Significant biomedical therapies are likely to result from novel biomaterials that are designed at the molecular level to offer customized control over their mechanical and biological properties. The realization of such biomaterials requires the formation of productive research relationships between the diverse communities of organic chemistry, molecular design, biology, biophysical chemistry, and materials engineering. Furthermore, the ultimate clinical implementation of new biomaterials will require consistent interactions between research scientists and the medical practitioners who can eventually translate fundamental research into the clinic. The proposed COBRE renewal application """"""""Molecular Design of Responsive Biomaterials"""""""" will focus on the design of biomaterials for regeneration of liver and vocal fold tissues, and for drug-lead identification and payload delivery. A common design principle is that the macroscopic properties of these materials can be controlled in large part by the conformational properties and biological specificity of the constituent molecular building blocks, and that new chemical strategies and characterization methods will be integral to their design. Materials will be developed by evaluating of the interplay between material structure and morphology, mechanical properties, biochemical interactions, in vitro cell-material interactions, and in vivo tissue responses. These studies will ultimately generate materials systems that are optimized for their intended applications. The organization of the proposed center capitalizes on the scientific successes of our current COBRE individual subprojects, which have developed expertise and state-of-the-art core facilities for chemical, biochemical, and materials methodologies applicable to a broad spectrum of biomaterials. In addition to these scientific aims, the proposed center activities will also enhance faculty development and infrastructure development through the integration of the research team, expansion of active mentoring programs at the University of Delaware (UD), additions to the instrumentation core, establishment of new seed areas, and strategic new hires. Our research team brings together junior and early-career scientists from the UD Departments of Chemistry and Biochemistry, Materials Science and Engineering, and Chemical Engineering who will be mentored by internationally known experts in their fields. The team will also collaborate with senior investigators from UD and with clinicians from the state of Delaware's flagship research hospitals? Christiana Care and A.I. duPont Hospital for Children, which will integrate biomaterials research in the state of Delaware. These efforts, coupled with new hires and projects, will establish a dynamic environment for interdisciplinary biomedical research that will increase the research competitiveness of the investigators and the team and will bring new science and potential technology to the biomaterials community.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
8P20GM103541-10
Application #
8322694
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Canto, Maria Teresa
Project Start
2002-09-16
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2014-07-31
Support Year
10
Fiscal Year
2012
Total Cost
$2,066,285
Indirect Cost
$756,294
Name
University of Delaware
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716
Cobb, Kelsey M; Rabb-Lynch, Javon M; Hoerrner, Megan E et al. (2017) Stereospecific, Nickel-Catalyzed Suzuki-Miyaura Cross-Coupling of Allylic Pivalates To Deliver Quaternary Stereocenters. Org Lett 19:4355-4358
Liang, Yingkai; Li, Linqing; Scott, Rebecca A et al. (2017) Polymeric Biomaterials: Diverse Functions Enabled by Advances in Macromolecular Chemistry. Macromolecules 50:483-502
Greco, Chad T; Andrechak, Jason C; Epps 3rd, Thomas H et al. (2017) Anionic Polymer and Quantum Dot Excipients to Facilitate siRNA Release and Self-Reporting of Disassembly in Stimuli-Responsive Nanocarrier Formulations. Biomacromolecules 18:1814-1824
Greco, Chad T; Muir, Victoria G; Epps 3rd, Thomas H et al. (2017) Efficient tuning of siRNA dose response by combining mixed polymer nanocarriers with simple kinetic modeling. Acta Biomater 50:407-416
Basch, Corey H; Liao, Jennie; Xu, Jianyu et al. (2017) Harnessing Alkyl Amines as Electrophiles for Nickel-Catalyzed Cross Couplings via C-N Bond Activation. J Am Chem Soc 139:5313-5316
Kharkar, Prathamesh M; Scott, Rebecca A; Olney, Laura P et al. (2017) Controlling the Release of Small, Bioactive Proteins via Dual Mechanisms with Therapeutic Potential. Adv Healthc Mater 6:
Basch, Corey H; Cobb, Kelsey M; Watson, Mary P (2016) Nickel-Catalyzed Borylation of Benzylic Ammonium Salts: Stereospecific Synthesis of Enantioenriched Benzylic Boronates. Org Lett 18:136-9
Freudenberg, Uwe; Liang, Yingkai; Kiick, Kristi L et al. (2016) Glycosaminoglycan-Based Biohybrid Hydrogels: A Sweet and Smart Choice for Multifunctional Biomaterials. Adv Mater 28:8861-8891
Panish, Robert A; Chintala, Srinivasa R; Fox, Joseph M (2016) A Mixed-Ligand Chiral Rhodium(II) Catalyst Enables the Enantioselective Total Synthesis of Piperarborenine?B. Angew Chem Int Ed Engl 55:4983-7
Zhou, Qi; Srinivas, Harathi D; Zhang, Songnan et al. (2016) Accessing Both Retention and Inversion Pathways in Stereospecific, Nickel-Catalyzed Miyaura Borylations of Allylic Pivalates. J Am Chem Soc 138:11989-11995

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