The specific aims for the COBRE for Perinatal Biology are to continue our scientific contributions to the field of perinatal biology and to further development of the research enterprise at Women &Infants Hospital. The common theme of this proposal is that mechanisms for regulation of development during the fetal or early postnatal period can inform importantly the regulatory mechanisms governing cell function, organ maturation, health and disease in later life. This theme is highlighted in the projects will support: 1) host pathogen interactions, developmental immunology and the molecular pathogenesis of yeast infections of Candida albicans in the preterm infant;2) DMA methylation and chromatin remodeling as a biomolecular "fingerprint" in the placenta for adverse intrauterine life and fetal programming;3) the role of hypoxia and hypoxia-regulated genes in early embryogenesis and implantation;4) recapitulation of the "fetal gene program" during stem cell repair of cardiac injury in adult life;5) the immunopathogenesis of preeclampsia;6) role of natural killer cells in successful pregnancy outcomes. The programmatic aims of this COBRE are to continue to provide scientific and career mentorship to Junior Faculty in an interdisciplinary environment that fosters creativity and transdisciplinary collaboration in scientific approaches. Using resources from our prior period of support we have developed a robust perinatal research center in the Kilguss Research Institute which has become a state-of-the-art research facility. It houses the majority of this group of young scientists, all of whom have demonstrated excellent potential for independent careers, as well as successful, senior investigators. This award will allow us to continue to leverage our programs and the environment we have created into the kinds of support needed by all young investigators to become successful independent investigators. The award will allow them to collaborate with leading scientists in their fields and to utilize contemporary approaches in cell and molecular biology to address important issues in perinatal and developmental biology. The combination of a supportive environment within a robust setting of inquiry and exploration will allow us to enhance/ensure their career trajectories as independent investigators. The clinical relevance of these areas is borne out by their high likelihood to identify important mechanisms during development which inform the pathogenesis of disease across the life spectrum. This program is based at the Women &Infants Hospital of Rhode Island. It will provide support for four full projects and 2 pilot projects of Junior Faculty who will me mentored by established investigators from . An outstanding group of investigators from other centers will provide support and collaboration as the External Scientific Advisory Committee.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
8P20GM103537-10
Application #
8322127
Study Section
Special Emphasis Panel (ZRR1-RI-6 (01))
Program Officer
Canto, Maria Teresa
Project Start
2003-09-30
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2014-07-31
Support Year
10
Fiscal Year
2012
Total Cost
$2,104,517
Indirect Cost
$568,596
Name
Women and Infants Hospital-Rhode Island
Department
Type
DUNS #
069851913
City
Providence
State
RI
Country
United States
Zip Code
02905
Wu, Zhiping; Horgan, Casie E; Carr, Olivia et al. (2014) Biglycan and decorin differentially regulate signaling in the fetal membranes. Matrix Biol 35:266-75
Sadowska, G B; Stonestreet, B S (2014) Maternal treatment with glucocorticoids modulates gap junction protein expression in the ovine fetal brain. Neuroscience 275:248-58
Horgan, Casie E; Roumimper, Hailey; Tucker, Richard et al. (2014) Altered decorin and Smad expression in human fetal membranes in PPROM. Biol Reprod 91:105
Kobashigawa, Laura C; Xu, Yan Chun; Padbury, James F et al. (2014) Metformin protects cardiomyocyte from doxorubicin induced cytotoxicity through an AMP-activated protein kinase dependent signaling pathway: an in vitro study. PLoS One 9:e104888
Zhang, Peng; Mende, Ulrike (2014) Functional role, mechanisms of regulation, and therapeutic potential of regulator of G protein signaling 2 in the heart. Trends Cardiovasc Med 24:85-93
Triche, Elizabeth W; Uzun, Alper; DeWan, Andrew T et al. (2014) Bioinformatic approach to the genetics of preeclampsia. Obstet Gynecol 123:1155-61
Lesseur, Corina; Armstrong, David A; Paquette, Alison G et al. (2013) Tissue-specific Leptin promoter DNA methylation is associated with maternal and infant perinatal factors. Mol Cell Endocrinol 381:160-7
Mao, Quanfu; Chu, Sharon; Ghanta, Sailaja et al. (2013) Ex vivo expanded human cord blood-derived hematopoietic progenitor cells induce lung growth and alveolarization in injured newborn lungs. Respir Res 14:37
De Paepe, Monique E; Mao, Quanfu; Chu, Sharon et al. (2013) Long-term outcome of human cord blood-derived hematopoietic progenitor cells in murine lungs. Exp Lung Res 39:59-69
Ouyang, Qing; Lizarraga, Sofia B; Schmidt, Michael et al. (2013) Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development. Neuron 80:97-112

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