The Physiologic Core (C) will be located in the Division of Animal Laboratory Resources within dedicated space at the University of Kentucky. This core will provide equipment, services and training for quantifying cardiovascular, diabetes, and obesity phenotypes. This includes measurement of atherosclerosis, quantifying sera lipoprotein cholesterol, ultrasound for assessing vascular and cardiac function, MRI for analyzing cardiac function and fat deposifion, and tail cuff and radiotelemetry platforms to quantify blood pressure. For diabetes, this includes training and service in performing glucose and insulin tolerance tests in mice, and for small scale studies using euglycemic hyperinsulinemic clamps in mice. For obesity, this includes echoMRI to quantify fat/lean mass, TSE LabMaster chambers to quantify food/water intake, physical activity and indirect calorimetry, and PhenoMaster chambers for urine/feces collection.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103527-07
Application #
8733721
Study Section
Special Emphasis Panel (ZGM1-TWD-Y)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
7
Fiscal Year
2014
Total Cost
$188,122
Indirect Cost
$62,740
Name
University of Kentucky
Department
Type
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Crack, Peter J; Zhang, Moses; Morganti-Kossmann, Maria Cristina et al. (2014) Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes. J Neuroinflammation 11:37
Liu, Xiaoxi; Liu, Jingjing; Liang, Shuang et al. (2014) ABCD2 alters peroxisome proliferator-activated receptor ? signaling in vitro, but does not impair responses to fenofibrate therapy in a mouse model of diet-induced obesity. Mol Pharmacol 86:505-13
Su, Kai; Sabeva, Nadezhda S; Wang, Yuhuan et al. (2014) Acceleration of biliary cholesterol secretion restores glycemic control and alleviates hypertriglyceridemia in obese db/db mice. Arterioscler Thromb Vasc Biol 34:26-33
Wang, Fengbin; Singh, Shanteri; Zhang, Jianjun et al. (2014) Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from SulfolobusĀ solfataricus. FEBS J 281:4224-39
Shaaban, Khaled A; Singh, Shanteri; Elshahawi, Sherif I et al. (2014) Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2. J Antibiot (Tokyo) 67:223-30
Newsome, Bradley J; Petriello, Michael C; Han, Sung Gu et al. (2014) Green tea diet decreases PCB 126-induced oxidative stress in mice by up-regulating antioxidant enzymes. J Nutr Biochem 25:126-35
Zhang, Jianjun; Singh, Shanteri; Hughes, Ryan R et al. (2014) A simple strategy for glycosyltransferase-catalyzed aminosugar nucleotide synthesis. Chembiochem 15:647-52
Liu, M; Alimov, A P; Wang, H et al. (2014) Thiamine deficiency induces anorexia by inhibiting hypothalamic AMPK. Neuroscience 267:102-13
Jiang, Erlie; Perrard, Xiaoyuan Dai; Yang, Donglin et al. (2014) Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue. Arterioscler Thromb Vasc Biol 34:34-43
Shridas, Preetha; Zahoor, Lubna; Forrest, Kathy J et al. (2014) Group X secretory phospholipase A2 regulates insulin secretion through a cyclooxygenase-2-dependent mechanism. J Biol Chem 289:27410-7

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