The Center for Biomolecular Structure and Dynamics (CBSD) at the University of Montana (UM) is rooted in structural biology but multidisciplinary in scope. The rationale that underlies this program is based on the perception that effective biomedical innovation is driven from an understanding of macromolecular structure, which in turn, must be grounded on principles of experimental and theoretical chemistry. CBSD faculty are drawn from Department of Chemistry &Biochemistry, the Division of Biological Science and the Department of Biomedical and Pharmaceutical Sciences. Among this group are CBSD faculty with expertise in spectroscopy, structural biology, biochemistry and mechanistic and theoretical chemistry. We build on a strong foundation of sustained institutional support. Associated with the CBSD is a newly established interdisciplinary graduate program in Biochemistry and Biophysics. The goal of the proposed COBRE is to integrate investigators with research interests in cell and molecular physiology, mechanistic biochemistry, chemical biology, and theoretical and computational chemistry, into an interactive and collaborative network. With the creation of a CBSD COBRE, it is our goal to give structure to this vision by implementing the four aims of this proposal:
Aim 1. Provide research support for five interdisciplinary research projects within the COBRE theme. These projects use theoretical and physical chemical methods to elucidate the catalytic mechanisms of enzymes involved in signal transduction and tryptophan catabolism. Structure-based homology modeling and chemical biology approaches will be used to design new ligands for the opioid receptor and to characterize the binding sites of the multidrug resistance transporter. Heteronuclear NMR experiments will be used to elucidate the structures of critical domains in the Junin arenavirus membrane fusion glycoprotein.
Aim 2 shall be to recruit two new faculty members to CBSD-affiliated departments to build on existing strengths and introduce new expertise within the CBSD.
Aim 3 will support collaborative activities involving CBSD faculty by sustaining of critical core research facilities in Macromolecular X-ray diffraction, Macromolecular NMR, BioSpectroscopy and Molecular Computation.
Aim 4 will establish a supportive program to sustain an intellectually vibrant and cohesive CBSD that promotes infrastructure development, mentoring, scientific exchange and collaboration, with a robust advisory and self-assessment structure.

Public Health Relevance

A Center of excellence in Biomolecular Structure and dynamics will be established to conduct research to understand the biophysical basis of human disease. Current projects focus on transport of chemotherapeutic compounds, molecules that control psychiatric disorders, enzymes involved in cellular signal transduction and in amino acid metabolism and viral proteins that mediate infection.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
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Special Emphasis Panel (ZRR1-RI-3 (01))
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Caldwell, Sheila
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University of Montana
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Yi, Feng; DeCan, Evan; Stoll, Kurt et al. (2015) Muscarinic excitation of parvalbumin-positive interneurons contributes to the severity of pilocarpine-induced seizures. Epilepsia 56:297-309
Khatri, Alpa; Burger, Pieter B; Swanger, Sharon A et al. (2014) Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator. Mol Pharmacol 86:548-60
Lacher, Sarah E; Gremaud, Julia N; Skagen, Kasse et al. (2014) Absence of P-glycoprotein transport in the pharmacokinetics and toxicity of the herbicide paraquat. J Pharmacol Exp Ther 348:336-45
Stierle, Andrea A; Stierle, Donald B (2014) Bioactive secondary metabolites from acid mine waste extremophiles. Nat Prod Commun 9:1037-44
Sprang, Stephen R (2013) An acid test for g proteins. Mol Cell 51:405-6
Drecktrah, Dan; Hall, Laura S; Hoon-Hanks, Laura L et al. (2013) An inverted repeat in the ospC operator is required for induction in Borrelia burgdorferi. PLoS One 8:e68799
Sharmin, Ayesha; Salassa, Luca; Rosenberg, Edward et al. (2013) Photophysical studies of bioconjugated ruthenium metal-ligand complexes incorporated in phospholipid membrane bilayers. Inorg Chem 52:10835-45
Wang, Hui; Rascoe, Avi M; Holley, David C et al. (2013) Novel dicarboxylate selectivity in an insect glutamate transporter homolog. PLoS One 8:e70947
Zhou, Momei; Yu, Qin; Wechsler, Anya et al. (2013) Comparative analysis of gO isoforms reveals that strains of human cytomegalovirus differ in the ratio of gH/gL/gO and gH/gL/UL128-131 in the virion envelope. J Virol 87:9680-90
Matti, Afnan A; Mirzaei, Joseph; Rudolph, John et al. (2013) Microwave accelerated synthesis of isoxazole hydrazide inhibitors of the system xc- transporter: Initial homology model. Bioorg Med Chem Lett 23:5931-5

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