The link between chronic oral infections and general health has been recognized since the early 20th century. During the last 2 decades, retrospective epidemiological studies and prospective longitudinal, as well as intervention, studies have supported that these chronic oral infections with accompanying chronic inflammation associate with various systemic diseases and their sequelae. This continuation application for the Center for the Biologic Basis of Oral/System Diseases (CBBO/SD) addresses major initiatives of the National Institute of Dental and Craniofacial Research (NIDCR) regarding improving oral and general health ofthe U.S. population. The CBBO/SD is organized into 3 cInical projects: Project 1: Chronic Inflammation at the Oral and Cervico/Vaginal Mucosa;Project 2: Physiology of the Stress Response in Patients with Temporomandibular Disorders and Fibromyalgia;Project 3: Coordinated Oral-Intestinal Immune Response in Patients with Inflammatory Bowel Diseases;and 2 translational science projects: Project 4: Ontogeny of Innate Immune Responses at Mucosal Surfaces;and Project 5: Gene Therapy for Orofacial Pain. These projects enlist junior investigators from the Colleges of Dentistry, Nursing, and Medicine, as well as senior mentors/co-investigators from multiple colleges at UK. The thematic interface of the projects focuses on the contribution of chronic inflammation to oral and systemic diseases. They engage populations of expectant women, patients with chronic orofacial pain, and inflammatory bowel disease. These clinical projects interact with the translational projects at the level of a common understanding of innate immune responses and inflammation, and novel therapeutic intervention strategies forthe chronic orofacial pain. The CBBO/SD provides an infrastructure for development of the junior faculty by providing grants management support, educational opportunities, a biostatistics/bioinformatics core, and a clinical research center. The continuation of the CBBO/SD is supported by the success during the initial tenure of the center in transitioning junior investigators towards independent funding, coupled with substantial investment from the university and individual colleges.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Liu, Yanping
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Kentucky
Schools of Dentistry
United States
Zip Code
Ebersole, Jeffrey L; Kirakodu, Sreenatha; Novak, Michael John et al. (2014) Cytokine gene expression profiles during initiation, progression and resolution of periodontitis. J Clin Periodontol 41:853-61
Miller, Craig S; Westgate, Philip M (2014) Implications of medical screenings of patients arriving for dental treatment: the results of a comprehensive laboratory screening. J Am Dent Assoc 145:1027-35
Ebersole, J L; Steffen, M J; Thomas, M V et al. (2014) Smoking-related cotinine levels and host responses in chronic periodontitis. J Periodontal Res 49:642-51
Gonzalez, Octavio A; Novak, Michael J; Kirakodu, Sreenatha et al. (2014) Comparative analysis of gingival tissue antigen presentation pathways in ageing and periodontitis. J Clin Periodontol 41:327-39
Syndergaard, Ben; Al-Sabbagh, Mohanad; Kryscio, Richard J et al. (2014) Salivary biomarkers associated with gingivitis and response to therapy. J Periodontol 85:e295-303
Gonzalez, Octavio A; Novak, M John; Kirakodu, Sreenatha et al. (2013) Effects of aging on apoptosis gene expression in oral mucosal tissues. Apoptosis 18:249-59