Abstract

The Physiologic Core (C) will be located in the Division of Animal Laboratory Resources within dedicated space at the University of Kentucky. This core will provide equipment, services and training for quantifying cardiovascular, diabetes, and obesity phenotypes. This includes measurement of atherosclerosis, quantifying sera lipoprotein cholesterol, ultrasound for assessing vascular and cardiac function, MRI for analyzing cardiac function and fat deposifion, and tail cuff and radiotelemetry platforms to quantify blood pressure. For diabetes, this includes training and service in performing glucose and insulin tolerance tests in mice, and for small scale studies using euglycemic hyperinsulinemic clamps in mice. For obesity, this includes echoMRI to quantify fat/lean mass, TSE LabMaster chambers to quantify food/water intake, physical activity and indirect calorimetry, and PhenoMaster chambers for urine/feces collection.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM103527-06
Application #
8602566
Study Section
Special Emphasis Panel (ZGM1-TWD-Y (C2))
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
6
Fiscal Year
2013
Total Cost
$188,072
Indirect Cost
$62,690

  Institution

Name
University of Kentucky
Department
Type
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506

  Publications

Jama, Abdulrahman; Huang, Dengtong; Alshudukhi, Abdullah A et al. (2018) Lipin1 is required for skeletal muscle development by regulating MEF2c and MyoD expression. J Physiol :
Federico, Lorenzo; Yang, Liping; Brandon, Jason et al. (2018) Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice. PLoS One 13:e0198063
Shridas, Preetha; De Beer, Maria C; Webb, Nancy R (2018) High-density lipoprotein inhibits serum amyloid A-mediated reactive oxygen species generation and NLRP3 inflammasome activation. J Biol Chem 293:13257-13269
Wilson, Patricia G; Thompson, Joel C; Shridas, Preetha et al. (2018) Serum Amyloid A Is an Exchangeable Apolipoprotein. Arterioscler Thromb Vasc Biol 38:1890-1900
Petriello, Michael C; Brandon, J Anthony; Hoffman, Jessie et al. (2018) Dioxin-like PCB 126 Increases Systemic Inflammation and Accelerates Atherosclerosis in Lean LDL Receptor-Deficient Mice. Toxicol Sci 162:548-558
Alsiraj, Yasir; Thatcher, Sean E; Blalock, Eric et al. (2018) Sex Chromosome Complement Defines Diffuse Versus Focal Angiotensin II-Induced Aortic Pathology. Arterioscler Thromb Vasc Biol 38:143-153
Thompson, Joel C; Wilson, Patricia G; Wyllie, Alex P et al. (2018) Elevated circulating TGF-? is not the cause of increased atherosclerosis development in biglycan deficient mice. Atherosclerosis 268:68-75
Thalman, Carine; Horta, Guilherme; Qiao, Lianyong et al. (2018) Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders. Mol Psychiatry 23:1699-1710
Lee, Scott J; Zea, Ryan; Kim, David H et al. (2018) CT texture features of liver parenchyma for predicting development of metastatic disease and overall survival in patients with colorectal cancer. Eur Radiol 28:1520-1528
Brandon, Jason A; Farmer, Brandon C; Williams, Holden C et al. (2018) APOE and Alzheimer's Disease: Neuroimaging of Metabolic and Cerebrovascular Dysfunction. Front Aging Neurosci 10:180

Showing the most recent 10 out of 235 publications