Core A will continue to provide scientific, fiscal, administrative, and logistic oversight to all aspects of the Center. As before. Core personnel will facilitate communication among investigators and the sharing of reagents, tools, specimens, and data to ensure appropriate allocation and effective use of Center funds. The Core will also continue to: provide clerical support;coordinate interactions between facility cores and research projects;organize regular investigator meetings and;provide biostatistical support. In addition to these functions, the Core will develop and implement a clear path for transition to and attainment of independent status and for the continued career development of early career investigators . The Core will provide leadership and administrative support needed to maintain the thematic focus of the Center and to achieve Center goal. It will provide mentorshp to early-career investigaotrs by expanding curernt mentoring activitis, while continued to provide personalized mentoring. Core personnel will encourage the exploratoin of new research avenues and phase out unpromising resarch and maximize the intellectual environment of the Center. The Core will also provide statistical support to assist in study design and analysis and help in developing grant proposals. It will monitor evaluate overall Center progress in achieving specific milestones. Core personel will prepare annual scientific reports and financial statements and plan and organize symposia, seminars and regulary-scheduled meetings. They will invite prominent scientists to present seminars and interact with Center members and communiate with University and NIH officials to report progress and discuss Center related issues. In consultation with the external and internal advisory committee, the Program Director will recruit new faculty to replace graduating COBRE investigators and if required increase the critical mass of investiagtors working in the Center. If required, Core A will adopt remedial measures for Principal Investigators who fail to satisfactory review by the External Advisory Committee. The Core will also maintain a Center Website and faciliate the dissemination of information about Center activities as well as diabetes and obesity.

Public Health Relevance

The Core will provide administrative support to the Diabetes and Obesity Center at the University of Louisville and therefore contribute to the development of new and effective strategies for prevention and treatment of diabetes and obesity research by facilitating research in this area and by providing mentoring and training to the next generation of scientists.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103492-07
Application #
8711505
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
7
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Louisville
Department
Type
DUNS #
City
Louisville
State
KY
Country
United States
Zip Code
40202
Hosen, Mohammed Rabiul; Militello, Giuseppe; Weirick, Tyler et al. (2018) Airn Regulates Igf2bp2 Translation in Cardiomyocytes. Circ Res 122:1347-1353
Dassanayaka, Sujith; Zheng, Yuting; Gibb, Andrew A et al. (2018) Cardiac-specific overexpression of aldehyde dehydrogenase 2 exacerbates cardiac remodeling in response to pressure overload. Redox Biol 17:440-449
Dwenger, Marc M; Ohanyan, Vahagn; Navedo, Manuel F et al. (2018) Coronary microvascular Kv1 channels as regulatory sensors of intracellular pyridine nucleotide redox potential. Microcirculation 25:
Jin, Lexiao; Lipinski, Alexandra; Conklin, Daniel J (2018) A Simple Method for Normalization of Aortic Contractility. J Vasc Res 55:177-186
Lindsey, Merry L; Bolli, Roberto; Canty Jr, John M et al. (2018) Guidelines for experimental models of myocardial ischemia and infarction. Am J Physiol Heart Circ Physiol 314:H812-H838
Uchida, Shizuka; Jones, Steven P (2018) RNA Editing: Unexplored Opportunities in the Cardiovascular System. Circ Res 122:399-401
Liang, Yaqin; Lang, Anna L; Zhang, Jian et al. (2018) Exposure to Vinyl Chloride and Its Influence on Western Diet-Induced Cardiac Remodeling. Chem Res Toxicol 31:482-493
Trainor, Patrick J; Yampolskiy, Roman V; DeFilippis, Andrew P (2018) Wisdom of artificial crowds feature selection in untargeted metabolomics: An application to the development of a blood-based diagnostic test for thrombotic myocardial infarction. J Biomed Inform 81:53-60
Zafar, Nagma; Krishnasamy, Sathya S; Shah, Jasmit et al. (2018) Circulating angiogenic stem cells in type 2 diabetes are associated with glycemic control and endothelial dysfunction. PLoS One 13:e0205851
Hoetker, David; Chung, Weiliang; Zhang, Deqing et al. (2018) Exercise alters and ?-alanine combined with exercise augments histidyl dipeptide levels and scavenges lipid peroxidation products in human skeletal muscle. J Appl Physiol (1985) :

Showing the most recent 10 out of 110 publications