico's biomedical research capacity, productivity, and competitiveness. PRAABRE will continue to build upon the established biomedical research network of 16 Institutions with a scientific focus on Neuroscience, Molecular Medicine, and Drug Design. PRAABRE will also serve as a pipeline for students throughout the development of their scientific careers and contribute to the development of a knowledge-based economy in the Island.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
8P20GM103475-12
Application #
8294973
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Program Officer
Canto, Maria Teresa
Project Start
2001-09-15
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
12
Fiscal Year
2012
Total Cost
$3,511,672
Indirect Cost
$537,453
Name
University of Puerto Rico Rio Piedras
Department
Type
DUNS #
090051616
City
San Juan
State
PR
Country
United States
Zip Code
00926
Silva-Torres, L A; Vélez, C; Lyvia Alvarez, J et al. (2014) Toxic effects of xylazine on endothelial cells in combination with cocaine and 6-monoacetylmorphine. Toxicol In Vitro 28:1312-9
Andreoli, Mirko; Persico, Marco; Kumar, Ajay et al. (2014) Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells. J Med Chem 57:7916-32
Nadeau, Nicola J; Ruiz, Mayté; Salazar, Patricio et al. (2014) Population genomics of parallel hybrid zones in the mimetic butterflies, H. melpomene and H. erato. Genome Res 24:1316-33
Sanabria-Rios, David J; Rivera-Torres, Yaritza; Maldonado-Dominguez, Gamalier et al. (2014) Antibacterial activity of 2-alkynoic fatty acids against multidrug-resistant bacteria. Chem Phys Lipids 178:84-91
Ramos-Pratts, Keyla; Rosa-Gonzalez, Dariana; Perez-Acevedo, Nivia L et al. (2013) Sex-specific effect of the anabolic steroid, 17*-methyltestosterone, on inhibitory avoidance learning in periadolescent rats. Behav Processes 99:73-80
Orengo-Mercado, Carmelo; Nieves, Bianca; Lopez, Lizbeth et al. (2013) Frequencies of Functional Polymorphisms in Three Pharmacokinetic Genes of Clinical Interest within the Admixed Puerto Rican Population. J Pharmacogenomics Pharmacoproteomics 4:
Zha, Xueqiang; Diaz, Ricardo; Franco, Jose Javier Rosado et al. (2013) Inhibitors of urokinase type plasminogen activator and cytostatic activity from crude plants extracts. Molecules 18:8945-58
Fasoli, Ezio; Reyes, Yiaslin Ruiz; Guzman, Osiris Martinez et al. (2013) Para-aminobenzamidine linked regenerated cellulose membranes for plasminogen activator purification: effect of spacer arm length and ligand density. J Chromatogr B Analyt Technol Biomed Life Sci 930:13-21