The link between chronic oral infections and general health has been recognized since the early 20th century. During the last 2 decades, retrospective epidemiological studies and prospective longitudinal, as well as intervention, studies have supported that these chronic oral infections with accompanying chronic inflammation associate with various systemic diseases and their sequelae. This continuation application for the Center for the Biologic Basis of Oral/System Diseases (CBBO/SD) addresses major initiatives of the National Institute of Dental and Craniofacial Research (NIDCR) regarding improving oral and general health ofthe U.S. population. The CBBO/SD is organized into 3 cInical projects: Project 1: Chronic Inflammation at the Oral and Cervico/Vaginal Mucosa;Project 2: Physiology of the Stress Response in Patients with Temporomandibular Disorders and Fibromyalgia;Project 3: Coordinated Oral-Intestinal Immune Response in Patients with Inflammatory Bowel Diseases;and 2 translational science projects: Project 4: Ontogeny of Innate Immune Responses at Mucosal Surfaces;and Project 5: Gene Therapy for Orofacial Pain. These projects enlist junior investigators from the Colleges of Dentistry, Nursing, and Medicine, as well as senior mentors/co-investigators from multiple colleges at UK. The thematic interface of the projects focuses on the contribution of chronic inflammation to oral and systemic diseases. They engage populations of expectant women, patients with chronic orofacial pain, and inflammatory bowel disease. These clinical projects interact with the translational projects at the level of a common understanding of innate immune responses and inflammation, and novel therapeutic intervention strategies forthe chronic orofacial pain. The CBBO/SD provides an infrastructure for development of the junior faculty by providing grants management support, educational opportunities, a biostatistics/bioinformatics core, and a clinical research center. The continuation of the CBBO/SD is supported by the success during the initial tenure of the center in transitioning junior investigators towards independent funding, coupled with substantial investment from the university and individual colleges.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Liu, Yanping
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Kentucky
Schools of Dentistry
United States
Zip Code
Gonzalez, O A; Nagarajan, R; Novak, M J et al. (2016) Immune system transcriptome in gingival tissues of young nonhuman primates. J Periodontal Res 51:152-63
Ebersole, Jeffrey L; Kirakodu, Sreenatha S; Novak, M John et al. (2016) Transcriptome Analysis of B Cell Immune Functions in Periodontitis: Mucosal Tissue Responses to the Oral Microbiome in Aging. Front Immunol 7:272
Ebersole, J L; Kryscio, R J; Campbell, C et al. (2016) Salivary and serum adiponectin and C-reactive protein levels in acute myocardial infarction related to body mass index and oral health. J Periodontal Res :
Huang, Chifu B; Alimova, Yelena; Ebersole, Jeffrey L (2016) Macrophage polarization in response to oral commensals and pathogens. Pathog Dis 74:
Nagarajan, R; Miller, C S; Dawson 3rd, D et al. (2016) Cross-talk between clinical and host-response parameters of periodontitis in smokers. J Periodontal Res :
Nagarajan, Radhakrishnan; Al-Sabbagh, Mohanad; Dawson 3rd, Dolph et al. (2016) Integrated Biomarker Profiling of Smokers with Periodontitis. J Clin Periodontol :
Gonzalez, Octavio A; Orraca, Luis; Kensler, Terry B et al. (2016) Familial periodontal disease in the Cayo Santiago rhesus macaques. Am J Primatol 78:143-51
Pandruvada, Subramanya N; Gonzalez, Octavio A; Kirakodu, Sreenatha et al. (2016) Bone biology-related gingival transcriptome in ageing and periodontitis in non-human primates. J Clin Periodontol 43:408-17
Johnson, N; Ebersole, J L; Kryscio, R J et al. (2016) Rapid assessment of salivary MMP-8 and periodontal disease using lateral flow immunoassay. Oral Dis 22:681-7
Ebersole, J L; Kirakodu, S; Novak, M J et al. (2016) Effects of aging in the expression of NOD-like receptors and inflammasome-related genes in oral mucosa. Mol Oral Microbiol 31:18-32

Showing the most recent 10 out of 27 publications