Nearly two-thirds of the US population is either clinically overweight or obese and almost 10% of the population has adult-onset diabetes. Obesity and diabetes are central elements of a cluster of pathologies collectively referred to as "metabolic syndrome". Our Center of Biomedical Research Excellence (COBRE) at the Pennington Biomedical Research Center is leading an effort to enhance research on metabolic disease by recruiting accomplished senior investigators and promising young scientists who are mentored to independence by Center investigators. The Pennington COBRE involves five projects from outstanding junior faculty that employ a combination of cellular, molecular, and translational approaches to address questions ranging from neural mechanisms of glucose sensing and energy homeostasis, inflammatory mechanisms linked to adipogenesis, epigenetic programming in obesity, to regulation of mitochondrial biogenesis in adipocytes. Using a combination of in vivo, ex vivo and in vitro approaches, each project will pursue fundamental questions critical to regulation of energy homeostasis and the associated pathologies of metabolic disease linked to expansion of adipose tissue mass during development of obesity.
The Specific Aims of our COBRE in Phase II are to further expand the critical mass of productive investigators engaged in obesity/diabetes research by (a) develop and retain outstanding new junior faculty from within the institution and mentor them to sustainable independent funding (b) recruit outstanding junior and senior faculty engaged in metabolic disease research that complement existing strengths of Center investigators;(c) develop and foster new opportunities for collaborative interactions with institutional colleagues engaged in clinical/translational research, (d) enhance utilization of the outstanding research infrastructure developed within the Cell Biology/Bioimaging and Genomics core facilities in Phase I through development of training modules and outreach activities. Our Phase II COBRE goals are to recruit 5 new faculty to the institution and mentor 10 junior faculty to independent funding as we continue to build a critical mass of scientists devoted to finding solutions to the expanding national health problem of metabolic disease.

Public Health Relevance

Obesity and diabetes affect a large and growing segment of the population but Louisiana is disproportionately affected because of the higher incidence of metabolic disease in our state. The COBRE at Pennington is devoted to discovering cellular mechanisms of metabolic disease and translating these discoveries into more effective treatments that will lessen the burden of chronic disease and improve the quality of life.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Taylor, Fred
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Lsu Pennington Biomedical Research Center
Organized Research Units
Baton Rouge
United States
Zip Code
Orgeron, Manda L; Stone, Kirsten P; Wanders, Desiree et al. (2014) The impact of dietary methionine restriction on biomarkers of metabolic health. Prog Mol Biol Transl Sci 121:351-76
Ruggiero, Christine; Elks, Carrie M; Kruger, Claudia et al. (2014) Albumin-bound fatty acids but not albumin itself alter redox balance in tubular epithelial cells and induce a peroxide-mediated redox-sensitive apoptosis. Am J Physiol Renal Physiol 306:F896-906
Soni, Mufaddal S; Rabaglia, Mary E; Bhatnagar, Sushant et al. (2014) Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion. Diabetes 63:3805-14
Ghosh, Sujoy; Wanders, Desiree; Stone, Kirsten P et al. (2014) A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary methionine restriction in rats. FASEB J 28:2577-90
Stone, Kirsten P; Wanders, Desiree; Orgeron, Manda et al. (2014) Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice. Diabetes 63:3721-33
Wanders, Desiree; Ghosh, Sujoy; Stone, Kirsten P et al. (2014) Transcriptional impact of dietary methionine restriction on systemic inflammation: relevance to biomarkers of metabolic disease during aging. Biofactors 40:13-26
Kappen, Claudia; Salbaum, J Michael (2014) Gene expression in teratogenic exposures: a new approach to understanding individual risk. Reprod Toxicol 45:94-104
Tchoukalova, Y D; Krishnapuram, R; White, U A et al. (2014) Fetal baboon sex-specific outcomes in adipocyte differentiation at 0.9 gestation in response to moderate maternal nutrient reduction. Int J Obes (Lond) 38:224-30
Tam, Charmaine S; Covington, Jeffrey D; Bajpeyi, Sudip et al. (2014) Weight gain reveals dramatic increases in skeletal muscle extracellular matrix remodeling. J Clin Endocrinol Metab 99:1749-57
Bajpeyi, Sudip; Myrland, Cassandra K; Covington, Jeffrey D et al. (2014) Lipid in skeletal muscle myotubes is associated to the donors' insulin sensitivity and physical activity phenotypes. Obesity (Silver Spring) 22:426-34

Showing the most recent 10 out of 26 publications