The primary goal of this COBRE renewal will remain the development of a critical mass of independently funded investigators who study the genetic and immunologic mechanisms that promote chronic inflammation, to understand its role in disease and, ultimately, to improve patient outcome. The success of the first cycle of this COBRE is represented by the retention, as faculty members, of 8 of the 9 promising junior investigators (PJIs) who started the program. Seven of them are independently funded. Mentors and PJIs generated a combined 148 peer reviewed publications of which 41% were authored or co-authored by the PJIs. The newly selected 8 PJIs have the unique opportunity to study a large local population of minority individuals, who represent approximately 50% of the patients seen at LSU Health Sciences Center (LSUHSC). This population suffers disproportionately from cancer, chronic infections, cardiovascular disease and other diseases considered to have a chronic inflammatory component. As in the initial cycle, most of our new PJIs are minority faculty, who are generally underrepresented in the pool of federally funded researchers. To optimize their future development and their competitiveness we have leveraged the scientific and clinical expertise at the principal academic medical centers in south Louisiana;LSUHSC, Tulane Medical Center and Ochsner Clinic Foundation. The unifying hypothesis is that chronic inflammation is the result of a dysfunctional immune response to an offending agent, causing tissue damage instead of protecting the host. Understanding the mechanisms that subvert the immune response in disease can provide insight into novel prevention and therapeutic approaches to these conditions. This concept will be studied in 5 principal projects that will determine the molecular link between inflammation and cancer (Projects 1, 2 and 3) and will evaluate the role of inflammation in chronic infections (Project 4 and 5). A limited number of early stage projects will also be supported to ensure access to a pipeline of junior investigators. The PJIs are mentored by a team of experienced and well funded senior scientists, and supported by several scientific cores. In addition, a Faculty Development Core will ensure their career advancement. The PJIs will be members of the proposed Center for Research in Chronic Inflammation and Disease (CRICD).

Public Health Relevance

Chronic inflammation is the basis for multiple disease including cancer, chronic infection and cardiovascular disease. Understanding the mechanisms that change a protective immune response into chronic inflammation that damages the hosts tissues is essential to develop new forms of prevention and treatment. We will train 8 promising junior investigators who will study chronic inflammation in diseases that disproportionately affect minority patients in Louisiana.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103501-10
Application #
8705546
Study Section
Special Emphasis Panel (ZRR1)
Program Officer
Gorospe, Rafael
Project Start
2005-09-30
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Louisiana State Univ Hsc New Orleans
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Garay, Jone; Piazuelo, M Blanca; Majumdar, Sumana et al. (2016) The homing receptor CD44 is involved in the progression of precancerous gastric lesions in patients infected with Helicobacter pylori and in development of mucous metaplasia in mice. Cancer Lett 371:90-8
Dai, Lu; Bai, Lihua; Lin, Zhen et al. (2016) Transcriptomic analysis of KSHV-infected primary oral fibroblasts: The role of interferon-induced genes in the latency of oncogenic virus. Oncotarget 7:47052-47060
Cruz-Rodriguez, Nataly; Combita, Alba L; Enciso, Leonardo J et al. (2016) High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-acute lymphoblastic leukemia. J Exp Clin Cancer Res 35:64
Maxi, John K; Dean, Matt; Zabaleta, Jovanny et al. (2016) Chronic Binge Alcohol Administration Dysregulates Hippocampal Genes Involved in Immunity and Neurogenesis in Simian Immunodeficiency Virus-Infected Macaques. Biomolecules 6:
Serrano-Gomez, Silvia Juliana; Sanabria-Salas, Maria Carolina; Hernández-Suarez, Gustavo et al. (2016) High prevalence of luminal B breast cancer intrinsic subtype in Colombian women. Carcinogenesis 37:669-76
Singleton, B; Turner, J; Walter, L et al. (2016) Environmental stress in the Gulf of Mexico and its potential impact on public health. Environ Res 146:108-15
Kadri, Ferdous; LaPlante, Andrea; De Luca, Mariacristina et al. (2016) Defining Plasma MicroRNAs Associated With Cognitive Impairment In HIV-Infected Patients. J Cell Physiol 231:829-36
Sanchez, Maria Dulfary; Ochoa, Augusto C; Foster, Timothy P (2016) Development and evaluation of a host-targeted antiviral that abrogates herpes simplex virus replication through modulation of arginine-associated metabolic pathways. Antiviral Res 132:13-25
Joseph, Ann Mary; Srivastava, Ratika; Zabaleta, Jovanny et al. (2016) Cross-talk between 4-1BB and TLR1-TLR2 Signaling in CD8+ T Cells Regulates TLR2's Costimulatory Effects. Cancer Immunol Res 4:708-16
Loupe, Jacob M; Miller, Patrick J; Bonner, Benjamin P et al. (2016) Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects. Oncotarget :

Showing the most recent 10 out of 75 publications