This is a proposal to establish a Center of Biomedical Research Excellence (COBRE) focusing on Cancer Biology with emphasis on the identification, functional characterization, and targeting of tumor specific markers and antigens. Our center will use cell and molecular biology, immunology, nanoparticle technology, and animal models to examine the development, detection, and treatment of human cancer. Five research projects are included. The goals of Project 1 (Meena Jaggi, PhD) are to understand the effects of protein kinase Dl on (3- catenin-mediated signaling and to determine if PKD1 expression influences tumor progression through this pathway. For Project 2 (Kristi Egland, PhD) a large number of membrane and secreted proteins that are expressed at elevated levels in prostate cancer cells were identified. This information will be used to develop a new diagnostic test for prostate cancer that detects autoantibodies in patient serum. Project 3 (Satoshi Nagata, PhD) will develop a panel of monoclonal antibodies to surface antigens that are highly expressed in B cell malignancies. These antibodies will be tested for their potential use in immunotherapies. Project 4 (Subhash Chauhan, PhD) will develop novel methods of treatment and drug delivery for pancreatic cancer. The goal will be to combine radioimmunotherapy and nanoparticle technology for highly specific delivery of cytotoxic compounds. Project 5 (William Spanos, MD) will focus on the role of the immune response in tumor clearance following treatment of head and neck squamous cell carcinoma. A strong mentoring plan will take advantage of the experience of an outstanding group of senior faculty with active research programs. Mentors will provide guidance for research design, manuscript preparation, grant applications, and other crucial aspects of career development. An EAC consisting of five internationally recognized scientists with broad experience in basic, translational, and clinical research has been assembled. Research capabilities will be supported by core facilities in Molecular Pathology, Flow Cytometry, Tumor Biology, and Imaging. We will recruit 3 high quality junior investigators and 1 established investigator. We will train students and post-doctoral fellows, support a seminar series, and fund pilot research projects in the field of cancer research.

Public Health Relevance

There is currently no comprehensive cancer center in the state of South Dakota that encompasses clinical, basic and translational cancer research. With this COBRE there will be a sizable increase in the number of scientists in South Dakota engaged in cancer research. The result of COBRE funding will be a substantially improved and modernized research infrastructure, forming the foundation for cancer research in this region.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
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Special Emphasis Panel (ZRR1-RI-B (01))
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Caldwell, Sheila
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Sanford Research/Usd
Sioux Falls
United States
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Dykstra, Jordan A; Facile, Tiffany; Patrick, Ryan J et al. (2017) Concise Review: Fat and Furious: Harnessing the Full Potential of Adipose-Derived Stromal Vascular Fraction. Stem Cells Transl Med 6:1096-1108
Forred, Benjamin J; Daugaard, Darwin R; Titus, Brianna K et al. (2017) Detoxification of Mitochondrial Oxidants and Apoptotic Signaling Are Facilitated by Thioredoxin-2 and Peroxiredoxin-3 during Hyperoxic Injury. PLoS One 12:e0168777
Grassmeyer, Justin; Mukherjee, Malini; deRiso, Jennifer et al. (2017) Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression. Dev Biol 424:77-89
Yao, Qingqing; Cosme, Jaqueline G L; Xu, Tao et al. (2017) Three dimensional electrospun PCL/PLA blend nanofibrous scaffolds with significantly improved stem cells osteogenic differentiation and cranial bone formation. Biomaterials 115:115-127
Grausam, Katie B; Dooyema, Samuel D R; Bihannic, Laure et al. (2017) ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas. Cancer Res 77:3766-3777
Otterpohl, Karla L; Hart, Ryan G; Evans, Claire et al. (2017) Nonmuscle myosin 2 proteins encoded by Myh9, Myh10, and Myh14 are uniquely distributed in the tubular segments of murine kidney. Physiol Rep 5:
Beraldi, Rosanna; Meyerholz, David K; Savinov, Alexei et al. (2017) Genetic ataxia telangiectasia porcine model phenocopies the multisystemic features of the human disease. Biochim Biophys Acta 1863:2862-2870
Messerli, Shanta M; Hoffman, Mariah M; Gnimpieba, Etienne Z et al. (2017) 4SC-202 as a Potential Treatment for the Pediatric Brain Tumor Medulloblastoma. Brain Sci 7:
Birendra Kc; May, Danielle G; Benson, Benjamin V et al. (2017) VRK2A is an A-type lamin-dependent nuclear envelope kinase that phosphorylates BAF. Mol Biol Cell 28:2241-2250
Yao, Qingqing; Sandhurst, Eric S; Liu, Yangxi et al. (2017) BBP-Functionalized Biomimetic Nanofibrous Scaffold Can Capture BMP2 and Promote Osteogenic Differentiation. J Mater Chem B 5:5196-5205

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